In vivo tretinoin-induced changes in skin mechanical properties

Berardesca, Enzo; Gabba, P.; Farinelli, Nadia; Borroni, G.; Rabbiosi, G.

doi:10.1111/j.1365-2133.1990.tb14729.x

Cited by 40 publications

(20 citation statements)

References 12 publications

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“…An improvement of skin elasticity was recorded after 4 months of treatment, whereas skin extensibility was unchanged [23], confirming the rele vance of skin elasticity in monitoring aging. Data were obtained using forces involving collagen fibers in the responses: collagen synthesis has been reported to increase after topical tretinoin treatment [24]; no effect was detectable on elastic fibers.…”

Section: Mechanical Propertiessupporting

confidence: 60%

Skin Bioengineering in the Noninvasive Assessment of Cutaneous Aging

et al. 1991

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Cutaneous changes induced by aging can be quantified and monitored noninvasively by means of bioengineering tools. Skin elasticity, hydration, skin blood flow and skin surface pattern show age-related changes reflecting the damage of cutaneous structures involved. Impairment and degeneration of elastic and collagen networks are responsible for the progressive decrease in skin elasticity recorded during aging. Reduction in blood flow and water supply with probably defective stratum corneum binding result in reduced stratum corneum water content and transepidermal water loss. Morphological changes such as increased skin roughness pigmentation and alteration of skin surface pattern appearing from the age of 30 years onwards may be investigated at a subclinical level allowing the detection of early signs of aging.

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Section: Mechanical Propertiessupporting

confidence: 60%

Skin Bioengineering in the Noninvasive Assessment of Cutaneous Aging

et al. 1991

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“…25 It is thought that the increased collagen content indirectly stimulates normalization of the elastic tissue organization. 26 Increased smoothness of skin or wrinkle effacement from tretinoin topical treatment results from epidermal hyperplasia, compaction of the stratum corneum, thickening of the granular layer, and increased epidermal and dermal glycosaminoglycan deposition. Tretinoin therapy has also been shown to improve wound healing.…”

Section: Histologic Retinoid Effectsmentioning

confidence: 99%

Reversal of Skin Aging with Topical Retinoids

Hubbard

Unger²,

Rohrich

2014

Plastic &Amp; Reconstructive Surgery

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Topical skin care and its place in plastic surgery today are often overlooked by clinicians formulating a plan for facial rejuvenation. Not only is it important to consider topical skin care as part of comprehensive care, but clinicians should also be educated with the data available in today's literature. This review aims to familiarize the reader with the biological processes of skin aging and evidence-based clinical outcomes afforded by various topical therapies. Furthermore, this review will focus on solar damage, the value of retinoids, and how they can be used in conjunction with forms of treatment such as chemical peel, dermabrasion, and lasers. Finally, guidelines will be provided to help the physician administer appropriate skin care based on the data presented.

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“…32 The benefit is attributed to an increase in elasticity with dermal collagen deposition and alignment. 33 One of the more popular choices for medical therapy, again, mostly for hypertrophic scars and keloids, is the use of the generically termed ''steroids.'' These are substances that are based on 4 fused carbon rings that derive from the cholesterol molecule.…”

Section: Medical Managementmentioning

confidence: 99%