In vivo sensing of cutaneous edema: A comparative study of diffuse reflectance, Raman spectroscopy and multispectral imaging

Budylin, Gleb S.; Davydov, D. A.; Zlobina, N. V.; Baev, Alexey V.; Artyushenko, V.; Yakimov, Boris P.; Shirshin, Evgeny A.

doi:10.1002/jbio.202100268

Cited by 8 publications

(14 citation statements)

References 56 publications

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“…Moreover, the accuracy of bilirubin determination might also be increased with the inclusion of optoacoustic spectroscopy analysis, 39 as this method is rapidly developing. 40,41 Thus, the proposed solution fits the upcoming worldwide trend of optical noninvasive monitoring of various endogenous chromophores, such as oxy-and deoxyhemoglobin, 42 water 43,44 and melanin, 45,46 as well as metabolic activity. 47…”

Section: Resultsmentioning

confidence: 97%

Noninvasive, continuous fluorescence monitoring of bilirubin photodegradation

Perkov¹,

Gorin²

2023

Phys. Chem. Chem. Phys.

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Section: Resultsmentioning

confidence: 97%

Noninvasive, continuous fluorescence monitoring of bilirubin photodegradation

Perkov¹,

Gorin²

2023

Phys. Chem. Chem. Phys.

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“…The OD spectra were fitted by a linear combination of the absorption spectra of the main components (water and lipids) and the baseline, which takes into account the contribution of the absorption of other chromophores (oxyhemoglobin, deoxyhemoglobin) and scattering: 9,27,28 E Q -T A R G E T ; t e m p : i n t r a l i n k -; e 0 0 2 ; 1 1 6 ; 1 4 8…”

Section: Processing Of Diffuse Reflection Spectramentioning

confidence: 99%

“… 8 Hence, the necessity of water content assessment stimulates the development of appropriate techniques, including those based on optical spectroscopy. 9 …”

Section: Introductionmentioning

confidence: 99%

“…8 Hence, the necessity of water content assessment stimulates the development of appropriate techniques, including those based on optical spectroscopy. 9 Optical methods based on molecular contrast, i.e., spectroscopic signatures of water molecules, have been numerously suggested in the literature as fast, sensitive, and non-invasive tools for assessing hydration in vivo. Confocal Raman and THz spectroscopy are mainly applied for studying the skin's upper (epidermis) layer.…”

Section: Introductionmentioning

confidence: 99%

“…3,12,13 For instance, in heart failure patients, peripheral edema was analyzed with short-wave NIR imaging. 2 Cutaneous edema induced by histamine application was studied with diffuse reflectance spectroscopy (DRS), 9,14 Raman fiber probe, 9 and multispectral NIR imaging. 2,9,15 The question of choosing the optimal distances between the source and the detector for leg edema evaluation were discussed in Nanjo et al 14 Since the optical and morphological properties of the skin differ significantly, 16 the assessment of hydration and cutaneous edema of the skin by optical methods is a complicated task.…”

Section: Introductionmentioning

confidence: 99%

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Monitoring the skin structure during edema in vivo with spatially resolved diffuse reflectance spectroscopy

Davydov,

Budylin,

Baev

et al. 2023

J. Biomed. Opt.

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. Significance Edema occurs in the course of various skin diseases. It manifests itself in changes in water concentrations in skin layers: dermis and hypodermis and their thicknesses. In medicine and cosmetology, objective tools are required to assess the skin’s physiological parameters. The dynamics of edema and the skin of healthy volunteers were studied using spatially resolved diffuse reflectance spectroscopy (DRS) in conjunction with ultrasound (US). Aim In this work, we have developed a method based on DRS with a spatial resolution (SR DRS), allowing us to simultaneously assess water content in the dermis, dermal thickness, and hypodermal thickness. Approach An experimental investigation of histamine included edema using SR DRS under the control of US was conducted. An approach for skin parameter determination was studied and confirmed using Monte-Carlo simulation of diffuse reflectance spectra for a three-layered system with the varying dermis and hypodermis parameters. Results It was shown that an interfiber distance of 1 mm yields a minimal relative error of water content determination in the dermis equal to 9.3%. The lowest error of hypodermal thickness estimation was achieved with the interfiber distance of 10 mm. Dermal thickness for a group of volunteers (7 participants, 21 measurement sites) was determined using SR DRS technique with an 8.3% error using machine learning approaches, taking measurements at multiple interfiber distances into account. Hypodermis thickness was determined with root mean squared error of 0.56 mm for the same group. Conclusions This study demonstrates that measurement of the skin diffuse reflectance response at multiple distances makes it possible to determine the main parameters of the skin and will serve as the basis for the development and verification of an approach that works in a wide range of skin structure parameters.

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Rapid low‐cost hyperspectral imaging system for quantitative assessment of infantile hemangioma

Perkov,

Vorobev,

Kurochkin

et al. 2023

Journal of Biophotonics

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Hemangioma, the predominant benign tumor occurring in infancy, exhibits a wide range of prognoses and associated outcomes. The accurate determination of prognosis through noninvasive imaging modalities holds essential importance in enabling effective personalized treatment strategies and minimizing unnecessary surgical interventions for individual patients. The present study focuses on advancing the personalized prognosis of hemangioma by leveraging noninvasive optical sensing technologies by the development of a novel rapid hyperspectral sensor (image collection in 5 s, lateral resolution of 10 μm) that is capable of quantifying hemoglobin oxygenation and vascularization dynamics during the course of tumor evolution. We have developed a quantitative parameter for hemangioma assessment, that demonstrated agreement with the clinician's conclusion in 90% among all cases during clinical studies on six patients, who visited clinician from two to four times. The presented methodology has potential to be implemented as a supportive tool for accurate hemangioma diagnostics in clinics.

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In vivo sensing of cutaneous edema: A comparative study of diffuse reflectance, Raman spectroscopy and multispectral imaging

Abstract: Quantitative noninvasive assessment of water content in tissues is important for biomedicine. Optical spectroscopy is potentially capable of solving this problem; however, its applicability for clinical diagnostics remains questionable. The

Cited by 8 publications

References 56 publications

Noninvasive, continuous fluorescence monitoring of bilirubin photodegradation

Noninvasive, continuous fluorescence monitoring of bilirubin photodegradation

Monitoring the skin structure during edema in vivo with spatially resolved diffuse reflectance spectroscopy

Rapid low‐cost hyperspectral imaging system for quantitative assessment of infantile hemangioma

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