In vivo toxicological effects and spectral studies of organotin(IV)N-maleoylglycinates

Spectral analysis andin vitrocytotoxicity profiles of novel organotin(IV) esters of 2-maleimidopropanoic acid

“…The title complexes followed a fragmentation pattern as earlier reported [19,23]. The base peak for 1, 4 and 5 was due to the [LSnR 2 ] þ fragment at m/z 317, 401, 441, respectively; while in 2, 3 and 6 the [LBSnR] þ fragment was at m/z 318, 330 and 378 [36].…”

“…It is reported in the literature that Dn values . 200 and , 350 cm 21 reflected the bidentate coordination in chain structures formed by bridging carboxylate groups for 1 -6 ( Figure 1a) [19,21]. Moreover, a characteristic sharp peak at 450 cm 21 was seen in the spectrum of 5 which also confirmed the SnZPh linkage (Table II) [29].…”

In vivo toxicological effects and spectral studies of new triorganotin(IV)–N-maleoyltranexamates

“…Characteristic vibrational frequencies have been identified by comparing the spectra of all the complexes with their precursors [9,[11][12][13][14]. The data are consistent with the formation of well-defined complexes with the composition R 0 3 SnR, which was confirmed by the presence of Sn-O and Sn-C bonds in the range 516-543 cm À1 and 525-542 cm À1 , respectively [22][23][24].…”

“…Organotin(IV) esters of carboxylic acids are widely studied due their potential as anti-tumour agents, though, the cause of this activity is still a question to be answered [5][6][7][8][9][10]. Amino acids and their derivatives are therapeutic molecules and interesting ligands in the coordination chemistry of organotin(IV) carboxylates [11][12][13][14][15][16][17][18][19][20]. In order to develop new organotin biocides with bio-active ligands; we have synthesized, characterized and tested the in vitro as well as in vivo anti-tumour activity of five new triorganotin(IV) complexes of therapeutic molecule like tranexamic acid (Fig.…”

Antiproliferative and anti-tumor activity of organotin compounds

“…In vivo anti-tumor effects of a series of organotin(IV) derivatives of N-maleoylglycine (HL) (Scheme 2A, X = H) of formulae R 2 Sn(L) 2 (78-80) or R 3 SnL (R = methyl, n-butyl and benzyl group) (81-83) were also reported [39]. In vivo toxicity profiles in mice and anti-tumor activities in tumor-bearing (colon 26A) mice were obtained for the title organotin(IV) carboxylates 78-83.…”