In-vivo Test Procedure and Instrument Characterization for EIS-Based Diagnosis of Prosthesis Osseointegration

Abstract

A method based on Electrochemical Impedance Spectroscopy (EIS) for the diagnosis ofprosthesis osseointegration was proposed by the Authors. In this paper, the in-vivo test procedure, the metrological characterization of a PC-based instrument, and the preliminary experimental results for in-vivo validation are presented. The in-vivo results show the method effectiveness in discriminating different osseointegration levels of percutaneous cochlear prostheses.

EIS measurements for characterization of muscular tissue by means of equivalent electrical parameters

“…The prototyped proof demonstrator, based on a batterypowered notebook PC implemented with an AD/DA board and an analog interface, has been described elsewhere [7,16,17]. It was used, in a clinical tool, for EIS measurements of transcutaneous implants during the osseointegration process [17] and for a preliminary evaluation of muscle tissue [11,16].…”

“…It was used, in a clinical tool, for EIS measurements of transcutaneous implants during the osseointegration process [17] and for a preliminary evaluation of muscle tissue [11,16].…”

Monitoring of Fixture Osteointegration after BAHA® Implantation

“…The selected frequency range is 0.1-10 kHz, as determined by preliminary in vivo experiments [Arpaia et al, 2007b]. In particular, the lower limit avoids the involvement of frequencies that show poor performance of electrodes due to electrical noise [Songer et al, 2001]; the upper limit, even if due to the capability of the proof demonstrator, assures a frequency range in which different bone prosthesis contact surfaces can be evidenced [Arpaia et al, 2007a].…”

“…The maximal electrical current admitted to flow through a living biological tissue [IEC, 2005] limits the stimulus to 320 mV. In practical experience, a stimulus amplitude of 80-100 mV provides adequate noise rejection [Arpaia et al, 2007b]. The values of the modulus, phase, real part and imaginary part of the computed impedance were recorded over the selected frequency range and stored.…”

“…This study was performed in order to put in evidence IZI variations in the target frequency range (0.1-10 kHz) during the different phases of osteointegration. The plot trend along the plane brought information on the state of fixture/bone interface [Arpaia et al, 2007b].…”