Inactivation of bacterial quorum sensing signals N-acyl homoserine lactones is widespread in yeasts

Leguina, Ana Carolina del Valle; Nieto, Carolina; Pajot, Hipólito F.; Bertini, Elisa Violeta; Cormack, Walter P. Mac; Figueroa, Lucía I. C. de; Nieto-Peñalver, Carlos Gabriel

doi:10.1016/j.funbio.2017.10.006

Cited by 13 publications

(8 citation statements)

References 39 publications

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“…However, it is unlikely that the modification in the 6N2 QS regulation can be attributed to a fungal inactivation of QS signals. Even though QQ is prevalent in yeasts, M. guilliermondii 6N exhibits only a weak capacity for inactivating AHLs [10]. Probably other mechanisms take part in the M. guilliermondii 6N-A.…”

Section: Discussionmentioning

confidence: 99%

“…During a previous survey of the endophytic microbiota of sugarcane (Saccharum officinarum L.), we isolated the yeast Meyerozyma guilliermondii strain 6N and A. tumefaciens strain 6N2 from the same node section, suggesting that these two microorganisms can co-occupy this niche and, in consequence, interact with each other [11,12]. In contrast to other species, this M. guilliermondii isolate show a very weak capacity to inactivate AHLs [10].…”

Section: Introductionmentioning

confidence: 90%

“…It is expectable that these unicellular fungi interact with bacteria, including agrobacteria, in the endophytic polymicrobial communities. Their role in QS mediated interactions is unknown, even if a capacity to inactivate AHLs was demonstrated in several species [10].…”

Section: Introductionmentioning

confidence: 99%

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Insight in the quorum sensing-driven lifestyle of the non-pathogenic Agrobacterium tumefaciens 6N2 and the interactions with the yeast Meyerozyma guilliermondii

Bertini

Torres

Léger

et al. 2021

Preprint

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Agrobacterium tumefaciens is considered a prominent phytopathogen, though most isolates are nonpathogenic. Agrobacteria can inhabit plant tissues interacting with other microorganisms. Yeasts are likewise part of these communities. We analyzed the quorum sensing (QS) systems of A. tumefaciens strain 6N2, and its relevance for the interaction with the yeast Meyerozyma guilliermondii, both sugarcane endophytes. We show that strain 6N2 is nonpathogenic, produces OHC8-HSL, OHC10-HSL, OC12-HSL and OHC12-HSL as QS signals, and possesses a complex QS architecture, with one truncated, two complete systems, and three additional QS-signal receptors. A proteomic approach showed differences in QS-regulated proteins between pure (64 proteins) and dual (33 proteins) cultures. Seven proteins were consistently regulated by quorum sensing in pure and dual cultures. M. guilliermondii proteins influenced by QS activity were also evaluated. Several up- and down- regulated proteins differed depending on the bacterial QS. These results show the importance of the QS regulation in the bacteria-yeast interactions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

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Insight in the quorum sensing-driven lifestyle of the non-pathogenic Agrobacterium tumefaciens 6N2 and the interactions with the yeast Meyerozyma guilliermondii

Bertini

Torres

Léger

et al. 2021

Preprint

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“…Furthermore, it has recently been found that S. cerevisiae responds to typical bacterial quorum sensing molecules by modulating ethanol tolerance and cell morphology [68]. Conversely, several yeast species can inactivate bacterial quorum sensing signals [69]. This opens the possibility for not only quorum sensing, but also quorum quenching, playing a role in microbial interactions in winemaking.…”

Section: Contact-independentmentioning

confidence: 99%

Mechanisms Involved in Interspecific Communication between Wine Yeasts

Mencher

Morales

Tronchoni

et al. 2021

Foods

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In parallel with the development of non-Saccharomyces starter cultures in oenology, a growing interest has developed around the interactions between the microorganisms involved in the transformation of grape must into wine. Nowadays, it is widely accepted that the outcome of a fermentation process involving two or more inoculated yeast species will be different from the weighted average of the corresponding individual cultures. Interspecific interactions between wine yeasts take place on several levels, including interference competition, exploitation competition, exchange of metabolic intermediates, and others. Some interactions could be a simple consequence of each yeast running its own metabolic programme in a context where metabolic intermediates and end products from other yeasts are present. However, there are clear indications, in some cases, of specific recognition between interacting yeasts. In this article we discuss the mechanisms that may be involved in the communication between wine yeasts during alcoholic fermentation.

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“…Many organisms, including bacteria [70,71,72,73,74], yeasts [75,76,77], fungi [78,79], and marine and terrestrial plants [80,81,82,83] and animals [84,85,86] have developed the ability to disrupt AHL-based QS systems through various mechanisms (reviews: [54,55,87,88]). The first mechanism described is based on the production of molecules that act as antagonists of signals and interfere with the detection of signal molecules by their cognate transcriptional regulator (Figure 2).…”

Section: Inhibition Of Quorum Sensing Mechanismsmentioning

confidence: 99%

Saline Environments as a Source of Potential Quorum Sensing Disruptors to Control Bacterial Infections: A Review

2019

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Saline environments, such as marine and hypersaline habitats, are widely distributed around the world. They include sea waters, saline lakes, solar salterns, or hypersaline soils. The bacteria that live in these habitats produce and develop unique bioactive molecules and physiological pathways to cope with the stress conditions generated by these environments. They have been described to produce compounds with properties that differ from those found in non-saline habitats. In the last decades, the ability to disrupt quorum-sensing (QS) intercellular communication systems has been identified in many marine organisms, including bacteria. The two main mechanisms of QS interference, i.e., quorum sensing inhibition (QSI) and quorum quenching (QQ), appear to be a more frequent phenomenon in marine aquatic environments than in soils. However, data concerning bacteria from hypersaline habitats is scarce. Salt-tolerant QSI compounds and QQ enzymes may be of interest to interfere with QS-regulated bacterial functions, including virulence, in sectors such as aquaculture or agriculture where salinity is a serious environmental issue. This review provides a global overview of the main works related to QS interruption in saline environments as well as the derived biotechnological applications.

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Inactivation of bacterial quorum sensing signals N-acyl homoserine lactones is widespread in yeasts

Cited by 13 publications

References 39 publications

Insight in the quorum sensing-driven lifestyle of the non-pathogenic Agrobacterium tumefaciens 6N2 and the interactions with the yeast Meyerozyma guilliermondii

Insight in the quorum sensing-driven lifestyle of the non-pathogenic Agrobacterium tumefaciens 6N2 and the interactions with the yeast Meyerozyma guilliermondii

Mechanisms Involved in Interspecific Communication between Wine Yeasts

Saline Environments as a Source of Potential Quorum Sensing Disruptors to Control Bacterial Infections: A Review

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