Inactivation and Disinfection of Porcine Parvovirus on a Nonporous Surface

Lukula, Salimatu; Chiossone, Cory; Fanuel, Semhar; Suchmann, Donna B; Nims, Raymond W.; Zhou, Sifang

doi:10.4172/1948-5948.1000370

Cited by 2 publications

(1 citation statement)

References 17 publications

(17 reference statements)

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“…The MVM, a member of the family Parvoviridae , was used as an indicator, because it is thermostable, can be propagated and cultivated in permanent cell lines and displays a cytopathic effect on cells. Whereas, contrary to what was stated in the experimental study, cell culture systems are also established for bovine parvovirus (Torgeman et al., 2017) and other parvoviruses relevant for the application, such as porcine parvovirus (Lukula et al., 2017), the BIOHAZ Panel considers MVM as a suitable indicator. In fact, the choice of the MVM virus is supported by a systematic literature review on viral heat inactivation performed by Nims and Plavsic (2013, 2014), in which they support the routine use of parvoviruses such as MVM or PPV as worst‐case virus models for evaluating heat inactivation.…”

Section: Assessmentmentioning

confidence: 80%

Evaluation of alternative methods of tunnel composting (submitted by the European Composting Network) II

Koutsoumanis,

Allende,

Bolton

et al. 2024

EFS2

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Two alternative methods for producing compost in a tunnel, from certain category (Cat.) 3 animal by-products (ABP) and other non-ABP material, were assessed. The first method proposed a minimum temperature of 55°C for 72 h and the second 60°C for 48 h, both with a maximum particle size of 200 mm. The assessment of the Panel on Biological Hazards (BIOHAZ) exclusively focused on Cat. 3 ABP materials (catering waste and processed foodstuffs of animal origin no longer intended for human consumption). The proposed composting processes were evaluated for their efficacy to achieve a reduction of at least 5 log 10 of Enterococcus faecalis and Salmonella Senftenberg (775W, H 2 S negative) and at least 3 log 10 of relevant thermoresistant viruses. The applicant provided a list of biological hazards that may enter the composting process and selected parvoviruses as the indicator of the thermoresistant viruses. The evidence provided by the applicant included: (a) literature data on thermal inactivation of biological hazards; (b) results from validation studies on the reduction of E. faecalis, Salmonella Senftenberg 775W H 2 S negative and canine parvovirus carried out in composting plants across Europe; (c) and experimental data from direct measurements of reduction of infectivity of murine parvovirus in compost material applying the time/temperature conditions of the two alternative methods. The evidence provided showed the capacity of the proposed alternative methods to reduce E. faecalis and Salmonella Senftenberg 775W H 2 S negative by at least 5 log 10 , and parvoviruses by at least 3 log 10 . The BIOHAZ Panel concluded that the two alternative methods under assessment can be considered to be equivalent to the processing method currently approved in the Commission Regulation (EU) No 142/2011.

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Section: Assessmentmentioning

confidence: 80%

Evaluation of alternative methods of tunnel composting (submitted by the European Composting Network) II

Koutsoumanis,

Allende,

Bolton

et al. 2024

EFS2

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Variability and Relative Order of Susceptibility of Non-Enveloped Viruses to Chemical Inactivation

Zhou¹

2022

Disinfection of Viruses

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Viruses exhibit a marked variation in their susceptibilities to chemical and physical inactivation. Identifying a trend within these variations, if possible, could be valuable in the establishment of an effective and efficient infection control or risk mitigation strategy. It has been observed that non-enveloped viruses are generally less susceptible than enveloped viruses and that smaller sized viruses seem less susceptible than larger viruses. A theory of a “hierarchy” of pathogen susceptibility has been proposed and widely referenced. This concept provides a useful general guide for predicting the susceptibility of a newly emerged pathogen. It also serves as a theoretical basis for implementing a limited scale viral inactivation study that is to be extrapolated onto many other viruses. The hierarchy concept should be interpreted with caution since the actual viral inactivation efficacy may, in some cases, be different from the general prediction. The actual efficacy is dependent on the type of chemistry and application conditions. The order of susceptibility is not always fixed; and viruses within the same family or even the same genus may exhibit drastic differences. This chapter reviews viral inactivation data for several commonly used chemistries against non-enveloped viruses, highlighting the cases wherein the order of susceptibility varied or even flipped. Possible underlying mechanisms are also discussed.

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Inactivation and Disinfection of Porcine Parvovirus on a Nonporous Surface

Cited by 2 publications

References 17 publications

Evaluation of alternative methods of tunnel composting (submitted by the European Composting Network) II

Evaluation of alternative methods of tunnel composting (submitted by the European Composting Network) II

Variability and Relative Order of Susceptibility of Non-Enveloped Viruses to Chemical Inactivation

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