Inactivated Measles-Virus Vaccine: A Field Evaluation

Foege, William H.; Leland, O. S.; Mollohan, C. S.; Fulginiti, V. A.; Henderson, Donald A.; Kempe, C. H.

doi:10.2307/4592354

Cited by 7 publications

(2 citation statements)

References 10 publications

(9 reference statements)

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“…In the 1960s, classical inactivated measles vaccines were manufactured by formalin inactivation of whole MV preparations, which were subsequently precipitated with aluminum salts (referred to as FI-MV). Initially, vaccination with FI-MV was shown to induce MV-specific serum antibody responses (Hilleman et al 1962;Norrby et al 1964;Foege et al 1965), and the vaccine was used in large-scale clinical trials in humans. However, after a number of years it turned out that vaccination predisposed for enhanced disease upon natural MV infection, which was referred to as atypical measles (Fulginiti et al 1967) (see also chapter 10).…”

Section: Atypical Measlesmentioning

confidence: 99%

Measles Studies in the Macaque Model

Swart

2009

Current Topics in Microbiology and Immunology

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Much of our current understanding of measles has come from experiments in non-human primates. In 1911, Goldberger and Anderson showed that macaques inoculated with filtered secretions from measles patients developed measles, thus demonstrating that the causative agent of this disease was a virus. Since then, different monkey species have been used for experimental measles virus infections. Moreover, infection studies in macaques demonstrated that serial passage of the virus in vivo and in vitro resulted in virus attenuation, providing the basis for all current live-attenuated measles vaccines. This chapter will review the macaque model for measles, with a focus on vaccination and immunopathogenesis studies conducted over the last 15 years. In addition, recent data are highlighted demonstrating that the application of a recombinant measles virus strain expressing enhanced green fluorescent protein dramatically increased the sensitivity of virus

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Section: Atypical Measlesmentioning

confidence: 99%

Measles Studies in the Macaque Model

Swart

2009

Current Topics in Microbiology and Immunology

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“…Further research yielded the current well-tolerated vaccines. Inactivated measles-virus vaccines had also been licensed in 1963 based on safety, immunogenicity, and short-term efficacy data [60]. However, immunity was short-lived; postlicensure surveillance revealed that some vaccine recipients developed a syndrome of atypical measles when subsequently exposed to wild measles virus [61],[62].…”

Section: Lesson 5 the Pivotal Role Of Vaccines As A Tool For Diseasementioning

confidence: 99%