Inactivating the infralimbic but not prelimbic medial prefrontal cortex facilitates the extinction of appetitive Pavlovian conditioning in Long-Evans rats

Mendoza, Jesse A.; Sanio, Christian; Chaudhri, Nadia

doi:10.1016/j.nlm.2014.12.006

Cited by 30 publications

(24 citation statements)

References 48 publications

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“…In an appetitive Pavlovian task, inactivation of the ILA, but not the PL, facilitated extinction (Mendoza, Sanio, and Chaudhri, 2015) and studies of renewal with aversive tasks found differences between the PL and ILA (Knapska and Maren, 2009). Selective manipulations of the PL or ILA during context-induced reinstatement of alcohol seeking suggest the PL may be required for retrieval of the learned associations underlying responding, while the ILA is important for contextual information processing (Willcocks and McNally, 2013).…”

Section: Discussionmentioning

confidence: 99%

Sex specific recruitment of a medial prefrontal cortex-hippocampal-thalamic system during context-dependent renewal of responding to food cues in rats

Anderson

Petrovich

2017

Neurobiology of Learning and Memory

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Section: Discussionmentioning

confidence: 99%

Sex specific recruitment of a medial prefrontal cortex-hippocampal-thalamic system during context-dependent renewal of responding to food cues in rats

Anderson

Petrovich

2017

Neurobiology of Learning and Memory

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“…or isoflurane (5% induction; 2–3% maintenance) and implanted permanent guide cannulae (23-gauge, Plastics One, Roanoke, VA) unilaterally 1 mm above NAc shell or vmPFC and 1 mm above the vSub in the ipsilateral or contralateral hemisphere. The stereotaxic coordinates (Paxinos and Watson 2008) are based on our and others‘ previous work (Bossert and Stern 2014; Bossert et al 2012; Mendoza et al 2015). The coordinates (nosebar set at -3.3 mm) for the different brain areas were for contralateral vmPFC: AP +3.0 mm, ML ±1.5 mm (10° angle), and DV 4.3 mm; for ipsilateral vmPFC: AP +3.0 mm, ML ±0.6 mm, and DV 4.1 mm; for contralateral NAc shell: AP +1.6 mm, ML ±3.0 mm (20° angle), and DV −6.5 mm, for ipsilateral NAc shell: AP +1.6 mm, ML ±1.6 mm (20° angle), and DV −7.2 mm (note that because of stereotaxic constraints, cannula for ipsilateral NAc shell were inserted at a 20° angle from the contralateral hemisphere through the midline (Bossert et al 2012; Ikemoto et al 2005)); and for vSub: AP −6.0 mm, ML ±5.3 mm (4° angle), and DV −7.5 mm.…”

Section: Methodsmentioning

confidence: 99%

Role of projections from ventral subiculum to nucleus accumbens shell in context-induced reinstatement of heroin seeking in rats

et al. 2015

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Rationale and objective In humans, exposure to contexts previously associated with heroin use can provoke relapse. In rats, exposure to heroin-paired contexts after extinction of drug-reinforced responding in different contexts reinstates heroin seeking. We previously demonstrated that the projections from ventral medial prefrontal cortex (vmPFC) to nucleus accumbens (NAc) shell play a role in this reinstatement. The ventral subiculum (vSub) sends glutamate projections to NAc shell and vmPFC. Here, we determined whether these projections contribute to context-induced reinstatement. Methods We trained rats to self-administer heroin (0.05–0.1 mg/kg/infusion) for 3 h per day for 12 days; drug infusions were paired with a discrete tone-light cue. Lever pressing in the presence of the discrete cue was subsequently extinguished in a different context. We then tested the rats for reinstatement in the heroin- and extinction-associated contexts under extinction conditions. We combined Fos with the retrograde tracer Fluoro-Gold (FG) to determine projection-specific activation during the context-induced reinstatement tests. We also used anatomical disconnection procedures to determine whether the vSub→NAc shell and vSub→vmPFC projections are functionally involved in this reinstatement. Results Exposure to the heroin but not the extinction context reinstated lever pressing. Context-induced reinstatement of heroin seeking was associated with increased Fos expression in vSub neurons, including those projecting to NAc shell and vmPFC. However, anatomical disconnection of the vSub→NAc shell projection, but not the vSub→vmPFC projection, decreased this reinstatement. Conclusions Our data indicate that the vSub→NAc shell glutamatergic projection, but not the vSub→vmPFC projection, contributes to context-induced reinstatement of heroin seeking.

