In Vivo X-Ray Fluorescence Analysis with Applications to Platinum, Gold and Mercury in Man — Experiments, Improvements, and Patient Measurements

Börjesson, Johan; Alpsten, M.; Shi-bin, Huang; Jonson, R.; Mattsson, Sören; Thornberg, Charlotte

doi:10.1007/978-1-4899-1268-8_61

Cited by 18 publications

(8 citation statements)

References 8 publications

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“…The improvement can also be made in XFCT by using a cone beam geometry. 23 Future work includes optimizing the imaging geometry using a polarized x-ray source (to reduce the interference of scatter photons 17,19,24 ), and a pixelated CZT photon-counting detector panel (to shorten imaging time) with square-hole pixelated collimator. The spectrum and data analysis algorithms will also be improved.…”

Section: Resultsmentioning

confidence: 99%

Development of XFCT imaging strategy for monitoring the spatial distribution of platinum‐based chemodrugs: Instrumentation and phantom validation

et al. 2013

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Purpose: Developing an imaging method to directly monitor the spatial distribution of platinumbased (Pt) drugs at the tumor region is of critical importance for early assessment of treatment efficacy and personalized treatment. In this study, the authors investigated the feasibility of imaging platinum (Pt)-based drug distribution using x-ray fluorescence (XRF, a.k.a. characteristic x ray) CT (XFCT). Methods: A 5-mm-diameter pencil beam produced by a polychromatic x-ray source equipped with a tungsten anode was used to stimulate emission of XRF photons from Pt drug embedded within a water phantom. The phantom was translated and rotated relative to the stationary pencil beam in a first-generation CT geometry. The x-ray energy spectrum was collected for 18 s at each position using a cadmium telluride detector. The spectra were then used for the K-shell XRF peak isolation and sinogram generation for Pt. The distribution and concentration of Pt were reconstructed with an iterative maximum likelihood expectation maximization algorithm. The capability of XFCT to multiplexed imaging of Pt, gadolinium (Gd), and iodine (I) within a water phantom was also investigated. Results: Measured XRF spectrum showed a sharp peak characteristic of Pt with a narrow full-width at half-maximum (FWHM) (FWHM Kα1 = 1.138 keV, FWHM Kα2 = 1.052 keV). The distribution of Pt drug in the water phantom was clearly identifiable on the reconstructed XRF images. Our results showed a linear relationship between the XRF intensity of Pt and its concentrations (R 2 = 0.995), suggesting that XFCT is capable of quantitative imaging. A transmission CT image was also obtained to show the potential of the approach for providing attenuation correction and morphological information. Finally, the distribution of Pt, Gd, and I in the water phantom was clearly identifiable in the reconstructed images from XFCT multiplexed imaging. Conclusions: XFCT is a promising modality for monitoring the spatial distribution of Pt drugs. The technique may be useful in tailoring tumor treatment regimen in the future. © 2013 American Association of Physicists in Medicine. [http://dx

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Section: Resultsmentioning

confidence: 99%

Development of XFCT imaging strategy for monitoring the spatial distribution of platinum‐based chemodrugs: Instrumentation and phantom validation

et al. 2013

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“…It is known that several drugs contain heavy elements in their chemical composition [121,122] [126]. Sr-based drugs increase bone mass in postmenopausal osteoporosis patients and reduce fracture risk [127][128][129][130][131].…”

Section: Highlighting Heavy Elements In Drugsmentioning

confidence: 99%

The crucial contribution of X-ray fluorescence spectroscopy in medicine

Bazin¹,

Foy²,

Réguer³

et al. 2022

Comptes Rendus. Chimie

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This contribution tries to indicate to the clinician what kind of information can be investigated through X-ray fluorescence, what kind of information can be extracted from this spectroscopy and finally how it competes with other tools described in previous publications such as Fourier Transform Infrared or Raman spectroscopy, X-ray Absorption Near Edge Structure spectroscopy and X-ray diffraction. To attain this goal, several examples based on X-ray fluorescence experiments performed on biological samples namely concretions, medical devices, biological fluids as well as tissues are presented.Résumé. Cette contribution vise à sensibiliser le clinicien sur l'utilisation de la spectroscopie de fluorescence X en précisant le type d'échantillon pouvant être étudié et les informations exploitables. De plus, la complémentarité avec d'autres techniques analytiques présentées dans des publications précédentes, telles que les spectroscopies vibrationnelles (spectroscopie infrarouge à transformée de Fourier et Raman), la spectroscopie d'absorption des rayons X et la diffraction des rayons X est discutée. Différents résultats de mesures par spectroscopie de fluorescence X effectués sur des échantillons biologiques de différentes natures (concrétions, dispositifs médicaux, fluides et tissus biologiques) sont présentés.

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“…These include portable radiography apparatus [96], which can define an area of interest for extraction of biological samples if possible and necessary for subsequent characterization. XRF (for elemental analysis and quantification) [97,98], FTIR [99][100][101][102] or Raman [103][104][105] spectroscopies (to determine the nature and amount of chemical compounds present in the sample) constitute at least three characterization techniques which can be applied in vivo. It is worth mentioning that biological fluids (or actual tissue in the case of accident trauma) can also be analysed, in which case, two other techniques namely X-ray Diffraction (XRD, to determine the nature and quantity of any crystalline phases present in the sample) and tabletop SEM (for submicrometer scale surface imaging) can also be applied.…”

Section: In Vivo Analysis At the Physician's Surgery Or Place Of Injurymentioning

confidence: 99%

Profile of an “at cutting edge” pathology laboratory for pathological human deposits: from nanometer to in vivo scale analysis on large scale facilities

Bazin¹,

Lucas²,

Rouzière³

et al. 2022

Comptes Rendus. Chimie

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In Vivo X-Ray Fluorescence Analysis with Applications to Platinum, Gold and Mercury in Man — Experiments, Improvements, and Patient Measurements

Cited by 18 publications

References 8 publications

Development of XFCT imaging strategy for monitoring the spatial distribution of platinum‐based chemodrugs: Instrumentation and phantom validation

Development of XFCT imaging strategy for monitoring the spatial distribution of platinum‐based chemodrugs: Instrumentation and phantom validation

The crucial contribution of X-ray fluorescence spectroscopy in medicine

Profile of an “at cutting edge” pathology laboratory for pathological human deposits: from nanometer to in vivo scale analysis on large scale facilities

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