In vivo study of nanostructured diopside (CaMgSi2O6) coating on magnesium alloy as biodegradable orthopedic implants

Razavi, Mehdi; Fathi, Mohammadhossein; Savabi, Omid; Razavi, Seyed Mohammad Javad; Heidari, Fariba; Manshaei, Maziar; Vashaee, Daryoosh; Tayebi, Lobat

doi:10.1016/j.apsusc.2014.05.130

Cited by 63 publications

(37 citation statements)

References 39 publications

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“…14,15 If the magnesium implants are being used to fix damage bone tissue, they are likely to lose their mechanical integrity earlier than tissue healing of bone due to their rapid corrosion and low bioactivity. 16,17 Recently, some research has been planned to slow down the corrosion rate of magnesium alloys. 18,19 Surface modification and coating by various materials has been employed as a proper approach for controlling the corrosion properties of metals since decades ago with excellent rate of success.…”

Section: Materials Science and Engineering: C Vol 48 (March 2015)mentioning

confidence: 99%

In vivo assessments of bioabsorbable AZ91 magnesium implants coated with nanostructured fluoridated hydroxyapatite by MAO/EPD technique for biomedical applications

Razavi

Fathi

Savabi

et al. 2015

Materials Science and Engineering: C

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Although magnesium (Mg) is a unique biodegradable metal which possesses mechanical property similar to that of the natural bone and can be an attractive material to be used as orthopedic implants, its quick corrosion rate restricts its actual clinical applications. To control its rapid degradation, we have modified the surface of magnesium implant using fluoridated hydroxyapatite (FHA: Ca10(PO4)6OH2 − xFx) through the combined micro-arc oxidation (MAO) and electrophoretic deposition (EPD) techniques, which was NOT THE PUBLISHED VERSION; this is the author's final, peer-reviewed manuscript. The published version may be accessed by following the link in the citation at the bottom of the page. 2015): pg. 21-27. DOI. This article is © Elsevier and permission has been granted for this version to appear in e-Publications@Marquette. Elsevier does not grant permission for this article to be further copied/distributed or hosted elsewhere without the express permission from Elsevier. Materials Science and Engineering: C, Vol 48 (March3 presented in our previous paper. In this article, the biocompatibility examinations were conducted on the coated AZ91 magnesium alloy by implanting it into the greater trochanter area of rabbits. The results of the in vivo animal test revealed a significant enhancement in the biocompatibility of FHA/MAO coated implant compared to the uncoated one. By applying the FHA/MAO coating on the AZ91 implant, the amount of weight loss and magnesium ion release in blood plasma decreased. According to the histological results, the formation of the new bone increased and the inflammation decreased around the implant. In addition, the implantation of the uncoated AZ91 alloy accompanied by the release of hydrogen gas around the implant; this release was suppressed by applying the coated implant. Our study exemplifies that the surface coating of magnesium implant using a bioactive ceramic such as fluoridated hydroxyapatite may improve the biocompatibility of the implant to make it suitable as a commercialized biomedical product.

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Section: Materials Science and Engineering: C Vol 48 (March 2015)mentioning

confidence: 99%

In vivo assessments of bioabsorbable AZ91 magnesium implants coated with nanostructured fluoridated hydroxyapatite by MAO/EPD technique for biomedical applications

Razavi

Fathi

Savabi

et al. 2015

Materials Science and Engineering: C

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“…However, it is well known that the base Mg corrodes too quickly in vivo for bioabsorbable stent applications, often experiencing extensive material loss even within 1 month [18] and complete degradation as early as 3 months [24]. Mg is also susceptible to corrosion fatigue and mechanical failure [26–28] and generates a rapid buildup of hydrogen gas that can complicate tissue regeneration [29,30]. Alloying has successfully addressed some of these concerns.…”

Section: Introductionmentioning

confidence: 99%

Long-term surveillance of zinc implant in murine artery: Surprisingly steady biocorrosion rate

et al. 2017

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Metallic zinc implanted into the abdominal aorta of rats out to 6 months has been demonstrated to degrade while avoiding responses commonly associated with the restenosis of vascular implants. However, major questions remain regarding whether a zinc implant would ultimately passivate through the production of stable corrosion products or via a cell mediated fibrous encapsulation process that prevents the diffusion of critical reactants and products at the metal surface. Here, we have conducted clinically relevant long term in vivo studies in order to characterize late stage zinc implant biocorrosion behavior and products to address these critical questions. We found that zinc wires implanted in the murine artery exhibit steady corrosion without local toxicity for up to at least 20 months post-implantation, despite a steady buildup of passivating corrosion products and intense fibrous encapsulation of the wire. Although fibrous encapsulation was not able to prevent continued implant corrosion, it may be related to the reduced chronic inflammation observed between 10 and 20 months post-implantation. X-ray elemental and infrared spectroscopy analyses confirmed zinc oxide, zinc carbonate, and zinc phosphate as the main components of corrosion products surrounding the Zn implant. These products coincide with stable phases concluded from Pourbaix diagrams of a physiological solution and in vitro electrochemical impedance tests. The results support earlier predictions that zinc stents could become successfully bio-integrated into the arterial environment and safely degrade within a time frame of approximately 1 – 2 years.

