In vivo tests of natural therapy, Tibetan yogurt or fresh broccoli, for Helicobacter pylori infection

Abstract

Plants and probiotics have a long history in the treatment of gastrointestinal ailments. Our aim was to evaluate the effectiveness of Tibetan yogurt and fresh broccoli tips in Helicobacter pylori- (H. pylori) infected volunteers, using the urea breath test (UBT) to assess the effect on H. pylori. Clinical trials consisted of ingestion of approximately 135 g of fresh, finely minced juvenile broccoli tips (var. Emperor) in commercial plain yogurt t.i.d, for ten servings (3.3 days) or ingestion of freshly made Tibetan yogurt whey (120 ml) given twice a day for 3.5 days. Urea breath testing was done before and after the natural therapies. Five volunteers received broccoli tips and seven received Tibetan yogurt. No trend for a beneficial effect was seen; the UBT results (delta over baseline) before and after yogurt (35.5+/-12.8 vs. 40.7+/-12.2) (p=0.76) or broccoli (15.8 vs. 19.4) (p=1.0) were unchanged. Antimicrobial end products derived from Tibetan yogurt or broccoli tips have little or no anti-H. pylori effect in vivo. It appears that the gastric mucosal microenvironment apparently shielded H. pylori. In vitro studies suggesting anti-H. pylori activity of compounds should be considered as hypotheses to be tested.

Effect of fermented milk-based probiotic preparations on Helicobacter pylori eradication: a systematic review and meta-analysis of randomized-controlled trials

“…These articles were screened for relevance and fulfillment of selection criteria. Of the 31 potentially relevant clinical trials, 21 were excluded [12,[31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] as specified in Fig. 1 (interrater agreement for eligibility k = 0.946).…”

Meta‐analysis: efficacy of bovine lactoferrin in Helicobacter pylori eradication

“…Many antimicrobial substances have been studied for their usefulness in eradicating H. pylori infection, either as a single agent or as a complementary therapy 5, 6 . One such novel therapy is bovine lactoferrin (bLF) (glycoprotein).…”

In Vitro Activity of Olive Oil Polyphenols against Helicobacter pylori

“…However, in vivo studies with garlic (19), jalapeño peppers (20), cinnamon extract (21), broccoli (22), and cranberry juice (23) failed to eradicate H. pylori infection in spite of the wellreported antibacterial data obtained from in vitro experiments. With this concern in mind, researchers have recommended the consumption of these natural foods as chemopreventive agents (6) or in combination with antibiotics to eradicate the bacterial infection (24).…”