In Vivo Ultrasound Imaging of Thrombi Using a Target-Specific Contrast Agent

Tardy, Isabelle; Pochon, Sibylle; Theraulaz, Martine; Nanjappan, P.; Schneider, Michel

doi:10.1016/s1076-6332(03)80207-6

Cited by 24 publications

(7 citation statements)

References 7 publications

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“…Moreover, lipid-based perfluorobutane-filled microbubbles have been synthesized with various densities of anti-intercellular adhesion molecule-1 monoclonal antibodies conjugated to the bubble shell to investigate early stages of atherosclerosis [13]. Targeted microbubbles directed to the GPIIb/IIIa receptor of activated platelets have also been developed for the visualization of the thrombus [14, 15], and leukocyte-targeted microbubbles can be used to characterize inflammation [16] and identify inflamed plaques [17]. Targeted microbubbles, using a combination of echocardiography, carotid US and transcranial duplex US, may provide us with information not only about clot composition, but also the potential source of emboli [97].…”

Section: Molecular Imaging With Us In Cerebral Ischemiamentioning

confidence: 99%

“…US techniques are particularly useful to monitor arterial recanalization with tissue plasminogen activator (tPA) administration in acute stroke. Moreover, recent research has demonstrated the potential of transcranial color-coded sonography (TCCS) with microbubble contrast agents to assess brain perfusion [10, 11] and to identify regions of angiogenesis, inflammation and thrombus [12,13,14,15,16,17]. …”

Section: Introductionmentioning

confidence: 99%

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Update on Ultrasound Techniques for the Diagnosis of Cerebral Ischemia

Martínez-Sánchez

Serena²,

Alexandrov³

et al. 2009

Cerebrovasc Dis

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Ultrasound (US) techniques increase the ability of neurologists specializing in stroke to rapidly evaluate stroke patients, determine likely mechanisms of brain ischemia, determine arterial patency, quantify stenosis severity, and determine the most appropriate clinical management. Furthermore, the development of new US techniques based on the detection of US contrast agents may permit the evaluation of cerebral microcirculation and the identification of regions of angiogenesis, inflammation and thrombus during brain ischemia.

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Section: Molecular Imaging With Us In Cerebral Ischemiamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Update on Ultrasound Techniques for the Diagnosis of Cerebral Ischemia

Martínez-Sánchez

Serena²,

Alexandrov³

et al. 2009

Cerebrovasc Dis

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“…Many articles have already been published on the attachment of microbubbles on targets such as thrombi, [73][74][75][76][77][78] intercellular adhesion molecule 1, 76,[79][80][81] or P-selectin 82,83 via direct injection of targeted bubbles [75][76][77][78][79]81,82 or multiplestep regimens (eg, injection of biotin antibodies followed by avidin and microbubbles). 73,74,78 This topic of research is not only academic but also pursued in private companies.…”

Section: Targeted Microbubblesmentioning

confidence: 99%

Ultrasound Contrast Agents for Brain Perfusion Imaging and Ischemic Stroke Therapy

Martina

Meyer‐Wiethe

Allémann

et al. 2005

Journal of Neuroimaging

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Stroke is one of the major causes of death and disabilities in industrialized countries. Ultrasound imaging is a largely wide spread bedside technique that is easily accessible and valuable in case of emergency but suffers from the fact that the ultrasound wave has to cross the skull for brain imaging. However, ultrasound contrast agents and new contrast-specific imaging modalities have helped to improve the diagnostic quality of transcranial ultrasonography. This review article surveys and discusses the current state of microbubbles technology and the use of contrast-enhanced transcranial ultrasound for the assessment of brain perfusion. Future aspects and expectations in contrast agent functionality, such as targeting and drug or gene delivery, acceleration of thrombolysis, and imaging technology, are also discussed.

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“…Successful applications of target-specific microbubbles for preclinical imaging of inflammation-and angiogenesis-associated molecular markers are found in the literature. 1,2 Angiogenesis is the growth of new capillary blood vessels from pre-existing vessels. This process is crucial during development, reproduction, and wound healing.…”

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confidence: 99%