In VivoEvidence for the Involvement of Dopamine-D2Receptors in Striatum and Anterior Cingulate Gyrus in Major Depression

Larisch, Rolf; Klimke, A.; Vosberg, H.; Löffler, Susanne; Gäebel, Wolfgang; Müller‐Gärtner, Hans‐Wilhelm

doi:10.1006/nimg.1997.0267

Cited by 100 publications

(54 citation statements)

References 32 publications

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“…Imaging studies on SSRI effect in normal subjects reported: (a) increase (Dewey et al, 1995;Penttilä et al, 2004), (b) no changes (Fowler et al, 1999), or (c) decrease (Tiihonen et al, 1996) in D 2 receptors availability. In agreement with the results of our study, an increase in D 2 receptors availability was observed in patients with major depression responder to SSRIs therapy but not in nonresponder patients (Klimke et al, 1999;Larisch et al, 1997). In the present study on OCD patients, we failed to find any correlations between the degree of clinical response and the increase in tracer BP.…”

Section: Discussionsupporting

confidence: 92%

“…A modification in D 2 receptors availability has been observed in patients suffering from major depression treated with SSRI. An increased D 2 receptor availability has been demonstrated in the striatum and anterior cingulate gyrus of unipolar depressed patients responders to SSRI treatment but not in nonresponder patients (Klimke et al, 1999;Larisch et al, 1997).…”

Section: Introductionmentioning

confidence: 96%

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Fluvoxamine Treatment and D2 Receptors: a Pet Study on OCD Drug-Naïve Patients

Moresco

Pietra

Henin

et al. 2006

Neuropsychopharmacol

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Changes in D 2 receptors during antidepressant therapy have been reported in patients with major depressive disorder using PET/SPET. The aim of this study was to evaluate modifications in D 2 receptors that might occur in patients affected by obsessive-compulsive disorder (OCD) during serotonin reuptake sites inhibitors (SSRIs). To this purpose, we measured the in vivo binding of [ 11 C]raclopride ([ 11 C]Rac)in the brain of a group of OCD naïve patients before and after the repeated administration of the inhibitor SSRI fluvoxamine. Eight patients with a Diagnostic and Statistical Manual of Mental Disorders IVth edition diagnosis of OCD completed the study undergoing a PET scan and a complete clinical evaluation before and during treatment with fluvoxamine. Patients have been compared also with a group of nine age-matched normal volunteers. Fluvoxamine treatment significantly improved clinical symptoms and increased [ 11 C]Rac binding potential (BP) in the basal ganglia of OCD patients (7.575.2, 6.976.9, and 9.979.3% in dorsal caudate, dorsal putamen, and ventral basal ganglia, respectively; po0.01) to values closer to those observed in the group of normal subjects. Chronic treatment with fluvoxamine induces a slight but significant increase in striatal [ 11 C]Rac BP of previously drug-naïve OCD patients. The modifications in D 2 receptor availability might be secondary to fluvoxamine effects on serotoninergic activity.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 96%

Fluvoxamine Treatment and D2 Receptors: a Pet Study on OCD Drug-Naïve Patients

Moresco

Pietra

Henin

et al. 2006

Neuropsychopharmacol

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“…Animal and human studies show that the dopaminergic system has an important role in modulating the prefrontal activation during working memory. [63][64][65][66] The dysfunction of the frontal cortex systems in subjects with MDD was reported in positron emission tomography and single photon emission tomography studies, [67][68][69][70] although there is no study, to our knowledge, that investigated the direct relation between the dopaminergic system and working memory in MDD patients. The dysfunction of the dopaminergic system in MDD patients may underlie the abnormal function of the frontolimbic network in the process of working memory reported in our present study and others.…”

Section: Working Memory In Depression K Matsuo Et Almentioning

confidence: 99%

“…The dysfunction of the dopaminergic system in MDD patients may underlie the abnormal function of the frontolimbic network in the process of working memory reported in our present study and others. [67][68][69][70] Our study has some methodological limitations, including the relatively modest sample size and the fact that our sample included patients with comorbid anxiety disorders. The ACC activation we observed in the MDD patients may include the influence of anxiety symptoms, because the anatomical pathophysiology of anxiety disorders involves the hippocampus, amygdala and ACC, [71][72][73] and patients with anxiety disorders also show a deficit of working memory.…”

Section: Working Memory In Depression K Matsuo Et Almentioning

confidence: 99%

Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder

et al. 2006

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The prefrontal cortex, a part of the limbic-thalamic-cortical network, participates in regulation of mood, cognition and behavior and has been implicated in the pathophysiology of major depressive disorder (MDD). Many neuropsychological studies demonstrate impairment of working memory in patients with MDD. However, there are few functional neuroimaging studies of MDD patients during working memory processing, and most of the available ones included medicated patients or patients with both MDD and bipolar disorder. We used functional magnetic resonance imaging (fMRI) to measure prefrontal cortex function during working memory processing in untreated depressed patients with MDD. Fifteen untreated individuals with Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition recurrent MDD (mean age7s.d. = 34.3711.5 years) and 15 healthy comparison subjects (37.7712.1 years) matched for age, sex and race were studied using a GE/Elscint 2T MR system. An echo-planar MRI sequence was used to acquire 24 axial slices. The n-back task (0-back, 1-back and 2-back) was used to elicit frontal cortex activation. Data were analyzed with a multiple regression analysis using the FSL-FEAT software. MDD patients showed significantly greater left dorsolateral cortex activation during the n-back task compared to the healthy controls (P < 0.01), although task performance was similar in the two groups. Furthermore, the patients showed significant anterior cingulate cortex activation during the task, but the comparison subjects did not (P < 0.01). This study provides in vivo imaging evidence of abnormal frontolimbic circuit function during working memory processing in individuals with MDD.

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“…Matters, however, are different in clinical investigations of D 2 receptor binding, where cerebellar (e.g. [28][29][30]) and cortical REFs (e.g. [31][32][33]), have been used to the same extent.…”

Section: Introductionmentioning

confidence: 99%

Quantification of D2 Receptor Binding in the Rat Striatum Using Small Animal PET - The Impact of the Reference Tissue on the Binding Potential of [18F]N-Methyl-Benperidol

Nikolaus¹,

Larisch²,

Beu³

et al. 2009

TONMEDJ

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Abstract:In the present study, the binding potential (BP) of the D 2 receptor radioligand [18 F]N-methyl-benperidol ([ 18 F]FMB) was determined with in vivo saturation binding analysis using either cerebellum or parietal cortex as reference region. For the purpose of validation, BP additionally was determined in the same set of animals by computing the equilibrium ratios of the distribution volumes (V 3 ''). With in vivo saturation binding analysis, the striatal BP as obtained with a cortical estimate for the free and non-specifically bound radioligand fell short of the BP as obtained with a cerebellar estimate by 70%. Similarly, with the equilibrium distribution volume method, the employment of a cortical REF led to a striatal V 3 '', which was 30% lower than the V 3 '' obtained with a cerebellar REF.

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In VivoEvidence for the Involvement of Dopamine-D2Receptors in Striatum and Anterior Cingulate Gyrus in Major Depression

Cited by 100 publications

References 32 publications

Fluvoxamine Treatment and D2 Receptors: a Pet Study on OCD Drug-Naïve Patients

Fluvoxamine Treatment and D2 Receptors: a Pet Study on OCD Drug-Naïve Patients

Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder

Quantification of D2 Receptor Binding in the Rat Striatum Using Small Animal PET - The Impact of the Reference Tissue on the Binding Potential of [18F]N-Methyl-Benperidol

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