Inactivation of the Nucl. Accumbens Core Exerts No Effect on Nicotine-Induced Conditioned Place Preference

Hosseini, Shirin; Sahraei, Hedayat; Mohammadi, Alireza; Hatef, Boshra; Meftahi, Gholam Hossein; Chalabi-Yani, Durna; Ali-Beig, Hengameh; Sadeghi-Gharajehdaghi, Sara; Ranjabaran, M.

doi:10.1007/s11062-015-9536-8

Cited by 9 publications

(10 citation statements)

References 32 publications

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“…Psychological stress occurs when a person perceives that environmental demands exceed his or her adaptive capacity . Animal studies have revealed that stress may cause pathological damage in the hippocampus, which is involved in learning and memory . Each person reacts differently to stressful situations.…”

Section: Introductionmentioning

confidence: 99%

Low resilience to stress is associated with candidate gene expression alterations in the dopaminergic signalling pathway

2018

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Section: Introductionmentioning

confidence: 99%

Low resilience to stress is associated with candidate gene expression alterations in the dopaminergic signalling pathway

2018

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“…Moreover, cognitive ability such as judgment can be affected by environmental factors (6). Also, drug abuse as a stress factor could damage the central nervous system (7, 8). Various environmental factors can stimulate the synthesis and secretion of cortisol due to the activity of the hypothalamus-pituitary-adrenal (HPA) axis.…”

Section: Introductionmentioning

confidence: 99%

The Effect of 20 Minutes Scuba Diving on Cognitive Function of Professional Scuba Divers

et al. 2016

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BackgroundPhysical activity increases the performance of the nervous system by stimulating the body’s metabolism and improving the efficiency of the ATP production system.ObjectivesIn the present study, the effect of twenty minutes scuba diving in high depth (10m) on cognitive function and stress system activity was investigated.MethodsTwelve professional scuba divers with a mean age of 23 ± 1 year, weight of 80 ± 2.5 kg and height of 1.79 ± 3.5 cm resident in the city of Mashhad participated in the test. Their cognitive functions were measured 60 min before and 20 min after diving and the data were evaluated using the PASAT software. In the present study, parameters such as general mental health, sustained attention, average response speed, and mental fatigue were measured. Moreover, in order to determine the activity of the stress system, their salivary cortisol was collected before and after diving.ResultsResults revealed that, the general mental health of these scuba divers was normal and it did not undergo a remarkable change after diving. Their average response speed and sustained attention had a significant decrease after scuba diving. Mental fatigue after diving increased. Also, salivary cortisol level significantly increased after diving.ConclusionsAccording to our data, it seems that scuba diving as stress stimulant increases cortisol level and therefore reduces cognitive performance after diving.

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“…Place conditioning was conducted using an unbiased procedure. The conditioned place preference consisted of three phases: pre‐conditioning, conditioning and post conditioning …”

Section: Methodsmentioning

confidence: 99%

Effects of unilatral‐ and bilateral inhibition of rostral ventral tegmental area and central nucleus of amygdala on morphine‐induced place conditioning in male Wistar rat

Mohammadian

Sahraei

Meftahi

et al. 2017

Clin Exp Pharma Physio

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Summary The rostral ventral tegmental area (VTAR) and central nucleus of amygdala (CeA) are considered the main regions for induction of psychological dependence on abused drugs, such as morphine. The main aim of this study was to investigate the transient inhibition of each right and left side as well as both sides of the VTAR and the CeA by lidocaine (2%) on morphine reward properties using the conditioned place preference (CPP) method. Male Wistar rats (250±20 g) 7 days after recovery from surgery and cannulation were conditioned to morphine (7.5 mg/kg) in CPP apparatus. Five minutes before morphine injection in conditioning phase, lidocaine was administered either uni‐ or bilaterally into the VTAR (0.25 μL/site) or CeA (0.5 μL/site). The results revealed that lidocaine administration into the left side, but not the right side of the VTAR and the CeA reduced morphine CPP significantly. The reduction was potentiated when lidocaine was injected into both sides of the VTAR and the CeA. The number of compartment crossings was reduced when lidocaine was injected into both sides of the VTAR and the CeA as well as the left side. Rearing was reduced when lidocaine was injected into the right, but not the left side of the VTAR. Sniffing and rearing increased when animals received lidocaine in the right side and reduced in the group that received lidocaine in the left side of the CeA. It was concluded that the right and the left side of VTAR and the CeA play different roles in morphine‐induced activity and reward.

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Inactivation of the Nucl. Accumbens Core Exerts No Effect on Nicotine-Induced Conditioned Place Preference

Cited by 9 publications

References 32 publications

Low resilience to stress is associated with candidate gene expression alterations in the dopaminergic signalling pathway

Low resilience to stress is associated with candidate gene expression alterations in the dopaminergic signalling pathway

The Effect of 20 Minutes Scuba Diving on Cognitive Function of Professional Scuba Divers

Effects of unilatral‐ and bilateral inhibition of rostral ventral tegmental area and central nucleus of amygdala on morphine‐induced place conditioning in male Wistar rat

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