In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease

Activity on Trypanosoma cruzi, erythrocytes lysis and biologically relevant physicochemical properties of Pd(II) and Pt(II) complexes of thiosemicarbazones derived from 1-indanones

“…The occurrence of the epimastigote form of T. cruzi as an obligate mammalian intracellular stage has been reevaluated and confirmed [42][43][44]. Furthermore, it should be noted that a good correlation between antiproliferative epimastigote activity and in vivo anti-T. cruzi activity was observed with several compounds [45][46][47][48][49].…”

5-Nitro-2-furyl derivative actives against Trypanosoma cruzi: Preliminary in vivo studies

“…In the in vivo studies wild strain isolated from Uruguayan patients was employed [19]. In vivo anti-Chagasic activity was Table 1 Chemical structures of 5-nitro-2-furyl derivatives assayed and in vitro trypanocidal activities on epimastigote forms (Tulahuen 2 strain).…”

“…On day 45th after the beginning of the treatment the animals were sacrificed and the dissected organs histologicaly studied. The presence of amastigotes and inflammatory infiltrates in heart and muscle and liver necrosis and congestion was determined by two independents observers [19].…”

“…The effect of each drug was weekly evaluated by determining the trypomastigote levels. Parasitemia determinations were carried out as described previously [12,19]. On day 45th after the beginning of the treatment the animals were sacrificed and the dissected organs histologicaly studied.…”

Caracterização no estado sólido de insumos farmacêuticos ativos: planejamento racional de novas formas cristalinas.

“…diferentes fármacos dentro de uma fase cristalina [76]. Algumas das principais funcionalidades estruturais que devem ser levadas em consideração compreendem a presença de grupos receptores e doadores de hidrogênio em interações intermoleculares, de anéis aromáticos capazes de realizar interações do tipo -, e de grupos hidrofóbicos, entre outras.…”