In vivo tumor targeting of tumor necrosis factor-α-loaded stealth nanoparticles: Effect of MePEG molecular weight and particle size

Fang, Chao; Shi, Bin; Pei, Yuanying; Hong, Minghuang; Wu, Jiang; Chen, Hongzhuan

doi:10.1016/j.ejps.2005.08.002

Cited by 393 publications

(218 citation statements)

References 19 publications

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“…This is typical for assemblies with PEO coronas. 45 On the other hand, all of the phosphonium-functionalized micelles had positive ζ-potentials and these ranged from 19 to 30 mV. This confirms that the phosphonium cations reside on the surface of the micelles.…”

Section: Micelle Preparation and Characterizationsupporting

confidence: 63%

Phosphonium-Functionalized Polymer Micelles with Intrinsic Antibacterial Activity

2017

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New approaches to treat bacterial infections are badly needed to address the increasing problem of antibiotic-resistance. This study explores phosphonium-functionalized block copolymer micelles as intrinsically antibacterial polymer assemblies. Phosphonium cations with varying alkyl lengths were conjugated to the terminus of a poly(ethylene oxide)-polycaprolactone block copolymer and the phosphonium-functionalized block copolymers were self-assembled to form micelles in aqueous solution. The size, morphology, and z-potential of the assemblies were studied and their abilities to kill Escherichia coli and Staphylococcus aureus were evaluated. It was found that the minimum bactericidal concentration depended on the phosphonium alkyl chain length and different trends were observed for Gram-negative and Gram-positive bacteria.The most active assemblies exhibited no hemolysis of red blood cells above the bactericidal 2 concentrations, indicating that they can selectively disrupt the membranes of bacteria.Furthermore, it was possible to encapsulate and release the antibiotic tetracycline using the assemblies, providing a potential multi-mechanistic approach to bacterial killing.

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Section: Micelle Preparation and Characterizationsupporting

confidence: 63%

Phosphonium-Functionalized Polymer Micelles with Intrinsic Antibacterial Activity

2017

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“…It has been indicated that PEGylated nanoparticles smaller than 100 nm have reduced plasma protein adsorption on their surfaces, and the blood clearance of such nanoparticles is slower than for larger (.100 nm) nanoparticles. 31,54 Our results show that the covalent coating of ICG-NCs with 5 kDa PEG can increase the blood circulation time of ICG. Our findings are consistent with reports by Ballou et al 55 and Ohno et al, 56 who have indicated prolonged systemic circulation of PEGylated silica nanoparticles in vivo.…”

mentioning

confidence: 80%

Effects of nanoencapsulation and PEGylation on biodistribution of indocyanine green in healthy mice: quantitative fluorescence imaging and analysis of organs

Bahmani¹,

Lytle²,

Walker³

et al. 2013

IJN

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Near-infrared nanoconstructs present a potentially effective platform for site-specific and deep tissue optical imaging and phototherapy. We have engineered a polymeric nanocapsule composed of polyallylamine hydrochloride (PAH) chains cross-linked with sodium phosphate and doped with indocyanine green (ICG) toward such endeavors. The ICG-doped nanocapsules were coated covalently with polyethylene glycol (5000 daltons) through reductive amination. We administrated the constructs by tail vein injection to healthy mice. To characterize the biodistribution of the constructs, we performed in vivo quantitative fluorescence imaging and subsequently analyzed the various extracted organs. Our results suggest that encapsulation of ICG in these PEGylated constructs is an effective approach to prolong the circulation time of ICG and delay its hepatic accumulation. Increased bioavailability of ICG, due to encapsulation, offers the potential of extending the clinical applications of ICG, which are currently limited due to rapid elimination of ICG from the vasculature. Our results also indicate that PAH and ICG-doped nanocapsules (ICG-NCs) are not cytotoxic at the levels used in this study.

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“…It has been shown that recognition of SPIONs by macrophages and systemic clearance depends on the size of the particles, i.e., smaller particles have slower systemic clearance. 36 Notably, immobilization of SPIONs or labeled cells in the blood flow is a complicated process, which requires an external magnetic field with suitable strength. Practically, to resist Brownian and hydrodynamic forces in the blood flow, the field induction should be ≥1 T, which can be easily achieved using powerful permanent magnets based on neodymium-iron alloys.…”

Section: Discussionmentioning

confidence: 99%

137 Superparamagnetic Iron Oxide Nanoparticle Targeting of Adipose Tissue-Derived Stem Cells in Diabetes-Associated Erectile Dysfunction

Zhu¹

2017

The Journal of Sexual Medicine

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In vivo tumor targeting of tumor necrosis factor-α-loaded stealth nanoparticles: Effect of MePEG molecular weight and particle size

Cited by 393 publications

References 19 publications

Phosphonium-Functionalized Polymer Micelles with Intrinsic Antibacterial Activity

Phosphonium-Functionalized Polymer Micelles with Intrinsic Antibacterial Activity

Effects of nanoencapsulation and PEGylation on biodistribution of indocyanine green in healthy mice: quantitative fluorescence imaging and analysis of organs

137 Superparamagnetic Iron Oxide Nanoparticle Targeting of Adipose Tissue-Derived Stem Cells in Diabetes-Associated Erectile Dysfunction

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