Inactivation of SARS-CoV-2 on surfaces and in solution with Virusend (TX-10), a novel disinfectant

Anderson, Enyia R; Hughes, Grant L; Patterson, Edward I

doi:10.1101/2020.11.25.394288

Cited by 5 publications

(9 citation statements)

References 21 publications

(26 reference statements)

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“…Amongst all the reviewed and included studies, 28 articles were categorised in disinfection methods with potential activity on environmental surfaces [ 12 , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] ]. A summary of this category is provided in table II .…”

Section: Resultsmentioning

confidence: 99%

“…Surface disinfectants based on citric acid, hydrochloride acid or lactic acid were also shown to efficiently reduce viral titres of coronaviruses (including SARS-CoV-2) [ 12 ]. Virusend (TX-10), a detergent-based disinfectant, was able to reduce by at least 4.0log10 PFU/mL of infectious SARS-CoV-2 with high titre inoculum and a reduction of at least 2.3log10 PFU/mL with low titre inoculum on both hard surfaces, such as stainless steel, and in solution [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…Interestingly, viral load deposited in freshly collected human saliva demonstrated a log10 reduction trend more similar to PBS compared to DMEM-A. Bovine serum albumin (BSA) containing higher concentrations of protein can be utilised to mimic body fluids, particularly sputum [ 31 , 42 ]. This may suggest that laboratory-made solutions may not fully represent the behaviour of biological fluids.…”

Section: Discussionmentioning

confidence: 99%

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Disinfection methods against SARS-CoV-2: a systematic review

Martins

Xavier

Cobrado

2022

Journal of Hospital Infection

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Background The novel SARS-CoV-2, responsible for the most recent pandemic faced by humanity, has become a global crisis causing millions of deaths. The virus is transmitted by inhalation of infectious particles suspended in the air, direct deposition on mucous membranes and indirect contact via contaminated surfaces. Therefore, disinfection methods that can halt such transmission are important in this pandemic and in future viral infections. Aim Highlight the efficacy of several disinfection methods against SARS-CoV-2, based on up-to-date evidence found in literature. Methods A research was conducted through two databases to assess the disinfection methods used against SARS-CoV-2. From a total of 1229 studies found, 60 were included. Quality assessment was evaluated by the OHAT risk of bias tool. Findings Disinfection methods on environmental surfaces were approached by 28 studies; 16 articles addressed disinfection methods used on biological surfaces; 4 articles presented disinfection methods for airborne coronavirus and 16 studies demonstrated methods used to recondition PPEs. Conclusions Several household and hospital disinfection agents and UV-C irradiation were effective in inactivating SARS-CoV-2 on environmental surfaces. Formulations containing povidone-iodine can provide virucidal action on the skin and mucous membranes. In the case of hand hygiene, typical soap bars and alcohols can inactivate SARS-CoV-2. Air filtration systems incorporated with materials that possess catalytic properties, UV-C devices and heating systems can effectively reduce airborne viral particles. The decontamination of PPEs can be conducted safely by heat and ozone treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Disinfection methods against SARS-CoV-2: a systematic review

Martins

Xavier

Cobrado

2022

Journal of Hospital Infection

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“…Virusend (TX-10) application was found to inactivate SARS-CoV-2 in an in vitro study based on surface and solution inactivation assays. This novel disinfectant rapidly decreased the SARS-CoV-2 viral titer by 4log 10 PFU/mL within a contact period of 1 min (Anderson et al 2020).…”

Section: Updated Disinfection Approaches Against Sars-cov-2mentioning

confidence: 92%

The role of disinfectants and sanitizers during COVID-19 pandemic: advantages and deleterious effects on humans and the environment

Dhama

Patel

Kumar

et al. 2021

Environ Sci Pollut Res

124

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Disinfectants and sanitizers are essential preventive agents against the coronavirus disease 2019 (COVID-19) pandemic; however, the pandemic crisis was marred by undue hype, which led to the indiscriminate use of disinfectants and sanitizers. Despite demonstrating a beneficial role in the control and prevention of COVID-19, there are crucial concerns regarding the large-scale use of disinfectants and sanitizers, including the side effects on human and animal health along with harmful impacts exerted on the environment and ecological balance. This article discusses the roles of disinfectants and sanitizers in the control and prevention of the current pandemic and highlights updated disinfection techniques against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This article provides evidence of the deleterious effects of disinfectants and sanitizers exerted on humans, animals, and the environment as well as suggests mitigation strategies to reduce these effects. Additionally, potential technologies and approaches for the reduction of these effects and the development of safe, affordable, and effective disinfectants are discussed, particularly, eco-friendly technologies using nanotechnology and nanomedicine.

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“…All experiments were carried out in triplicates. SARS-CoV-2 titre was calculated using standard plaque assays as previously described [33]. Briefly, samples were serially diluted in DMEM containing 2 % FBS and incubated with Vero cells for 1 h. After incubation, an overlay with DMEM 2 % FBS, 0.1 % gentamycin and 0.4 % agarose was applied to the cells.…”

Section: Virus Inactivation By Different Mouthwash Formulationsmentioning

confidence: 99%

CPC-containing oral rinses inactivate SARS-CoV-2 variants and are active in the presence of human saliva

Anderson

Patterson

Richards

et al. 2022

Journal of Medical Microbiology

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Introduction. The importance of human saliva in aerosol-based transmission of SARS-CoV-2 is now widely recognized. However, little is known about the efficacy of virucidal mouthwash formulations against emergent SARS-CoV-2 variants of concern and in the presence of saliva. Hypothesis. Mouthwashes containing virucidal actives will have similar inactivation effects against multiple SARS-CoV-2 variants of concern and will retain efficacy in the presence of human saliva. Aim. To examine in vitro efficacy of mouthwash formulations to inactivate SARS-CoV-2 variants. Methodology. Inactivation of SARS-CoV-2 variants by mouthwash formulations in the presence or absence of human saliva was assayed using ASTM International Standard E1052-20 methodology. Results. Appropriately formulated mouthwashes containing 0.07 % cetylpyridinium chloride but not 0.2 % chlorhexidine completely inactivated SARS-CoV-2 (USA-WA1/2020, Alpha, Beta, Gamma, Delta) up to the limit of detection in suspension assays. Tests using USA-WA1/2020 indicates that efficacy is maintained in the presence of human saliva. Conclusions. Together these data suggest cetylpyridinium chloride-based mouthwashes are effective at inactivating SARS-CoV-2 variants. This indicates potential to reduce viral load in the oral cavity and mitigate transmission via salivary aerosols.

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Inactivation of SARS-CoV-2 on surfaces and in solution with Virusend (TX-10), a novel disinfectant

Cited by 5 publications

References 21 publications

Disinfection methods against SARS-CoV-2: a systematic review

Disinfection methods against SARS-CoV-2: a systematic review

The role of disinfectants and sanitizers during COVID-19 pandemic: advantages and deleterious effects on humans and the environment

CPC-containing oral rinses inactivate SARS-CoV-2 variants and are active in the presence of human saliva

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