In vivo toxicity and immunogenicity of wheat germ agglutinin conjugated poly(ethylene glycol)-poly(lactic acid) nanoparticles for intranasal delivery to the brain

Li, Qingfeng; Shao, Xia; Chen, Jie; Shen, Yehong; Chen, Feng; Gao, Xiaoling; Zhao, Yue; Li, Jingwei; Zhang, Qizhi; Jiang, Xinguo

doi:10.1016/j.taap.2010.12.003

Cited by 49 publications

(9 citation statements)

References 40 publications

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“…However, the brain targeting delivery of these polymer-based nanoparticles is still limited. Liu et al evaluated the in vivo toxicity and immunogenicity of poly(ethylene glycol)-poly(lactic acid) (PEG-PLA) NP conjugated to WGA after repeated intranasal administration [324]. These NP induced slight oxidative stress and excitotoxicity, a process by which nerve cells are damaged by excessive stimulation by neurotransmitters, as evidenced by increased glutamate levels in rat brain and enhanced LDH activity in the rat olfactory bulb.…”

Section: In Vivo Toxicity Of Nanomaterialsmentioning

confidence: 99%

Diagnostic and Therapeutic Uses of Nanomaterials in the Brain

Garbayo¹,

Mendoza²,

Blanco-Prieto

2014

CMC

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Nanomedicine has recently emerged as an exciting tool able to improve the early diagnosis and treatment of a variety of intractable or age-related brain disorders. The most relevant properties of nanomaterials are that they can be engineered in such a way that they can cross the blood brain barrier, with the final aim of targeting specific cells and molecules and to act as vehicles for drugs. Potentially beneficial properties of nanotherapeutics derived from its unique characteristics include improved efficacy, safety, sensitivity and personalization compared to conventional medicines.In this review, recent advances in available nanostructures and nanomaterials for brain applications will be described. Then, the latest nanotechnological applications for the treatment and diagnosis of neurological disorders, mainly brain tumors and neurodegenerative diseases, will be reviewed. Recent investigations of the neurotoxicity of the nanomaterial both in vitro and in vivo will be summarized. Finally, the ongoing challenges that have to be meet if new nanomedical products are to be put on the market will be discussed and some future directions will be outlined.

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Section: In Vivo Toxicity Of Nanomaterialsmentioning

confidence: 99%

Diagnostic and Therapeutic Uses of Nanomaterials in the Brain

Garbayo¹,

Mendoza²,

Blanco-Prieto

2014

CMC

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“…In a recent report, Liu et al tested the levels of amino acid neurotransmitters (i.e., glutamate (Glu), aspartate (Asp), γ-aminobutyric acid (GABA), taurine (Tau) and glycine (Gly) and cytokines as well as enzyme activities in OB and brain after intranasal administration of wheat germ agglutinin (WGA) conjugated poly(ethylene glycol)-poly(lactic acid) (PEG-PLA) nanoparticles (WGA-NP) [54]. Although WGA-NP had no effect on the amino acid neurotransmitter levels in the rat OB, a slight excitotoxicity was observed, as demonstrated by increased Glu level.…”

Section: New Routes For Cns Delivery Of Therapeutic and Diagnosticmentioning

confidence: 99%

Nanomaterial-mediated CNS delivery of diagnostic and therapeutic agents

Biddlestone-Thorpe

Marchi

Guo

et al. 2012

Advanced Drug Delivery Reviews

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Research into the diagnosis and treatment of central nervous system (CNS) diseases has been enhanced by rapid advances in nanotechnology and an expansion in the library of nanostructured carriers. This review discusses the latest applications of nanomaterials in the CNS with an emphasis on brain tumors. Novel administration routes and transport mechanisms for nanomaterial-mediated CNS delivery of diagnostic and therapeutic agents to bypass or cross the blood brain barrier (BBB) are also discussed. These include temporary disruption of the BBB, use of impregnated polymers (polymer wafers), convection-enhanced delivery (CED), and intranasal delivery. Moreover, an in vitro BBB model capable of mimicking geometrical, cellular and rheological features of the human cerebrovasculature has been developed. This is a useful tool that can be used for screening CNS nanoparticles or therapeutics prior to in vivo and clinical investigation. A discussion of this novel model is included.

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“…Due the capability to bind specifically and reversibly to mono-and oligosaccharides [19], lectins may be used as cancer targeting upon conjugation with nanoparticles [20][21][22][23]. However, the synthesis and applications of lectins conjugated with gold nanoparticles are little explored so far.…”

Section: Introductionmentioning

confidence: 99%