Inactivation and inhibition of African swine fever virus by monoolein, monolinolein, and ?-linolenyl alcohol

Sola, Ana; Rodríguez, Silvia; Gancedo, A. García; Vilas, Pilar; Gil-Fernández, Carmen

doi:10.1007/bf01310882

Cited by 25 publications

(12 citation statements)

References 5 publications

(4 reference statements)

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“…These acids also play important roles in immunity since arachidonic acid is the immediate precursor of the eicosaonoids, the family of biologically active substances which includes the prostaglandins and the leukotrienes. Finally, both unsaturated and saturated fatty acids may inactivate certain viruses in vitro and inhibit their replication in vivo (23).…”

mentioning

confidence: 99%

Effect of high doses of essential fatty acids on the postviral fatigue syndrome

Behan¹,

Behan²,

Horrobin³

1990

Acta Neurologica Scandinavica

124

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Sixty-three adults with the diagnosis of the postviral fatigue syndrome were enrolled in a double-blind, placebo-controlled study of essential fatty acid therapy. The patients had been ill for from one to three years after an apparently viral infection, suffering from severe fatigue, myalgia and a variety of psychiatric symptoms. The preparation given contained linoleic, gamma-linolenic, eicosapentaenoic and docosahexaenoic acids and either it, or the placebo, was given as 8 x 500 mg capsules per day over a 3-month period. The trial was parallel in design and patients were evaluated at entry, one month and three months. In consultation with the patient the doctors assessed overall condition, fatigue, myalgia, dizziness, poor concentration and depression on a 3-point scale. The essential fatty acid composition of their red cell membrane phospholipids was analysed at the first and last visits. At 1 month, 74% of patients on active treatment and 23% of those on placebo assessed themselves as improved over the baseline, with the improvement being much greater in the former. At 3 months the corresponding figures were 85% and 17% (p less than 0.0001) since the placebo group had reverted towards the baseline state while those in the active group showed continued improvement. The essential fatty acid levels were abnormal at the baseline and corrected by active treatment. There were no adverse events. We conclude that essential fatty acids provide a rational, safe and effective treatment for patients with the post-viral fatigue syndrome.

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mentioning

confidence: 99%

Effect of high doses of essential fatty acids on the postviral fatigue syndrome

Behan¹,

Behan²,

Horrobin³

1990

Acta Neurologica Scandinavica

124

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“…Such a relation was similar to the saturated monoacyl trehalose, maltoses and sucroses [23], and the 6-O-acyl mannose and fructose [26]. 4.2 Effect of unsaturated degree of the acyl chain on CMC and γ CMC The degree of unsaturation in the acyl chain also affected the surface properties, while not as obviously as that of the chain length. The CMC was higher with higher degree of unsaturation, while the γ CMC was almost same (Fig.…”

Section: Effect Of Acyl Chain Length On Cmc and γ Cmcmentioning

confidence: 80%

“…The health and nutritional benefits of the unsaturated fatty acid esters, such as antivirus and dental care, were also observed [4,13]. Besides, it is reported that the oxidation stability of polyunsaturated fatty acid esters is much more stable than that of PUFAs themselves [14,15].…”

Section: Introductionmentioning

confidence: 96%

“…However, the high freezing point of saturated sugar esters restricts their utilization in the foods, cosmetic, and pharmaceutical fields. In recent years, unsaturated sugar esters have attracted considerable attention due to their special characteristics, such as healthy functionality, strong surface properties, and low freezing point [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Effects of fatty acid chain length and degree of unsaturation on the surface activities of monoacyl trehaloses

Sun

Xia

Tang

et al. 2009

Front. Chem. Eng. China

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The surface properties of monoacyl trehaloses with different acyl chains were investigated at 30°C, 40°C, 50°C, and 60°C. Monoacyl trehaloses were enzymatically synthesized and purified with silica gel column chromatography and semi-preparative high-performance liquid chromatography (HPLC), and the purity of products was identified by mass spectrometry (MS) and nuclear magnetic resonance (NMR). The surface tension of monoacyl trehalose in pure water was measured using Doüy ring method at different temperatures. The critical micelle concentrations (CMC), surface tension at the CMC, γ CMC , and residual area per molecule, a, were estimated from the curves. The CMC value of unsaturated monoacyl trehalose was affected by both the degree of unsaturation and the acyl chain length, and the effect of chain length on the CMC value was much stronger than that of the unsaturation degree. However, there was no significant dependency of the γ CMC value and a values on the chain length or the unsaturated degree.

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“…Conversely, unsaturated fatty acids, such as oleic acid, increase membrane fluidity and diminish the infectivity and hemolytic activity of enveloped animal virus particles. No such effects have been described for non-lipid-enveloped animal virus particles (Kohn et al, 1980;Sola et al, 1986a). Oleic acid (Fig.…”

Section: Oleic Acidmentioning

confidence: 99%

Picornavirus inhibitors

Carrasco

1994

Pharmacology & Therapeutics

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Picornaviruses are among the best understood animal viruses in molecular terms. A number of important human and animal pathogens are members of the Picornaviridae family. The genome organization, the different steps of picornavirus growth and numerous compounds that have been reported as inhibitors of picornavirus functions are reviewed. The picornavirus particles and several agents that interact with them have been solved at atomic resolution, leading to computer-assisted drug design. Picornavirus inhibitors are useful in aiding a better understanding of picornavirus biology. In addition, some of them are promising therapeutic agents. Clinical efficacy of agents that bind to picornavirus particles has already been demonstrated.

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Inactivation and inhibition of African swine fever virus by monoolein, monolinolein, and ?-linolenyl alcohol

Cited by 25 publications

References 5 publications

Effect of high doses of essential fatty acids on the postviral fatigue syndrome

Effect of high doses of essential fatty acids on the postviral fatigue syndrome

Effects of fatty acid chain length and degree of unsaturation on the surface activities of monoacyl trehaloses

Picornavirus inhibitors

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