Inactivation of viruses using nonthermal plasma in viral suspensions and foodstuff: A short review of recent studies

Mohammadi, Masoud Aman; Ahangari, Hossein; Khajavi, Maryam Zabihzadeh; Yousefi, Mohammad; Scholtz, Vladimír; Hosseini, Seyede Marzieh

doi:10.1111/jfs.12919

Cited by 8 publications

(4 citation statements)

References 70 publications

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“…Surface contagion can pose a high risk of transmission as the infectious virions can stay viable on various surfaces (e.g., plastic, metals, and cardboard) for several hours [ 2 , 3 ]. Several traditional sterilization processes (sodium hypochlorite, soap water, steam, dry heat, alcohol, and UV) used for the surface decontamination have numerous shortcomings, and inventive methods are required for the virus inactivation [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Virucidal Efficacy of Cold Plasma on Bacteriophage Inside a Three-Layered Sterilization Chamber

Nagar

Kar

Pansare-Godambe

et al. 2022

Plasma Chem Plasma Process

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Traditional disinfection methods against pathogens have numerous shortcomings, and inventive methods like cold plasma are required for virus inactivation. Here, an atmospheric pressure 13.56 MHz radio-frequency hollow cathode (RF–HC) cold plasma device has been used to build a cold plasma sterilization device, and its virucidal activity is assessed against P2 bacteriophage, a model surrogate for pathogenic viruses. The heart of this device contains a three-layered sterilization chamber which is a rectangular parallelopiped of 42 × 32 × 30 cm 3 . Optimization experiments were performed to make each corner of this chamber completely virus free after cold plasma treatment. This two-pronged study was conducted to establish the requirement of minimum vol. % H 2 O 2 in minimum time for the complete elimination of phages inside this sterilization chamber even when plasma is not in the direct line of sight. In initial experiments, the effect of the direct plasma line of sight was seen as the top and bottom layers showing less phage killing as compared to the middle of the sterilization chamber. Complete sterilization of bacteriophage, in all the three layers inside the sterilization chamber, was achieved by plasma treatment with 6% H 2 O 2 for 10 min in 80 watts of plasma operating power. It was also seen that 6% H 2 O 2 mist alone is not sufficient to provide a high degree of sterilization, and normal water mist combined with cold plasma can provide a higher level of sterilization at each corner of the chamber.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Virucidal Efficacy of Cold Plasma on Bacteriophage Inside a Three-Layered Sterilization Chamber

Nagar

Kar

Pansare-Godambe

et al. 2022

Plasma Chem Plasma Process

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“…Many experiments have shown that plasmas can effectively kill viruses or reduce their infectivity [10,11]. In 1999, Kelly-Wintenberg and colleagues published the first paper relating to the inactivation of viral microorganisms by plasma [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…With the rapid development of plasma technology, plasma has proved to be effective in killing bacteriophages, human adenovirus, HIV and many other viral microorganisms [12][13][14][15]. In the current global COVID-19 pandemic, the application of plasma to reduce the infectivity of SARS-CoV-2 and control the outbreak has become a hot topic.…”

Section: Introductionmentioning

confidence: 99%

Reactive force field-based molecular dynamics simulation of the interaction between plasma reactive oxygen species and the receptor-binding domain of the spike protein in the capsid protein of SARS-CoV-2

Wang

Zhao

Zou

et al. 2021

J. Phys. D: Appl. Phys.

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Under the pressures of the current global pandemic, researchers have been working hard to find a reliable way to suppress infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and prevent the spread of COVID-19. Studies have shown that the recognition and binding of human angiotensin-converting enzyme 2 by the receptor-binding domain (RBD) of the spike protein on the surface of SARS-CoV-2 is a crucial step in viral invasion of human receptor cells, and blocking this process could inhibit the virus from invading normal human cells. Plasma treatment can disrupt the structure of the RBD and effectively block the binding process. However, the mechanism by which plasma blocks recognition and binding is not clear. In this study, the reaction between reactive oxygen species (ROS) in plasma and a molecular model of the RBD was simulated using a reactive molecular dynamics method. The results showed that the destruction of the RBD by ROS was triggered by hydrogen abstraction reactions: O and OH abstracted H atoms from the RBD, while the H atoms of H2O2 and HO2 were abstracted by the RBD. This hydrogen abstraction resulted in the breakage of C–H, N–H, O–H and C=O bonds and the formation of C=C and C=N bonds. The addition reaction of OH increased the number of O–H bonds and caused the formation of C–O, N–O and O–H bonds. The dissociation of N–H bonds led to the destruction of the original peptide bond structure and amino acid residues, changed the type of amino acid residues and caused the conversion of N–C and N=C and C=O and C–O. The simulation partially elucidated the microscopic mechanism of the interaction between ROS in plasma and the capsid protein of SARS-CoV-2, providing theoretical support for the control of SARS-CoV-2 infection by plasma, a contribution to overcoming the global pandemic.

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“…The disinfection effects of NTP have been studied mainly on bacteria, but attempts to inactivate viruses [39][40][41] or fungi both in vitro and in vivo [42,43] were also made. In general, the sensitivity of various microbes to NTP differs substantially: while the inactivation of bacteria is complete within seconds to minutes, yeasts require exposure for several minutes and mold and bacterial spores several tens of minutes.…”

Section: Introductionmentioning

confidence: 99%

Inactivation of Acanthamoeba Cysts in Suspension and on Contaminated Contact Lenses Using Non-Thermal Plasma

et al. 2021

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Water suspensions of cysts of a pathogenic clinical isolate of Acanthamoeba sp. were prepared, and the cysts were inactivated either in suspension or placed on the surface of contact lenses by the non-thermal plasma produced by the DC corona transient spark discharge. The efficacy of this treatment was determined by cultivation and the presence of vegetative trophozoites indicating non-inactivated cysts. The negative discharge appeared to be more effective than the positive one. The complete inactivation occurred in water suspension after 40 min and on contaminated lenses after 50 min of plasma exposure. The properties of lenses seem to not be affected by plasma exposure; that is, their optical power, diameter, curvature, water content and infrared and Raman spectra remain unchanged.

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Inactivation of viruses using nonthermal plasma in viral suspensions and foodstuff: A short review of recent studies

Cited by 8 publications

References 70 publications

Evaluation of Virucidal Efficacy of Cold Plasma on Bacteriophage Inside a Three-Layered Sterilization Chamber

Evaluation of Virucidal Efficacy of Cold Plasma on Bacteriophage Inside a Three-Layered Sterilization Chamber

Reactive force field-based molecular dynamics simulation of the interaction between plasma reactive oxygen species and the receptor-binding domain of the spike protein in the capsid protein of SARS-CoV-2

Inactivation of Acanthamoeba Cysts in Suspension and on Contaminated Contact Lenses Using Non-Thermal Plasma

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