Inaccuracy of basal body temperature charts in predicting urinary luteinizing hormone surges

Quagliarello, John; Arny, M.

doi:10.1016/s0015-0282(16)49212-5

Cited by 50 publications

(22 citation statements)

References 22 publications

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“…The association found between the urinary LH surge detection and the basal body temperature nadir is in agreement with data in the literature (23,24) and reconfirms the inadequacy of this parameter in predicting ovulation. Nevertheless, it has a practical complementary value for the monitoring of the cycle.…”

Section: Discussionsupporting

confidence: 90%

“…The occurrence of only one single decoloured test was observed in 29 of (31%) of spontaneous, 29 (25%) of clomiphene citrate-and 17 (24%) hMG-stimulated cycles. Its distribution either in morning or evening urine samples was 9 and 20, 17 and 12, and 8 [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] in the hMG cycles. Statistical analysis demonstrated that follicles from clomiphene citrate-induced cycles had reached a significantly larger diameter as com¬ pared with the other two groups (p<0.001).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Urinary luteinizing hormone testing and prediction of ovulation in spontaneous, clomiphene citrate and human menopausal gonadotropin-stimulated cycles. A clinical evaluation

Martínez

Bernardus²,

Kucharska³

et al. 1991

Acta Endocrinologica

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A urinary luteinizing hormone test was utilized to predict ovulation in 99 spontaneous, 122 clomiphene citrate, and 82 human menopausal gonadotropin stimulated cycles. Tests were performed in early morning and evening specimens and follicular development was monitored by daily ultrasonography. A positive detection rate of 98, 97, and 94%, respectively, was obtained. Evidence of luteinized unruptured follicles was seen more frequently in stimulated cycles, concurring with negative test results. In 2 spontaneous, 1 clomiphene citrate and 5 hMG induced cycles two distinct LH surges were detected concomitant with a pattern of follicular atresia and subsequent new follicular development. Most ovulations occurred between 16 and 28 h after LH detection, signficantly earlier in spontaneous than in clomiphene citrate stimulated cycles (p<0.02), whereas pre-ovulatory follicles were larger in the clomiphene citrate group (p<0.001). The mean duration of the follicular and luteal phases, as calculated from the LH peak, was substantially shorter in the hMG cycles than in the other two groups (p<0.001).Ovulation is a cardinal event in reproduction and accurate prediction of the time of ovulation is a cornerstone in the management of infertile cou¬ ples. Among many investigated parameters, the lu¬ teinizing hormone surge in serum or plasma has qualified as the most reliable predictor of ovulation (1,2). Moreover, since LH is rapidly excreted, the rise in the concentration of UH in urine provides a useful indicator of the fertile period in women (3,4). The recent introduction of rapid tests for urinary UH surge detection has offered a new valu¬ able clinical tool for determining the moment of optimal fertility (5). However, little is known about its applicability in stimulated cycles and its correla¬ tion with midcycle events when compared with the normal cycles.In the present study the UH Color, a direct ag¬ glutination tube test based on the Sol Particle Immunoassay (SPIA) technology, was used to detect the pre-ovulatory urinary LH surge in spontane¬ ous, clomiphene citrate and human menopausal gonadotropin (hMG) stimulated cycles. The aim of the investigation was to estimate the effectiveness of the test to detect the urinary LH surge and pre¬ dict ovulation. In addition, the characteristics of the observed surge and its relation with follicular events as evidenced by daily ultrasonography and basal body temperature records, were compared between the three different modalities. Subjects and MethodsOne hundred and fifteen women between the ages of 21 and 39 years (mean 32, sd±3.5) participated in the study. Patients were suffering from idiopathic (N=69), male (N=42) or cervical factor (N=4) infertility and either intrauterine insemination or natural intercourse were timed following the detection of a urinary LH surge. All had undergone a basic fertility work-up and were having regular ovulatory cycles as confirmed by basal body tem¬ perature records and late luteal phase endometrial biop¬ sies.A total of 303 cycles were analyse...

