In women with endometriosis anti-Mullerian hormone levels are decreased only in those with previous endometrioma surgery

Streuli, Isabelle; Ziegler, Dominique de; Gayet, Vanessa; Santulli, Piétro; Bijaoui, G; Mouzon, J. de; Chapron, Charles

doi:10.1093/humrep/des274

Cited by 143 publications

(102 citation statements)

References 47 publications

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“…Moreover, our findings support earlier studies on infertility in women with endometriosis (37,38), excluding a possible direct effect of ectopically produced AMH on ovarian reserve of women with endometriosis.…”

Section: Discussionsupporting

confidence: 91%

Increased expression of antimüllerian hormone and its receptor in endometriosis

Carrarelli

Rocha

Belmonte

et al. 2014

Fertility and Sterility

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Objective: To evaluate antim€ ullerian hormone (AMH) and AMH receptor II (AMHRII) mRNA and protein expression in endometrium and in ovarian or deep lesions of women with endometriosis. Design: Prospective study. Setting: University hospitals in Italy and Brazil. Patients: Patients with endometriosis (n ¼ 55) and healthy women (n ¼ 45). Interventions: Specimens of endometrium obtained by hysteroscopy from patients with endometriosis and from healthy control subjects; specimens of ovarian endometriosis (n ¼ 29) or of deep endometriosis (n ¼ 26) were collected by laparoscopy. Serum samples were collected in some endometriotic patients (n ¼ 23) and healthy control subjects (n ¼ 20). Main Outcome Measure(s): AMH and AMHRII mRNA levels were evaluated by quantitative reverse-transcription polymerase chain reaction and protein localization by immunohistochemistry. AMH levels in tissue homogenates and in serum were assessed by ELISA. Result(s): Endometrium from women with endometriosis showed higher AMH and AMHRII mRNA levels than control women, with no significant differences between proliferative and secretory phases. Specimens collected from ovarian or deep endometriosis showed the highest AMH and AMHRII mRNA expression. Immunolocalization study confirmed the high AMH and AMHRII protein expression in endometriotic lesions. No difference of serum AMH levels between the groups was found. Conclusion(s):The increased AMH and AMHRII mRNA and protein expression in endometrium and in endometriotic lesions suggests a possible involvement of AMH in endometriosis.

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Section: Discussionsupporting

confidence: 91%

Increased expression of antimüllerian hormone and its receptor in endometriosis

Carrarelli

Rocha

Belmonte

et al. 2014

Fertility and Sterility

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“…Remarkable declines in serum AMH were reported in patients with moderate to sever endometriosis, which was more pronounced in those with bilateral endometrioma. 25,[31][32][33][34][35][36] Ovaries with endometrioma may already have some damage with decreased ovarian reserve. [24][25][26] Lower anti-mullerian hormone serum levels and association with the severity of the disease found in women with endometriosis.…”

Section: Discussionmentioning

confidence: 99%

Endometrioma is a Responsible Factor for Reduced Ovarian Reserve

Begum

Ehsan²,

Ehsan³

et al. 2016

Bangladesh J Obstet Gynaecol

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Objective (s): The aim of the study was to assess ovarian reserve (OR) of patients with endometrioma and to explore the differences of ovarian reserve in age matched group of infertile patients without endometrioma.Materials and methods: This prospective analytic study was done in Infertility Care and Research Center, between January 2013 and December 2015 to assess the ovarian reserve of patients with endometrioma. During this period 105 patients of endometriosis with endometrioma were selected for study. Selection criteria were: no history of previous surgery, <36 years of age, no history of endocrine problems, no history of recent medical treatment for this condition within 6 months and no history of irregular menstruation. For ovarian reserve testing we assessed serum FSH, E2 and AMH. Patient of same age group who had no emdometrioma, no history of any surgery, no menstrual irregularity, endocrine disorder or any other medical diseases were taken as control to compare the ovarian reserve between these two groups. For control group also we did the same tests. Data was analyzed by SPSS package. One-way ANOVA test was done for test of significance. A p-value of <0.05 was considered as significant.Results: There was no difference in characteristics of patients of both groups regarding age, type of infertility and duration of infertility. Size of the endometriotic cysts were variable and average diameter of cyst was 6.2 ±2.32 cm. Most (58.10%) of the cysts were unilateral. There is a significant difference of FSH and AMH level between the groups. FSH of endometrioma and non-endometrioma group was 7.9 ±1.17 and 7.1 ±1.05 mIU/mL respectively with a p value of 0.029. Similar difference was present in AMH level, which was 2.42 ±.63 and 2.98 ±.88 ng/ mL in endometrioma and non-endometrioma group respectively with a p value of 0.020.Conclusion: This small study shows a reduced ovarian reserve in patients with endometrioma in comparison to patients of same parameters without endometrioma. It suggests that there is an association of presence of ovarian endometrioma and reduced ovarian reserveBangladesh J Obstet Gynaecol, 2015; Vol. 30(2) : 98-104

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“…413 healthy controls [ 22 ]. The authors reported no differences in serum AMH levels between patients and controls (endometriosis vs .…”

Section: Anti-müllerian Hormone (Amh)mentioning

confidence: 90%