In Vivo Techniques for the Study of Gastrointestinal Motility

Corazziari, Enrico

doi:10.1007/978-3-642-68437-1_7

Cited by 3 publications

(2 citation statements)

References 82 publications

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“…Particulate radiopaque markers are a useful method to quantitatively measure the transit time 21 . Total gastrointestinal transit time is measured by taking radiographs of feces for several days after a single administration of markers 21,22 . The method we used has been used by others in ponies and horses 19,23–26 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Continuous Infusion of Lidocaine on Gastrointestinal Tract Function in Normal Horses

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Evaluation of Continuous Infusion of Lidocaine on Gastrointestinal Tract Function in Normal Horses

et al. 2008

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“…Alternatively, gut motility in vivo may be described in terms of "wall movements," the so-called motor patterns that can be referred to as changes in the local phasic and/or tonic activity relative to either longitudinal or circular smooth muscle. The third category of responses considers the changes in luminal pressure, which are suitable to quantify the effect of drugs on the propulsive/mixing activity of limited tracts of the gut, such as the stomach or the proximal intestine (Corazziari, 1982;Karaus and Wienbeck, 1988;Weisbrodt and Bass, 1995;Cullen et al, 1997). It is evident that these different categories of response provide different kinds of information about drug effects on gut motility.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Gastrointestinal Propulsive Activity Using Three Different Models of Peristalsis In Vivo in the Mouse

Poli

Pozzoli

2010

CP Toxicology

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The protocols described in this unit are designed to assess the acute effects of drugs on the propulsive activity of the gastrointestinal muscles in the conscious mouse. These protocols are currently applied to investigate the pharmacological activity of novel compounds undergoing preclinical development and to obtain predictive data needed to advance drugs into clinical trials. Moreover, these methods could be useful in evaluating the functional toxicity by environmental or alimentary pollutants, like xenobiotics and naturally occurring toxins endowed with noxious activity in the control of physiologic peristalsis. The three models detailed-the measurement of gastric emptying, ileal transit, and colonic propulsion-are substantially non-invasive and do not require analgesic pretreatments or the induction of general anesthesia. In contrast to an in vitro approach, these in vivo studies provide a unified understanding of drug effects on gut functionality, in particular when the central nervous system, the extrinsic nerves, or the (neuro)endocrine system is targeted by the test drugs.

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Intestinal contractions and migration behaviour in Hymenolepis diminuta

Sukhdeo¹

1992

International Journal for Parasitology

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In Vivo Techniques for the Study of Gastrointestinal Motility

Cited by 3 publications

References 82 publications

Evaluation of Continuous Infusion of Lidocaine on Gastrointestinal Tract Function in Normal Horses

Evaluation of Continuous Infusion of Lidocaine on Gastrointestinal Tract Function in Normal Horses

Assessment of Gastrointestinal Propulsive Activity Using Three Different Models of Peristalsis In Vivo in the Mouse

Intestinal contractions and migration behaviour in Hymenolepis diminuta

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