In Vivo Verification of an Automatic Noninvasive System for Real Time Kt Evaluation

Steil, H.; Kaufman, Allen; Morris, Alice T.; Levin, Nathan W.; Polaschegg, Hans D.

doi:10.1097/00002480-199307000-00040

Cited by 6 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By indirect estimation of Na + concentrations in the dialysate from the conductivity at the inlet and outlet of the dialyzer, it is possible to determine its diffusion profile and calculate its EID. Thus, EID of Na + is used to calculate the “diffusibility” of urea through the membrane and the determination of the urea clearance . For measurement of Na + EID, conductivity sensor cells are installed in the inlet and outlet lines that carry dialysate to and from the dialyzer.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Online measurement of hemodialysis adequacy using effective ionic dialysance of sodium—a review of its principles, applications, benefits, and risks

Aslam

Saggi

Salifu

et al. 2017

Hemodialysis International

View full text Add to dashboard Cite

Dialysis dose is an important determinant of clinical outcomes in patients with end stage renal disease on maintenance dialysis. In clinical practice dialysis dose is monitored at least monthly by urea clearance based on Urea Kinetic Modeling. Online clearance monitoring using effective ionic dialysance (EID) of sodium (Na 1 ) is available on some hemodialysis machines. This paper reviews the background, methodology, additional applications, and potential risks associated with EID. Effective ionic dialysance provides a reliable, real-time, noninvasive, and inexpensive measurement of dialysis dose during an ongoing hemodialysis (HD) session to allow interventions and assess the impact of these changes on clearance. Surveillance of vascular access flow rates can be used to screen for access dysfunction and refer for interventions. There is a concern that EID measurements may cause Na 1 loading because of high dialysate Na 1 used during these measurements, however, mathematical models, in vitro experiments, and clinical studies in patients on maintenance HD do not show any evidence of Na 1 loading during EID measurements. We cannot rule out the possibility of nonosmotic Na 1 accumulation in the skin because no published literature exists on this topic as it pertains to clearance measurements based on EID of Na 1 .

show abstract

Section: Introductionmentioning

confidence: 99%

“…Steil et al demonstrated that the Na + EID is directly proportional to urea clearance in vitro and in 6 patients on MHD with a correlation of 0.998 between blood side urea clearance and K ecn in the in vitro experiments . Kuhlmann et al compared the results with conventional urea clearance‐based values in 20 MHD patients.…”

Section: Introductionmentioning

confidence: 99%

Online measurement of hemodialysis adequacy using effective ionic dialysance of sodium—a review of its principles, applications, benefits, and risks

Aslam

Saggi

Salifu

et al. 2017

Hemodialysis International

View full text Add to dashboard Cite

show abstract

On-line dialyser clearance using conductivity

Polaschegg

1995

Pediatr Nephrol

View full text Add to dashboard Cite

A method allowing non-invasive measurement of dialyser clearance in vivo is described. Electrolyte concentration difference is measured by two conductivity sensors positioned up- and downstream of the dialyser in the dialysate path. From the conductivity differences measured at two different dialysate input concentrations and dialysate flow, electrolyte dialysance is calculated. The method takes recirculation effects into account and measures effective clearance rather than dialyser clearance. Test results comparing on-line electrolyte clearance with blood side clearance corrected for recirculation are consistent with this calculation. From clearance measured several times during dialysis and time on dialysis, K.t can be calculated with an estimated accuracy of +/- 10%. This method can be used to control the efficacy of each individual treatment. The K.t goal can be derived from monthly two-pool kinetic modelling.

show abstract