In vivo tracking of 111In-oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis

Gholamrezanezhad, Ali; Mirpour, Sahar; Bagheri, Mohammad; Mohamadnejad, Mehdi; Alimoghaddam, Kamran; Abdolahzadeh, Leila; Saghari, Mohsen; Malekzadeh, Reza

doi:10.1016/j.nucmedbio.2011.03.008

Cited by 212 publications

(179 citation statements)

References 25 publications

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“…Intravenously infused cells first reach the lungs and then redistribute to the liver and spleen, 16 whereas there is little proof of specific homing to inflamed tissue. 9 Autopsy examinations have revealed that BM-MSCs can be detected in the lungs and lymph nodes of some patients, but at low levels.…”

Section: Introductionmentioning

confidence: 99%

Stromal cells–are they really useful for GVHD?

Kaipe

Erkers

Sadeghi

et al. 2014

Bone Marrow Transplant

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Mesenchymal stromal cells (MSCs) have immunomodulatory effects and are increasingly being used for the treatment of acute and chronic GVHD. Although they seem immuno-privileged, they induce alloresponses, but the risk of immunization is poorly characterized. After infusion, they first reach the lungs, liver and spleen, and are then difficult to trace. Several mechanisms are involved in stromal cells suppressing alloreactivity, such as induction of regulatory T cells, but whether or not this will also affect leukemic relapse or increase infections is not known. Although several encouraging pilot studies have been published, there have been few prospective randomized trials. There may be a bias in the literature, as negative results are seldom published, and there have been few comparative studies with other immunosuppressive regimens. Most animal models have failed to show any effect on GVHD. Several questions remain to be answered for optimization of stromal cell therapy. Which source is optimal-BM, fat, cord or decidua? Can stromal cells be replaced by exosomes, which culture conditions are most appropriate and at what passage and how frequently should cells be administered? More research is required to move stromal cell therapy forward to become an established treatment for acute and chronic GVHD.

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Section: Introductionmentioning

confidence: 99%

Stromal cells–are they really useful for GVHD?

Kaipe

Erkers

Sadeghi

et al. 2014

Bone Marrow Transplant

View full text Add to dashboard Cite

show abstract

“…Hence, the radiotracer seems to be suitable for clinical imaging, regarding its in vivo stability. In our experience in patients with liver cirrhosis, we found no unexpected adverse events or complications during labeled stem cell infusion and within one month follow up period (Gholamrezanezhad, Mirpour et al 2011). The cells can be visualized in vivo up to at least 10 days after initial infusion and it is possible to quantify and follow them using radio-labeling with 111 Indium derivatives (Gholamrezanezhad, Mirpour et al 2011).…”

Section: -Spect (Single Photon Emission Computed Tomography)mentioning

confidence: 56%

“…In our experience in patients with liver cirrhosis, we found no unexpected adverse events or complications during labeled stem cell infusion and within one month follow up period (Gholamrezanezhad, Mirpour et al 2011). The cells can be visualized in vivo up to at least 10 days after initial infusion and it is possible to quantify and follow them using radio-labeling with 111 Indium derivatives (Gholamrezanezhad, Mirpour et al 2011). The main problem with application of 111 Indium-labed chemicals for stem cell tracking is the concern about its cytotoxic effects on stem cells which will adversely affect their possible therapeutic potential for patients.…”

Section: -Spect (Single Photon Emission Computed Tomography)mentioning

confidence: 56%

“…111 In-oxine: Indium-111 is an Auger electron emitter, which internalizes nonspecifically into both normal and malignant cells Gholamrezanezhad, Mirpour et al 2009). Thanks to the long half life of Indium-111, serial tracking of cells over 10 days using single photo electron computed tomography (SPECT) imaging is possible (Gholamrezanezhad, Mirpour et al 2011). Given that Indium-111 oxine was approved for clinical application for labeling white blood cells to track sites of inflammation since more than 20 years ago (Lavender, Goldman et al 1977;, it was an acceptable extension to label stem cells for noninvasive tracking of cells in human biodistribution studies (Lavender, Goldman et al 1977;Gao, Dennis et al 2001;Aicher, Brenner et al 2003;Barkholt, Danielsson et al 2003;Chin, Nakamoto et al 2003;Barkholt, Danielsson et al 2004;Brenner, Aicher et al 2004;Maskali, Tran et al 2004;Maskali, Tran et al 2005;Legrand, Cougnenc et al 2007).…”

Section: -Spect (Single Photon Emission Computed Tomography)mentioning

confidence: 99%

“…The field of stem cell biology and regenerative medicine is rapidly moving toward translation to clinical application (Gholamrezanezhad, Bagheri et al 2007;Gholamrezanezhad, Mirpour et al 2011). Stem cells are able to perform restorative functions in patients with different disorders and hence stem cell therapy may be a potential alternative to some of the current modalities of treatment, such as organ transplantation.…”

Section: Introductionmentioning

confidence: 99%

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