In Vivo <sup>19</sup>
F Magnetic Resonance Spectroscopy

Heerschap, Arend

doi:10.1002/9780470034590.emrstm1445

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…There are some excellently written reviews for further reference on PFCs used for oxygen delivery [55,63,73,124,[161][162][163][164], imaging inflammation [48,91,165,166], and cell tracking [65,98,129,[167][168][169]. Refer to the reviews for profound understanding on 19 F MRI used in biomedicine [44,47,56,[170][171][172], PFCs used for various applications [53,74,84,89,[173][174][175][176] and fluorinated compounds including PFCs used for imaging and/or drug delivery [17,24,54,[177][178][179][180][181][182][183]. Being in the tight grip of SARS-CoV-2, PFCs have been proposed as a source of gas exchange in patients in critical conditions and be employed to protect blood cells [184].…”

Section: Biomedical Applications Of Pfc Moleculesmentioning

confidence: 99%

Nanotechnology as a Versatile Tool for 19F-MRI Agent’s Formulation: A Glimpse into the Use of Perfluorinated and Fluorinated Compounds in Nanoparticles

et al. 2022

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Simultaneously being a non-radiative and non-invasive technique makes magnetic resonance imaging (MRI) one of the highly sought imaging techniques for the early diagnosis and treatment of diseases. Despite more than four decades of research on finding a suitable imaging agent from fluorine for clinical applications, it still lingers as a challenge to get the regulatory approval compared to its hydrogen counterpart. The pertinent hurdle is the simultaneous intrinsic hydrophobicity and lipophobicity of fluorine and its derivatives that make them insoluble in any liquids, strongly limiting their application in areas such as targeted delivery. A blossoming technique to circumvent the unfavorable physicochemical characteristics of perfluorocarbon compounds (PFCs) and guarantee a high local concentration of fluorine in the desired body part is to encapsulate them in nanosystems. In this review, we will be emphasizing different types of nanocarrier systems studied to encapsulate various PFCs and fluorinated compounds, headway to be applied as a contrast agent (CA) in fluorine-19 MRI (19F MRI). We would also scrutinize, especially from studies over the last decade, the different types of PFCs and their specific applications and limitations concerning the nanoparticle (NP) system used to encapsulate them. A critical evaluation for future opportunities would be speculated.

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Section: Biomedical Applications Of Pfc Moleculesmentioning

confidence: 99%

Nanotechnology as a Versatile Tool for 19F-MRI Agent’s Formulation: A Glimpse into the Use of Perfluorinated and Fluorinated Compounds in Nanoparticles

et al. 2022

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“…The labeling of CPC with heteronuclei, such as 19 F, 31 P, or 23 Na, natural isotopes with spin of 1/2 that can be directly detected with MRI, could be an excellent alternative to SPIO. Fluorine is especially attractive as it is almost completely absent from biological tissues, which results in a high MR contrast-to-noise ratio and specificity, and it has a similar intrinsic high sensitivity as that of protons. − Typical 19 F MRI labels contain organofluorine compounds, in particular liquid perfluorocarbons (PFCs). Perfluorocarbons are biologically inert and exhibit low toxicity.…”

Section: Introductionmentioning

confidence: 99%

Perfluorocarbon/Gold Loading for Noninvasive in Vivo Assessment of Bone Fillers Using ¹⁹F Magnetic Resonance Imaging and Computed Tomography

Mastrogiacomo

Dou

Koshkina

et al. 2017

ACS Appl. Mater. Interfaces

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Calcium phosphate cement (CPC) is used in bone repair because of its biocompatibility. However, high similarity between CPC and the natural osseous phase results in poor image contrast in most of the available in vivo imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI). For accurate identification and localization during and after implantation in vivo, a composition with enhanced image contrast is needed. In this study, we labeled CPC with perfluoro-15-crown-5-ether-loaded (PFCE) poly(latic-co-glycolic acid) nanoparticles (hydrodynamic radius 100 nm) and gold nanoparticles (diameter 40 nm), as 19F MRI and CT contrast agents, respectively. The resulting CPC/PFCE/gold composite is implanted in a rat model for in vivo longitudinal imaging. Our findings show that the incorporation of the two types of different nanoparticles did result in adequate handling properties of the cement. Qualitative and quantitative long-term assessment of CPC/PFCE/gold degradation was achieved in vivo and correlated to the new bone formation. Finally, no adverse biological effects on the bone tissue are observed via histology. In conclusion, an easy and efficient strategy for following CPC implantation and degradation in vivo is developed. As all materials used are biocompatible, this CPC/PFCE/gold composite is clinically applicable.

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In VivoNMR Spectroscopy – Static Aspects

2018

In Vivo NMR Spectroscopy

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In Vivo ¹⁹ F Magnetic Resonance Spectroscopy

Cited by 4 publications

References 38 publications

Nanotechnology as a Versatile Tool for 19F-MRI Agent’s Formulation: A Glimpse into the Use of Perfluorinated and Fluorinated Compounds in Nanoparticles

Nanotechnology as a Versatile Tool for 19F-MRI Agent’s Formulation: A Glimpse into the Use of Perfluorinated and Fluorinated Compounds in Nanoparticles

Perfluorocarbon/Gold Loading for Noninvasive in Vivo Assessment of Bone Fillers Using ¹⁹F Magnetic Resonance Imaging and Computed Tomography

In VivoNMR Spectroscopy – Static Aspects

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In Vivo 19 F Magnetic Resonance Spectroscopy

Cited by 4 publications

References 38 publications

Nanotechnology as a Versatile Tool for 19F-MRI Agent’s Formulation: A Glimpse into the Use of Perfluorinated and Fluorinated Compounds in Nanoparticles

Nanotechnology as a Versatile Tool for 19F-MRI Agent’s Formulation: A Glimpse into the Use of Perfluorinated and Fluorinated Compounds in Nanoparticles

Perfluorocarbon/Gold Loading for Noninvasive in Vivo Assessment of Bone Fillers Using 19F Magnetic Resonance Imaging and Computed Tomography

In VivoNMR Spectroscopy – Static Aspects

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Product

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In Vivo ¹⁹ F Magnetic Resonance Spectroscopy

Perfluorocarbon/Gold Loading for Noninvasive in Vivo Assessment of Bone Fillers Using ¹⁹F Magnetic Resonance Imaging and Computed Tomography