Inaccuracy of Estimated Creatinine Clearance for Prediction of lothalamate Glomerular Filtration Rate

Rolin, Henry A.; Hall, Phillip M.; Wei, R.

doi:10.1016/s0272-6386(84)80026-8

Cited by 80 publications

(34 citation statements)

References 11 publications

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“…The methods usually employed in hospitalized patients are serum creatinine and endogenous creatinine clearance. However, they both have important limitations (1)(2)(3). The production rate and tubular secretion of creatinine may be substantially altered in hospitalized patients due to associated comorbidities and/or drug therapy.…”

Section: Introductionmentioning

confidence: 99%

“…The production rate and tubular secretion of creatinine may be substantially altered in hospitalized patients due to associated comorbidities and/or drug therapy. The endogenous creatinine clearance tends to overestimate the glomerular filtration rate GFR as renal insufficiency progresses and is subject to error depending on samples collection method (1)(2)(3).…”

Section: Introductionmentioning

confidence: 99%

“…In comparison to the IDMS-MDRD equation, CKD-EPI has greater precision and reliability, especially for glomerular filtration rates Ͼ60 ml/min per 1.73 m 2 . However, to date, this equation has not been evaluated in hospitalized patients.…”

Section: Introductionmentioning

confidence: 99%

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Assessing Glomerular Filtration Rate in Hospitalized Patients

Segarra¹,

Torre²,

Ramos³

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives A specific method is required for estimating glomerular filtration rate GFR in hospitalized patients. Our objective was to validate the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and four cystatin C (CysC)-based equations in this setting.Design, setting, participants, & measurements This was an epidemiologic, cross-sectional study in a random sample of hospitalized patients (n ϭ 3114). We studied the accuracy of the CKD-EPI and four CysC-based equations-based on (1) CysC alone or (2) adjusted by gender; (3) age, gender, and race; and (4) age, gender, race, and creatinine, respectively-compared with GFR measured by iohexol clearance (mGFR). Clinical, biochemical, and nutritional data were also collected.Results The CysC equation 3 significantly overestimated the GFR (bias of 7.4 ml/min per 1.73 m 2 ). Most of the error in creatinine-based equations was attributable to calculated muscle mass, which depended on patient's nutritional status. In patients without malnutrition or reduced body surface area, the CKD-EPI equation adequately estimated GFR. Equations based on CysC gave more precise mGFR estimates when malnutrition, extensive reduction of body surface area, or loss of muscle mass were present (biases of 1 and 1.3 ml/min per 1.73 m 2 for equations 2 and 4, respectively, versus 5.9 ml/min per 1.73 m 2 for CKD-EPI). ConclusionsThese results suggest that the use of equations based on CysC and gender, or CysC, age, gender, and race, is more appropriate in hospitalized patients to estimate GFR, since these equations are much less dependent on patient's nutritional status or muscle mass than the CKD-EPI equation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessing Glomerular Filtration Rate in Hospitalized Patients

Segarra¹,

Torre²,

Ramos³

et al. 2011

Clinical Journal of the American Society of Nephrology

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“…Hypertensive patients treated with anti-hypertension drugs, may have suffered renal auto-regulation influence, without changing plasma creatinine. It is known that Cockcroft and Gault's formula 8 overestimates glomerular filtration rate in special situations 16 . This is a point demanding further studies.…”

Section: Resultsmentioning

confidence: 99%

Avaliação da função renal do idoso em duas horas

Benarab¹,

Castiglia²,

Vianna³

et al. 2005

Rev. Bras. Anestesiol.

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“…34) A previous study compared iothalamate-determined GFR against EGFR values and reported an acceptable correlation of 0.93. 15) …”

Section: Discussionmentioning

confidence: 99%

<b>Effect of Renal Artery Stenting on Renal Function in Patients With Ischemic Nephropathy</b>

İlkay¹,

Günal²,

Yavuzkır³

et al. 2004

Jpn Heart J

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SUMMARYThe aim of this study was to evaluate the effects of stenting on blood pressure and renal functions in azotemic patients with proximal/ostial atherosclerotic renal artery stenosis.Thirteen azotemic patients (5 females, 8 males, average age, 62.7 ± 8.3 years) who had renal artery stenosis were included in the study. Their blood pressure, estimated glomerular filtration rate (EGFR), and creatinine levels were measured at baseline and during follow-up.Stents were implanted successfully in all of the cases. The average stent diameter and stent length were 7.2 ± 0.5 mm and 17.2 ± 3.4 mm, respectively. Antihypertensive drug was abandoned in 1 (7.6%) patient, reduced in 10 patients (76.9%), and not changed in 2 (15.3%) patients. Significant improvement was observed in the mean serum creatinine level at the 12 th month when compared with baseline (2.56 ± 0.88; 1.83 ± 0.62, P < 0.001). EGFR was 18.38 ± 4.64 before the procedure and 22.67 ± 3.81 during follow-up (P < 0.0001). According to the EGFR criteria, renal function was determined to be worse in 1 (7.6%) patient, stabilized in 2 (15.3%), and improved in 10 (76.9%) patients. One patient died during the follow-up period. Angiographic restenosis was observed in 2 (15.3%) patients. Follow-up major events were observed in 3 (23%) patients.Stenting azotemic patients with renal artery stenosis is a reliable and effective procedure for achieving an improvement in renal function. (Jpn Heart J 2004; 45: 637-645)

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Inaccuracy of Estimated Creatinine Clearance for Prediction of lothalamate Glomerular Filtration Rate

Cited by 80 publications

References 11 publications

Assessing Glomerular Filtration Rate in Hospitalized Patients

Assessing Glomerular Filtration Rate in Hospitalized Patients

Avaliação da função renal do idoso em duas horas

<b>Effect of Renal Artery Stenting on Renal Function in Patients With Ischemic Nephropathy</b>

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