Inactivation of Protein Farnesyltransferase by Active-Site-Targeted Dicarbonyl Compounds

Magnesium Oxide

“…Its poor solubility in both aqueous and organic medium, however, requires heterogeneous reaction conditions. Magnesium oxide is a common reagent used for selective N-acylation of amino acids and amino alcohols to provide the corresponding amides, 14 sulfonamides, 15 and carbamates. 16 Surprisingly, the only O-acylation gleaned from the literature uses phenol in the presence of MgO to form a phosphate ester.…”