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Section: Discussionsupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Urinary luteinizing hormone testing and prediction of ovulation in spontaneous, clomiphene citrate and human menopausal gonadotropin-stimulated cycles. A clinical evaluation

Martínez

Bernardus²,

Kucharska³

et al. 1991

Acta Endocrinologica

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“…The test's accuracy, however, is questionable. Studies place the ability of BBT to precisely predict the LH surge to the day at 18.3%-30% and to within 1 day at 56.7%-70% (6). However, not all women display a clear shift in BBT after ovulation and conditions including illness, changes in sleep patterns, alcohol consumption, and certain medications may alter the BBT (4,7).…”

Section: Basal Body Temperaturementioning

confidence: 99%

At home testing: optimizing management for the infertility physician

Brezina

Haberl

Wallach

2011

Fertility and Sterility

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“…Basal body temperature is based upon a postovulatory rise (or shift) in body temperature due to an increase in the hormone progesterone (Barron & Fehring, 2005). While BBT is inexpensive and easy to use, it is often an imprecise predictor or indicator of ovulation (Guida et al, 1999; McCarthy & Rockette, 1983; Quagliarello & Arny, 1986). Body temperature can also rise due to other phenomena such as stress, disrupted sleep patterns, and infection.…”

Section: Background Studiesmentioning

confidence: 99%

Efficacy of Cervical Mucus Observations Plus Electronic Hormonal Fertility Monitoring as a Method of Natural Family Planning

Fehring

Schneider

Raviele³

et al. 2007

Journal of Obstetric, Gynecologic & Neonatal Nursing

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Abstract:Objective: To determine the effectiveness of an electronic hormonal fertility monitor plus cervical mucus monitoring to avoid pregnancy. Design: A 12-month prospective clinical efficacy trial. Setting and Participants:One hundred ninety-five (195) Conclusions: Correct use of an electronic hormonal fertility monitor with cervical mucus observations can be as effective as other fertility awareness -based methods of natural family planning. Comparative studies are needed to confirm this conclusion.Approximately 124,000 women in the United States use natural methods of family planning (i.e., cervical mucus or temperature monitoring) for avoiding pregnancy (Mosher, Martinez, Chandra, Abma, & Wilson, 2004). Another 434,000 use self-devised calendar formulas (i.e., rhythm) as a means to avoid pregnancy. Many women rely on natural markers of fertility to help them achieve pregnancy. The accuracy, ease of use, acceptability, and effectiveness of natural biological markers to estimate the time of fertility in the menstrual cycle is important for these women. When NFP methods are used according to instructions (which is referred to as correct use), the unintended pregnancy rate can be as low as 1 to 3 per 100 users over a 12-month time period, and when the instructions are not always followed (which is called imperfect use), the unintended pregnancy rate can be as high as 25 per 100 users over 12 months (Trussell, 2004). The large difference between correct-and imperfect-use unintended pregnancy rates is due to the considerable overestimation of the 6-day fertile window (when correct use is calculated) and to difficulties in the complexity of learning and using NFP methods, the length of required abstinence, subjectivity of the biological markers to estimate the fertile window, and variability of the menstrual cycle (Burkman, 2002 ;Trussell).The purpose of this study was to determine the effectiveness of using a new high-tech hormonal fertility monitor called the Clearblue Easy Fertility Monitor (CEFM) (Inverness Medical Innovations, Waltham, MA) along with another natural marker of fertility (i.e., cervical mucus monitoring) as a means to avoiding pregnancy. The CEFM is a handheld home-use device that estimates fertility by measuring urinary metabolites of estrogen and luteinizing hormone (LH) (May, 2001). The monitor is intended as an aid for achieving pregnancy. However, it could be useful for women and couples who wish to avoid pregnancy as well. Background Studies

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Inaccuracy of basal body temperature charts in predicting urinary luteinizing hormone surges

Cited by 50 publications

References 22 publications

Urinary luteinizing hormone testing and prediction of ovulation in spontaneous, clomiphene citrate and human menopausal gonadotropin-stimulated cycles. A clinical evaluation

Urinary luteinizing hormone testing and prediction of ovulation in spontaneous, clomiphene citrate and human menopausal gonadotropin-stimulated cycles. A clinical evaluation

At home testing: optimizing management for the infertility physician

Efficacy of Cervical Mucus Observations Plus Electronic Hormonal Fertility Monitoring as a Method of Natural Family Planning

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