In Vivo Studies of Man-Made Mineral Fibers. Fibrosis-Related Factors.

Morimoto, Yasuo; Tanaka, Isamu

doi:10.2486/indhealth.39.106

Cited by 12 publications

(9 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies on humans and rats have shown that CC16 is a sensitive biomarker of respiratory epithelial injury in exposures to welder fumes, glutaraldehyde, nitric oxides, or Al foundry dusts [18][19][20][21][22][23]. Clara cell proteins are involved in the pathogenic mechanisms leading to fibrosis [15,24], chronic obstructive pulmonary disease (COPD) [25,26], and asthma in humans [27][28][29] and in murine asthma model [30,31]. Low level of CC16 was observed in serum and bronchoalveolar lavage fluid (BAL) of active smokers [32].…”

Section: Introductionmentioning

confidence: 99%

Serum Clara Cell Protein as an Indicator of Pulmonary Impairment in Occupational Exposure at Aluminum Foundry

Hałatek¹,

Trzcinka-Ochocka²,

Matczak³

et al. 2006

International Journal of Occupational Medicine and Environmental Health

View full text Add to dashboard Cite

Objectives: Although some of the exposures in aluminum (Al) smelting have been well characterized, and respiratory disorders in aluminum production workers are well known, the relationship between internal aluminum loads and appropriate lung biomarkers have not been elucidated. The aim of our work was to carry out a comprehensive investigation in workers employed in the Aluminum Foundry Casting Department with special reference to currently existing hygiene standards, known as threshold limit values (TLV) based on aluminum effects on the respiratory system. The measurement of serum anti-inflammatory Clara cell protein (CC16) was employed as a peripheral marker of the lung epithelium function. Materials and Methods: A group of 50 casting smelters, 5 locksmiths, 11 sawyers and auxiliary workers exposed to dust containing 14% of aluminum, and a group of 42 controls were examined. Respiratory function tests were performed and forced volume capacity (FVC), forced expiratory volume in 1 s (FEV 1 ), forced expiratory volume in the first percent (FEV 1 %), forced expiratory flows in 50% VC (FEV 50 ), and markers of foundry workers' exposure and body burden, Al concentration in the breathing zone, blood and urine, biomarkers of the effects of exposure, concentration of CC16 and hyaluronic acid (HA) in serum were determined in all examined workers. Additional measurements comprised determinations of serum iron (Fe) levels, myeloperoxidase (MPO), eosinophil cationic protein (ECP), immunoglobulin E (IgE), glutathione S-transferase (GST), and superoxide dismutase (SOD) activity in erythrocytes. Results: The group of casting smelters was characterized by the highest levels of aluminum in urine (Al-U) (43.7 mg L -1 ), high levels of MPO, ECP and IgE, high SOD activity, low CC16 levels, and low activity of GST. Lower Al-U excretion was observed in locksmiths (35.2 mg L -1 ) and sawyers (21.7 mg L -1 ). Serum CC16 proved to be the most sensitive biomarker, showing high inverse relationship with serum Al (Al-S) concentrations in casting smelters (p = 0.006). Conclusions: The study showed that in conditions of occupational exposure, dusts containing Al 2 O 3 < 1 mg m -3 cause changes in the respiratory system and biomarkers in serum, especially in CC16, connected with altered functioning of this system. Changes in concentrations of the examined biomarkers and also in respiratory parameters of the study subjects were observed when Al-U concentration was > 40 mg L -1 .

show abstract

Section: Introductionmentioning

confidence: 99%

Serum Clara Cell Protein as an Indicator of Pulmonary Impairment in Occupational Exposure at Aluminum Foundry

Hałatek¹,

Trzcinka-Ochocka²,

Matczak³

et al. 2006

International Journal of Occupational Medicine and Environmental Health

View full text Add to dashboard Cite

show abstract

“…Fibrogeneity of glass wool fibers as shown in in vitro and in vivo studies [Ishihara, 2001;Morimoto and Tanaka, 2001] and their long biopersistence in the lungs support the possibility that those fibers are the causative agent of this pulmonary process.…”

Section: Discussionmentioning

confidence: 95%

“…The persistence of these fibers in the induced sputum 4 years after biopsy (and more than 9 years after the probable last exposure) indicates a very long bio-persistence [Oberdorster, 2000;Morimoto and Tanaka, 2001;Tanaka et al, 2001].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary fibrosis in a patient with exposure to glass wool fibers

Guber

Lerman

et al. 2006

American J Industrial Med

View full text Add to dashboard Cite

Glass wool or vitreous fibers are non-crystalline, fibrous inorganic substances (silicates) made primarily from rock, slag, glass, or other processed minerals. They belong to the man-made mineral fibers (MMMFs) group and their respiratory effects are well described by De Vuyst et al. [1995]. The authors pointed out the absence of firm evidence that exposure to these fibers is associated with lung fibrosis, pleural lesions, or non-specific respiratory disease in humans. Because of this observation, we find it of importance to present a case of interstitial fibrosis, which implies a direct association between long-term exposure to glass wool and the clinical outcome.

show abstract

“…Increased numbers of bronchoalveolar lavage fluid (BALF) cells after asbestos or other fiberexposure as a result of inflammatory response have been described by numerous authors (Hurbankova & Kaiglova, 1999;Greim et al, 2001;Morimoto & Tanaka, 2001;Osinubi et al, 2000). In our study, a significantly increased number of BALF cells after exposure to amosite in comparison with the control group was observed in the smoker plus 60 mg/m 3 fiber group (by 11.4 %) as well as in the corresponding-dose, non-smoker group (by about 16%).…”

Section: Combined Effect Of Mineral Fibers and Tobacco Smoke On Respimentioning

confidence: 99%

Immune System and Environmental Xenobiotics - The Effect of Selected Mineral Fibers and Particles on the Immune Response

Kuricová¹,

Tulinská²,

Líšková³

et al. 2012

Recent Advances in Immunology to Target Cancer, Inflammation and Infections

View full text Add to dashboard Cite

In Vivo Studies of Man-Made Mineral Fibers. Fibrosis-Related Factors.

Cited by 12 publications

References 47 publications

Serum Clara Cell Protein as an Indicator of Pulmonary Impairment in Occupational Exposure at Aluminum Foundry

Serum Clara Cell Protein as an Indicator of Pulmonary Impairment in Occupational Exposure at Aluminum Foundry

Pulmonary fibrosis in a patient with exposure to glass wool fibers

Immune System and Environmental Xenobiotics - The Effect of Selected Mineral Fibers and Particles on the Immune Response

Contact Info

Product

Resources

About