In vivo therapeutic applications of phosphorus dendrimers: state of the art

Mignani, Serge; Shi, Xiangyang; Ceña, Valentı́n; Shcharbin, Dzmitry; Bryszewska, Maria; Majoral, Jean‐Pierre

doi:10.1016/j.drudis.2020.11.034

Cited by 25 publications

(16 citation statements)

References 77 publications

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“…Nanoparticles are becoming increasingly involved in therapeutics as drug and genetic material delivery systems [2,3]. This is due to the fact that they can be synthesized with a high degree of control of the structural parameters, yielding highly monodisperse chemical structures [34]. However, nanoparticles can themselves show therapeutic properties in the absence of other added drugs or genetic material [12].…”

Section: Discussionmentioning

confidence: 99%

Engineered Neutral Phosphorous Dendrimers Protect Mouse Cortical Neurons and Brain Organoids from Excitotoxic Death

Posadas

Romero-Castillo

Ronca

et al. 2022

IJMS

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Nanoparticles are playing an increasing role in biomedical applications. Excitotoxicity plays a significant role in the pathophysiology of neurodegenerative diseases, such as Alzheimer’s or Parkinson’s disease. Glutamate ionotropic receptors, mainly those activated by N-methyl-D-aspartate (NMDA), play a key role in excitotoxic death by increasing intraneuronal calcium levels; triggering mitochondrial potential collapse; increasing free radicals; activating caspases 3, 9, and 12; and inducing endoplasmic reticulum stress. Neutral phosphorous dendrimers, acting intracellularly, have neuroprotective actions by interfering with NMDA-mediated excitotoxic mechanisms in rat cortical neurons. In addition, phosphorous dendrimers can access neurons inside human brain organoids, complex tridimensional structures that replicate a significant number of properties of the human brain, to interfere with NMDA-induced mechanisms of neuronal death. Phosphorous dendrimers are one of the few nanoparticles able to gain access to the inside of neurons, both in primary cultures and in brain organoids, and to exert pharmacological actions by themselves.

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Section: Discussionmentioning

confidence: 99%

Engineered Neutral Phosphorous Dendrimers Protect Mouse Cortical Neurons and Brain Organoids from Excitotoxic Death

Posadas

Romero-Castillo

Ronca

et al. 2022

IJMS

Self Cite

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“…This philosophy joins that of the famous painter Henri Matisse (1869–1954), who said ‘C’est l’imagination qui donne au tableau espace et profondeur (‘It is the imagination that gives the painting space and depth’) [ 47 ]. The versatility of phosphorus dendrimers and dendrons as drugs themselves has revealed fascinating properties in different therapeutic fields in nanomedicine [ 48 ]. Collectively, the major advantages of phosphorus dendrimers and dendrons, for instance, in comparison with the widely known PAMAM dendrimers, include: easily tunable surface synthesis, allowing the development of phosphorus dendrimers and dendrons as active drugs per se; higher lot-to-lot chemical stability, mainly for the low generations (G0, G1); good manufacturing practices for clinical use, mainly for the low generations (G0, G1); and several routes of administration.…”

Section: Discussionmentioning

confidence: 99%

First-in-Class Phosphorus Dendritic Framework, a Wide Surface Functional Group Palette Bringing Noteworthy Anti-Cancer and Anti-Tuberculosis Activities: What Lessons to Learn?

et al. 2021

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Based on phenotypic screening, the major advantages of phosphorus dendrimers and dendrons as drugs allowed the discovery of new therapeutic applications, for instance, as anti-cancer and anti-tuberculosis agents. These biological activities depend on the nature of the chemical groups (neutral or cationic) on their surface as well as their generation. As lessons to learn, in the oncology domain, the increase in the generation of metallo-dendrimers is in the same direction as the anti-proliferative activities, in contrast to the development of polycationic dendrimers, where the most potent anti-tuberculosis phosphorus dendrimer was observed to have the lowest generation (G0). The examples presented in this original analysis of phosphorus dendrimers and dendrons provide support for the lessons learned and for the development of new nanoparticles in nanomedicine.

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“…Comparatively, it has been reported that cationic phosphorus dendrimers have better delivery efficiency of siRNA than PAMAM dendrimers 173 . Further, these dendrimers themselves could possess a potent anti-inflammatory action 174 . A previous study conducted by Bohr et al 98 inspected the potential of TNF- α siRNA cationic phosphorus dendrimers to modulate LPS-induced ALI both in vitro and in vivo .…”

Section: Sirna Delivery Systems For Treatment Of Ali/ardsmentioning

confidence: 99%

Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome

Zoulikha

Xiao

Boafo

et al. 2022

Acta Pharmaceutica Sinica B

144

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The use of small interfering RNAs (siRNAs) has been under investigation for the treatment of several unmet medical needs, including acute lung injury/acute respiratory distress syndrome (ALI/ARDS) wherein siRNA may be implemented to modify the expression of pro-inflammatory cytokines and chemokines at the mRNA level. The clear anatomy, accessibility, and relatively low enzyme activity make the lung a good target for local siRNA therapy. However, the clinical translation of siRNA is hampered by the inefficient delivery of siRNA therapeutics to the target cells due to the properties of naked siRNA. Thus, this review will focus on the various delivery systems that can be used and the different barriers that need to be surmounted for the development of stable inhalable siRNA formulations for human use before siRNA therapeutics for ALI/ARDS become available in the clinic.

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In vivo therapeutic applications of phosphorus dendrimers: state of the art

Cited by 25 publications

References 77 publications

Engineered Neutral Phosphorous Dendrimers Protect Mouse Cortical Neurons and Brain Organoids from Excitotoxic Death

Engineered Neutral Phosphorous Dendrimers Protect Mouse Cortical Neurons and Brain Organoids from Excitotoxic Death

First-in-Class Phosphorus Dendritic Framework, a Wide Surface Functional Group Palette Bringing Noteworthy Anti-Cancer and Anti-Tuberculosis Activities: What Lessons to Learn?

Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome

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