In vivo validation of a new portable stimulator for chronic deep brain stimulation in freely moving rats

Tibar, Houyam; Naudet, Frédéric; Kolbl, Florian; Ribot, Bastien; Faggiani, Emilie; N’Kaoua, Gilles; Renaud, Sylvie; Lewis, Noëlle; Benazzouz, Abdelhamid

doi:10.1016/j.jneumeth.2019.108577

Cited by 7 publications

(5 citation statements)

References 28 publications

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“…Table 5 compares the features of the neurostimulator circuit with a few related key works found in the literature [33][34][35][36][37][38][39]. All the works listed in Table 5 were implemented using CMOS components.…”

Section: Discussionmentioning

confidence: 99%

A Microdevice in a Submicron CMOS for Closed-Loop Deep-Brain Stimulation (CLDBS)

Nordi,

Gounella,

Amorim

et al. 2024

JLPEA

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Deep-brain stimulation (DBS) is a highly effective and safe medical treatment that improves the lives of patients with a wide range of neurological and psychiatric diseases. It has been established as a first-line tool in the treatment of these conditions for the past two decades. Closed-loop deep-brain stimulation (CLDBS) advances this tool further by automatically adjusting the stimulation parameters in real time based on the brain’s response. In this context, this paper presents a low-noise amplifier (LNA) and a neurostimulator circuit fabricated using the low-power/low-voltage 65 nm CMOS process from TSMC. The circuits are specifically designed for implantable applications. To achieve the best tradeoff between input-referred noise and power consumption, metaheuristic algorithms were employed to determine and optimize the dimensions of the LNA devices during the design phase. Measurement results showed that the LNA had a gain of 41.2 dB; a 3 dB bandwidth spanning over three decades, from 1.5 Hz to 11.5 kHz; a power consumption of 5.9 µW; and an input-referred noise of 3.45 µVRMS, from 200 Hz to 11.5 kHz. The neurostimulator circuit is a programmable Howland current pump. Measurements have shown its capability to generate currents with arbitrary shapes and ranging from −325 µA to +318 µA. Simulations indicated a quiescent power consumption of 0.13 µW, with zero neurostimulation current. Both the LNA and the neurostimulator circuits are supplied with a 1.2 V voltage and occupy a microdevice area of 145 µm × 311 µm and 88 µm × 89 µm, respectively, making them suitable for implantation in applications involving closed-loop deep-brain stimulation.

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Section: Discussionmentioning

confidence: 99%

A Microdevice in a Submicron CMOS for Closed-Loop Deep-Brain Stimulation (CLDBS)

Nordi,

Gounella,

Amorim

et al. 2024

JLPEA

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“…The instrument's ability to perform the analysis of bio-impedance was tested. The impedance of four different implantable electrodes designed for neural stimulation was measured: a CUFF electrode (NC-2.5-3-125umSS, MicroProbes, USA), a custom LIFE electrode [43], a TIME electrode (Neural Probe, Neuronexus, USA) and a custom deep-brain stimulation (DBS) electrode [44].…”

Section: Impedance Spectroscopy On Implantable Electrodesmentioning

confidence: 99%

“…Here we demonstrate the feasibility of EIS on an isolated ex-vivo calf brain implanted with DBS electrodes. A custom DBS electrode [44] was inserted in the left frontal lobe and the impedance was evaluated from 10 Hz to 10 MHz using a potentiostatic measurement, with a measurement signal of 100 mV. At t ¼ 0; the brain was placed inside a tank half-filled with a saline solution with a conductivity of about 2 S/m.…”

Section: Monitoring Eis On An Ex-vivo Calf Brainmentioning

confidence: 99%

BIMMS: A versatile and portable system for biological tissue and electrode-tissue interface electrical characterization

Regnacq¹,

Bornat²,

Romain³

et al. 2023

HardwareX

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“…Wireless telemetry systems and cranial implants in rodents for neural recording, stimulation, optogenetics, intra-cranial catheterisation and combinations thereof are increasingly used in experimental protocols in neuroscience. These systems typically consist of a cranial implant embedded in dental acrylic cement, held in place by bone screws, with a neurostimulator or amplifier in the form of a headstage, 1 rucksack 2 or implant under the skin, 3 temporarily or continuously attached.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of pair-housing of rats after cranial implant surgery

2022

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Rat models employing cranial implants are increasingly employed to facilitate neural stimulation and recording in freely moving animals. Due to possible damage to wound, implant or attached devices, rats with cranial implants are traditionally housed singly, and little information is available on group- or pair-housing. Here we describe a protocol for pair-housing rats following cranial implant surgery and describe our experience with pair-housing during post-surgical recovery and up to 16 weeks following surgery. Thirty-six adult Wistar rats of both sexes were implanted with deep brain stimulation electrodes. Ten rats were equipped with an additional wireless headstage. Rats were housed in stable pairs before surgery and re-introduced 0–18 h post-surgery. Rat grimace scores did not indicate pain after conclusion of the analgesia protocol, physiological parameters were in the normal range three days post-surgery and weight loss did not exceed 10%. Rats with a cement cap only were pair-housed continuously without damage to the headcap. Rats carrying an additional fragile headstage had to be separated during lights-off periods to prevent headstage damage but could be pair-housed during lights-on periods. Pair-housing is a feasible and effective method to facilitate the rats’ need for social companionship following cranial implant surgery.

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In vivo validation of a new portable stimulator for chronic deep brain stimulation in freely moving rats

Cited by 7 publications

References 28 publications

A Microdevice in a Submicron CMOS for Closed-Loop Deep-Brain Stimulation (CLDBS)

A Microdevice in a Submicron CMOS for Closed-Loop Deep-Brain Stimulation (CLDBS)

BIMMS: A versatile and portable system for biological tissue and electrode-tissue interface electrical characterization

Feasibility of pair-housing of rats after cranial implant surgery

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