In vivo triglyceride secretion and hepatic and plasma lipids in rats fed medium-chain triglycerides, tripelargonin, or corn oil

Ecelbarger, Gary L.; Lasekan, John B.; Ney, Denise M.

doi:10.1016/0955-2863(91)90085-j

Cited by 18 publications

(12 citation statements)

References 33 publications

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“…6) However, several studies have shown that mediumchain saturated fatty acids lower cholesterol in animals. [7][8][9][10] We have found that when 10 g W day of MCT was given to healthy subjects for 12 weeks, the serum total cholesterol levels did not diŠer signiˆcantly from that of the group that received LCTs. However, little known is about the long-term eŠects of the amount of dietary MCTs on blood lipid levels in healthy subjects.…”

mentioning

confidence: 93%

Effects of Dietary Medium-Chain Triacylglycerols on Serum Lipoproteins and Biochemical Parameters in Healthy Men

Nosaka

Kasai

Nakamura

et al. 2002

Bioscience, Biotechnology, and Biochemistry

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The objective of this study was to investigate eŠects of dietary medium-chain triacylglycerols (MCTs) on serum lipid levels, liver function, and hepatic fat accumulations in healthy men. Eleven subjects consumed 2200-2600 kcal daily, of which 70-80 g was fat; the fat included 40 g of MCTs or else 40 g of long-chain triacylglycerols (blended vegetable oil). The diet was followed for 4 weeks in this controlled double-blind study. At the end of the experiment, signiˆcant diŠerences were not found in the concentrations of serum total cholesterol, very low density lipoprotein cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol between the groups. Serum triglycerol levels were not signiˆcantly diŠerent in the groups. Adverse eŠects from ingestion of MCTs on liver functions, the liver-to-spleen ratio on computed tomography (an index of fatty liver), or results of blood tests were not seen. The results suggest that the long-term eŠects of dietary MCTs on serum cholesterol were similar to those of unsaturated fatty acids found abundantly in vegetable oil, and that consumption of MCTs in the amount of 40 g W day for a month does not cause liver fat accumulation or liver dysfunction.

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confidence: 93%

Effects of Dietary Medium-Chain Triacylglycerols on Serum Lipoproteins and Biochemical Parameters in Healthy Men

Nosaka

Kasai

Nakamura

et al. 2002

Bioscience, Biotechnology, and Biochemistry

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“…On the contrary, by means of histological methods, no specific im pairment of liver morphology could be de tected for the C9TG/LCT group. Further more, in studies feeding ONMCT to rats or pigs, no negative influence of ONMCT on liv er structure was described [14][15][16][17][18][19][20][21][22][23]. It is as sumed that in these studies existing liver changes would have been noted during the preparation for lipid and glycogen analysis.…”

Section: Discussionmentioning

confidence: 99%

“…2) and seems to be true for even-numbered as well as for odd-numbered MCT. Also feeding of ONMCT (C9TG) to rats resulted in lower triglyceride concentra tions of the liver when compared to LCT administration [14], Regarding organ masses, the C9TG/LCT emulsion revealed no inferiority in compari son with the other fat emulsions tested ( fig. 1).…”

Section: Discussionmentioning

confidence: 99%

Organ Changes after Intravenous Trinonanoin Administration in Rabbits

Linseisen

Wolfram²

1993

Ann Nutr Metab

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For 11 days, an odd-numbered medium-chain triglyceride (trinonanoin, C₉TG)/long-chain triglyceride (LCT) emulsion was given parenterally to rabbits, providing 46.5% of total energy. In comparison with LCT or MCT/LCT fat emulsions, no negative effects on organ weights and liver lipid concentrations were noted. In some rabbits of the C₉TG/LCT group macroscopically but not histologically visible liver changes were observed. The extent of nonanoic acid deposition in liver triglycerides, liver phospholipids, adipose tissue and skeletal muscle after C₉TG/LCT administration was similar to C₈/C₁₀ deposition in the MCT/LCT group; the enrichment of adipose tissue with 16 mol% was higher than expected.

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“…Since then, they have been widely studied. Although a large number of excellent reports have been published, most of these focus on clinical nutritional or biochemical standpoints (Seaton et al, 1986;Lavau and Hashim, 1978;Gelebter et al, 1983;Chanez et al, 1991;Kris-Etherton and Yu, 1997;Kritchevsky and Tepper, 1965;Leveilie et al, 1967;Ecelbarger et al, 1991;Papamandjaris et al, 1998). In contrast, very few studies have been conducted from a food science standpoint.…”

Section: Introductionmentioning

confidence: 99%

Rheological properties and oxidative stability during storage of dough fried made from corn oil with medium-chain triacylglycerols (MCT)

Toyosaki¹

2014

Afr. J. Food Sci.

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The rheological properties, oxidative stability, and water contents of the fried dough made from corn oil with medium-chain triacylglycerols (MCT), which is a mixture of MCT and corn oil at a volume ratio of 0% (0:100), 10% (10:90), 20% (20:80) and 30% (30:70) were studied. Flour dough was fried at 140°C for 6 min in fried dough and stored in a glass bottle at 50°C in the dark for 20 days. The water contents and the decreasing rate with storage time were lower in fried dough in corn oil containing MCT than in fried dough in 100% corn oil. The concentration of hydroperoxides in fried dough increased slightly for 8 days storage and increased rapidly thereafter. The concentration of hydroperoxides and the increasing rate with storage time were lower in fried dough in corn oil containing MCT than in fried dough in 100% corn oil. The hardness decreased slightly with 20 and 30% MCT oils for 20 days. In contrast, 0 and 10% MCT oils significantly increased the hardness. Adhesion of fried dough was slight with 20 and 30% MCT oil fried dough. From these results, it is a very high functional property to deep-fry dough that has been clarified with MCT.

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In vivo triglyceride secretion and hepatic and plasma lipids in rats fed medium-chain triglycerides, tripelargonin, or corn oil

Cited by 18 publications

References 33 publications

Effects of Dietary Medium-Chain Triacylglycerols on Serum Lipoproteins and Biochemical Parameters in Healthy Men

Effects of Dietary Medium-Chain Triacylglycerols on Serum Lipoproteins and Biochemical Parameters in Healthy Men

Organ Changes after Intravenous Trinonanoin Administration in Rabbits

Rheological properties and oxidative stability during storage of dough fried made from corn oil with medium-chain triacylglycerols (MCT)

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