In vivo strain assessment of the abdominal aortic aneurysm

Satriano, Alessandro; Rivolo, Simone; Martufi, Giampaolo; Finol, Ender A.; Martino, Elena S. Di

doi:10.1016/j.jbiomech.2014.11.016

Cited by 32 publications

(35 citation statements)

References 33 publications

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“…The calculation of strain is unaffected by assumptions about the mechanical properties of the structure. Consequently, it has been proposed as an alternative method to assess the mechanics of an aneurysm [60]. The advantages of mapping strains rather than stresses is that strain computation derives directly from motion analysis and does not require the definition of a material constitutive model.…”

Section: Strain Analysismentioning

confidence: 99%

“…A mathematical optimization procedure is usually used to estimate the set of unknown material properties that allows matching the measured pressure load with the corresponding observed deformation. Noninvasive methods to measure pressure are currently being proposed, and the combination of modern dynamic imaging and computational technology enables us to noninvasively assess the aortic wall deformation over the cardiac cycle [60].…”

Section: Assessment Of Aortic Wall Strengthmentioning

confidence: 99%

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Is There a Role for Biomechanical Engineering in Helping to Elucidate the Risk Profile of the Thoracic Aorta?

Martufi

Forneris

Appoo

et al. 2016

The Annals of Thoracic Surgery

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Section: Strain Analysismentioning

confidence: 99%

Section: Assessment Of Aortic Wall Strengthmentioning

confidence: 99%

Is There a Role for Biomechanical Engineering in Helping to Elucidate the Risk Profile of the Thoracic Aorta?

Martufi

Forneris

Appoo

et al. 2016

The Annals of Thoracic Surgery

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“…18,19 Local vessel parameters can be derived from aortic strain: pressure strain elastic modulus and vessel distensibility. A major drawback of these parameters is the need of blood pressure values, as continuous invasive blood pressure recording is usually not possible during image acquisition.…”

Section: Doesn't Have To Be Numbered As It Is the Only Table?mentioning

confidence: 99%

“…Novel mechanical parameters derived by others show a promising result in the understanding and quantification of the local properties of the healthy and diseased aorta. 18,19 Finding a new parameter that can be derived from widely available CTA images and that could estimate disease progression would be a game changer for patients with aortic disease.…”

Section: Doesn't Have To Be Numbered As It Is the Only Table?mentioning

confidence: 99%

Thoracic aortic strain can affect endograft sizing in young patients

Csobay-Novák

Fontanini

Szilágyi

et al. 2015

Journal of Vascular Surgery

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“…Current clinical guidelines recommend surgical intervention for aneurysms above 5.5 cm to prevent rupture, but this metric lacks sensitivity and specificity as smaller aneurysms may rupture and larger aneurysms may remain stable[3]. Rupture is a mechanical failure of the aneurysm in which the internal stress (e.g., from aortic blood pressure) exceeds the tissue strength; therefore, evaluating arterial mechanics in the aneurysm, such as wall stress or distensibility[4], may be a superior rupture assessment. In fact, computer models of aneurysm peak wall stress have shown improved specificity compared to size-based assessments[5,6].…”

Section: Introductionmentioning

confidence: 99%

Telemetric Blood Pressure Assessment in Angiotensin II-Infused ApoE-/- Mice: 28 Day Natural History and Comparison to Tail-Cuff Measurements

et al. 2015

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Abdominal aortic aneurysm (AAA) is a disease of the aortic wall, which can progress to catastrophic rupture. Assessment of mechanical characteristics of AAA, such as aortic distensibility, may provide important insights to help identify at-risk patients and understand disease progression. While the majority of studies on this topic have focused on retrospective patient data, recent studies have used mouse models of AAA to prospectively evaluate the evolution of aortic mechanics. Quantification of aortic distensibility requires accurate measurement of arterial blood pressure, particularly pulse pressure, which is challenging to perform accurately in murine models. We hypothesized that volume/pressure tail-cuff measurements of arterial pulse pressure in anesthetized mice would have sufficient accuracy to enable calculations of aortic distensibility with minimal error. Telemetry devices and osmotic mini-pumps filled with saline or angiotensin-II were surgically implanted in male apolipoprotein-E deficient (ApoE-/-) mice. Blood pressure in the aortic arch was measured continuously via telemetry. In addition, simultaneous blood pressure measurements with a volume/pressure tail-cuff system were performed under anesthesia at specific intervals to assess agreement between techniques. Compared to controls, mice infused with angiotensin-II had an overall statistically significant increase in systolic pressure, with no overall difference in pulse pressure; however, pulse pressure did increase significantly with time. Systolic measurements agreed well between telemetry and tail-cuff (coefficient of variation = 10%), but agreement of pulse pressure was weak (20%). In fact, group-averaged pulse pressure from telemetry was a better predictor of a subject’s pulse pressure on a given day than a simultaneous tail-cuff measurement. Furthermore, these approximations introduced acceptable errors (15.1 ± 12.8%) into the calculation of aortic distensibility. Contrary to our hypothesis, we conclude that tail-cuff measures of arterial pulse pressure have limited accuracy. Future studies of aneurysm mechanics using the ApoE-/-/angiotensin-II model would be better in assuming pulse pressure profiles consistent with our telemetry findings instead of attempting to measure pulse pressure in individual mice.

show abstract

In vivo strain assessment of the abdominal aortic aneurysm

Cited by 32 publications

References 33 publications

Is There a Role for Biomechanical Engineering in Helping to Elucidate the Risk Profile of the Thoracic Aorta?

Is There a Role for Biomechanical Engineering in Helping to Elucidate the Risk Profile of the Thoracic Aorta?

Thoracic aortic strain can affect endograft sizing in young patients

Telemetric Blood Pressure Assessment in Angiotensin II-Infused ApoE-/- Mice: 28 Day Natural History and Comparison to Tail-Cuff Measurements

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