Inactivation of a non-enveloped RNA virus by artificial ribonucleases: Honey bees and Acute bee paralysis virus as a new experimental model for in vivo antiviral activity assessment

Antiviral Effect of Ribonuclease from <i>Bacillus pumilus</i> against Phytopathogenic Rna-Viruses

“…Bacillus cereus ZH14 is found to produce a new type of antiviral ribonuclease, which is secreted into medium and active against tobacco mosaic virus [6] [7]. Recent studies demonstrate the ability of artificial ribonucleases (a RNases, small organic RNA cleaving compounds) to inactivate Rna-viruses via the synergetic effect of viral RNA cleavage and disruption of viral envelope [8]. Taken together, these data allow us to explore the possibility of using target bacterial enzymes to inhibit plant pathogenic viruses.…”

Synthesis and structure–activity relationship of novel 1,4-diazabicyclo[2.2.2]octane derivatives as potent antimicrobial agents

“…Previous work by our group has identified a number of DABCO derivatives capable of phosphodiester bond cleavage [24] and the compounds with antiviral activity [25,26].…”

To Bee or not to Bee, this is the Question … The Inborn Numerical Competence of Humans and Honeybees

“…Honeybees, which are available almost in unlimited numbers, may in the future possibly play a role as alternative experimental animals instead of mice and rats. 15 The surprising fact that honeybees in our "delayed match-to-sample" experiments 6 recognize and remember up to three and partially fourt objects correctly even if they see three blue dots at the entrance (Fig. 2) and three yellow lemons at the correct exit A' and two blue dots at the wrong exit B' has an important consequence:…”