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“…In particular, the topography of specific subsystems between these three large forebrain regions is unknown. This is especially critical given that the amygdala, mPFC and LHA are complex heterogeneous regions comprised of distinct cell groups that mediate different functions (e.g., Ashwell and Ito 2014; Burgos-Robles et al 2013; Cole et al 2013; Heidbreder and Groenewegen 2003; Knapska et al 2012; Maeng and Shors 2013; Martinez et al 2013; Mendoza et al 2014; Senn et al 2014; Swanson and Petrovich 1998). Prior work, with anterograde or retrograde tracing methods, has identified direct pathways from the amygdala to the mPFC and to the LHA, as well as direct pathways from the mPFC to the LHA (e.g., Hoover and Vertes 2007; Hurley et al 1991; Kita and Oomura 1982; Krettek and Price 1977b, 1978; Ono et al 1985; Sesack et al 1989), including the mid-rostrocaudal (tuberal) LHA region which contains orexigenic neuropeptides (Broberger et al 1998; Hahn 2010; Swanson et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Organization of connections between the amygdala, medial prefrontal cortex, and lateral hypothalamus: a single and double retrograde tracing study in rats

2015

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The amygdala and medial prefrontal cortex (mPFC) are highly interconnected telencephalic areas critical for cognitive processes, including associative learning and decision making. Both structures strongly innervate the lateral hypothalamus (LHA), an important component of the networks underlying the control of feeding and other motivated behaviors. The amygdala–prefrontal–lateral hypothalamic system is therefore well positioned to exert cognitive control over behavior. However, the organization of this system is not well defined, particularly the topography of specific circuitries between distinct cell groups within these complex, heterogeneous regions. This study used two retrograde tracers to map the connections from the amygdala (central and basolateral area nuclei) and mPFC to the LHA in detail, and to determine whether amygdalar pathways to the mPFC and to LHA originate from the same or different neurons. One tracer was placed into a distinct mPFC area (dorsal anterior cingulate, prelimbic, infralimbic, or rostromedial orbital), and the other into dorsal or ventral LHA. We report that the central nucleus and basolateral area of the amygdala send projections to distinct LHA regions, dorsal and ventral, respectively. The basolateral area, but not central nucleus, also sends substantial projections to the mPFC, topographically organized rostrocaudal to dorsoventral. The entire mPFC, in turn, projects to the LHA, providing a separate route for potential amygdalar influence following mPFC processing. Nearly all amygdalar projections to the mPFC and to the LHA originated from different neurons suggesting amygdala and amygdala–mPFC processing influence the LHA independently, and the balance of these parallel pathways ultimately controls motivated behaviors.

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Inactivating the infralimbic but not prelimbic medial prefrontal cortex facilitates the extinction of appetitive Pavlovian conditioning in Long-Evans rats

Cited by 30 publications

References 48 publications

Sex specific recruitment of a medial prefrontal cortex-hippocampal-thalamic system during context-dependent renewal of responding to food cues in rats

Sex specific recruitment of a medial prefrontal cortex-hippocampal-thalamic system during context-dependent renewal of responding to food cues in rats

Role of projections from ventral subiculum to nucleus accumbens shell in context-induced reinstatement of heroin seeking in rats

Organization of connections between the amygdala, medial prefrontal cortex, and lateral hypothalamus: a single and double retrograde tracing study in rats

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