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“…Apart from the loss of mechanical integrity, such rapid degradation creates local alkalization, which affects the physiological microenvironment around the implant. A pH increase above 7.8 may result in alkaline poisoning (Song, ) and inflammatory responses (Li et al, ; Razavi et al, ), which explains the background of the requirement. Moderate hydrogen release : The corrosion of magnesium‐based implants forms hydrogen (Witte et al, ). Despite the rapid diffusion and absorption (Aghion, Levy, & Ovadia, ; Dziuba et al, ; Gu, Xie, Li, Zheng, & Qin, ; Hänzi, Gerber, Schinhammer, Löffler, & Uggowitzer, ; Hou et al, ; Liu, Yang, Tan, Li, & Zhang, ; Pichler et al, ; Razavi et al, ; Song & Atrens, ; Witte et al, ; Witte et al, ) of this gas, a moderate and controlled release mechanism is required during the degradation process.…”

Section: Results Of Empirical Investigationmentioning

confidence: 99%

“…A pH increase above 7.8 may result in alkaline poisoning (Song, ) and inflammatory responses (Li et al, ; Razavi et al, ), which explains the background of the requirement. Moderate hydrogen release : The corrosion of magnesium‐based implants forms hydrogen (Witte et al, ). Despite the rapid diffusion and absorption (Aghion, Levy, & Ovadia, ; Dziuba et al, ; Gu, Xie, Li, Zheng, & Qin, ; Hänzi, Gerber, Schinhammer, Löffler, & Uggowitzer, ; Hou et al, ; Liu, Yang, Tan, Li, & Zhang, ; Pichler et al, ; Razavi et al, ; Song & Atrens, ; Witte et al, ; Witte et al, ) of this gas, a moderate and controlled release mechanism is required during the degradation process. Rapid production of large amounts of hydrogen can promote the loss of mechanical integrity due to hydrogen embrittlement (Choudhary & Singh Raman, ; Gu, Zhou, Zheng, Cheng, et al, ; Jafari et al, ; Kannan, ), the formation of temporary gas cavities (Witte et al, ) and/or the impairment of blood circulation (Song, ).…”

Section: Results Of Empirical Investigationmentioning

confidence: 99%

Development of magnesium implants by application of conjoint‐based quality function deployment

Siefen

Höck

2019

J Biomedical Materials Res

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Biodegradable magnesium‐based implants are the subject of a great deal of research for different orthopedic and vascular applications. The targeted design and properties depend on the specific medical function and location in the body. Development of the biomaterial requires a comprehensive understanding of the biological interaction between the implant and the host tissue, as well as of the behavior in the physiological environment in vivo. Research into and the development of innovative magnesium implants entails interdisciplinary research efforts and communication between materials science, bioscience, and medical experts. The present study provides a transparent planning and communication tool for market‐oriented implant development processes. The objective was to identify medical needs at an early stage of the development process and to quantify the importance of the engineering characteristics of different research fields that cater to specific implant requirements. The method is demonstrated by the performance of a survey‐based conjoint analysis, which was integrated into a quality function deployment approach. Twenty‐seven medical professionals and 29 biomaterial scientists assessed the importance of identified medical requirements, whereby the control of mechanical integrity and degradation along with nontoxicity and nonimmunogenicity showed the highest number of preferences. The evaluation of implant options by 31 experts indicated that the engineering characteristic with the highest importance was the condition and sterilization of the surface. These values can be used to set priorities in strategic decisions. Research trials can be aligned to medical preferences, ensuring high product quality and an effective development process. This is the first paper to report on the application of conjoint‐based quality function deployment in biomaterial research.

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In vivo study of nanostructured diopside (CaMgSi2O6) coating on magnesium alloy as biodegradable orthopedic implants

Cited by 63 publications

References 39 publications

In vivo assessments of bioabsorbable AZ91 magnesium implants coated with nanostructured fluoridated hydroxyapatite by MAO/EPD technique for biomedical applications

In vivo assessments of bioabsorbable AZ91 magnesium implants coated with nanostructured fluoridated hydroxyapatite by MAO/EPD technique for biomedical applications

Long-term surveillance of zinc implant in murine artery: Surprisingly steady biocorrosion rate

Development of magnesium implants by application of conjoint‐based quality function deployment

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