In Vivo Retinal Nerve Fiber Layer Thickness Measured by Optical Coherence Tomography Predicts Visual Recovery after Surgery for Parachiasmal Tumors

Danesh‐Meyer, Helen V.; Papchenko, Taras; Savino, Peter J.; Law, Andrew; Evans, James G.; Gamble, Greg

doi:10.1167/iovs.07-1127

Cited by 190 publications

(160 citation statements)

References 32 publications

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“…A strong correlation was found between the initial visual field defect and the mean RNFL thickness. The prognostic value of RNFL thickness was independent from the effects of age and duration of symptoms [91]. These findings suggest that RNFL thinning is the result of RGC cell axonal degeneration and the product of compression of the anterior visual pathway fibers by the underlying chiasmal mass lesion.…”

Section: Compressive and Infiltrative Optic Neuropathiesmentioning

confidence: 75%

“…OCT in several small studies has been useful in predicting visual outcome following the treatment of pituitary adenomas [91,92]. In a study of 19 patients, a greater RNFL thickness prior to treatment increased the probability of visual recovery following treatment (17 surgical and 2 pharmacological treatments).…”

Section: Compressive and Infiltrative Optic Neuropathiesmentioning

confidence: 99%

“…In a study of 19 patients, a greater RNFL thickness prior to treatment increased the probability of visual recovery following treatment (17 surgical and 2 pharmacological treatments). For each increase in RNFL by 1 μm, the odds of complete recovery were multiplied by 1.29 [91]. A strong correlation was found between the initial visual field defect and the mean RNFL thickness.…”

Section: Compressive and Infiltrative Optic Neuropathiesmentioning

confidence: 99%

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Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

et al. 2011

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Summary: Axonal and neuronal degeneration are important features of multiple sclerosis (MS) and other neurologic disorders that affect the anterior visual pathway. Optical coherence tomography (OCT) is a non-invasive technique that allows imaging of the retinal nerve fiber layer (RNFL), a structure which is principally composed of ganglion cell axons that form the optic nerves, chiasm, and optic tracts. Since retinal axons are nonmyelinated until they penetrate the lamina cribrosa, the RNFL is an ideal structure (no other central nervous system tract has this unique arrangement) for visualizing the processes of neurodegeneration, neuroprotection and, potentially, even neuro-repair. OCT is capable of providing high-resolution reconstructions of retinal anatomy in a rapid and reproducible fashion and permits objective analysis of the RNFL (axons) as well as ganglion cells and other neurons in the macula. In a systematic OCT examination of multiple sclerosis (MS) patients, RNFL thickness and macular volumes are reduced when compared to disease-free controls.Conspicuously, these changes, which signify disorganization of retinal structural architecture, occur over time even in the absence of a history of acute demyelinating optic neuritis. RNFL axonal loss in MS is most severe in those eyes with a corresponding reduction in low-contrast letter acuity (a sensitive vision test involving the perception of gray letters on a white background) and in those patients who exhibit the greatest magnitude of brain atrophy, as measured by validated magnetic resonance imaging techniques. These unique structure-function correlations make the anterior visual pathway an ideal model for investigating the effects of standard and novel therapies that target axonal and neuronal degeneration. We provide an overview of the physics of OCT, its unique properties as a non-invasive imaging technique, and its potential applications toward understanding mechanisms of brain tissue injury in MS, other optic neuropathies, and neurologic disorders.

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Section: Compressive and Infiltrative Optic Neuropathiesmentioning

confidence: 75%

Section: Compressive and Infiltrative Optic Neuropathiesmentioning

confidence: 99%

Section: Compressive and Infiltrative Optic Neuropathiesmentioning

confidence: 99%

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Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

et al. 2011

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“…OCT has shown high sensitivity, specificity and reproducibility in assessing RNFL and GCC thickness and in detecting early damage in glaucoma and compressive optic neuropathy. [10][11][12][13][14][15][16][17] In the absence of glaucomatous VF defects, RNFL and GCC thinning in the eyes with TAO, OHT and normal optic discs could suggest the presence of an early optic neuropathy.…”

Section: Discussionmentioning

confidence: 99%

“…[18][19][20] In compressive optic neuropathy, RNFL thinning is related to the site of compression. 17,21 Localized RNFL defects could be attributed to early glaucoma and may require an antiglaucomatous treatment. 22,23 The purpose of this study is to detect the extent to which the RNFL and also GCC thickness values are affected in patients with TAO using the RTVue-100 FD-OCT system.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Retinal Nerve Fiber Layer and Ganglion Cell Complex with Optical Coherence Tomography in Thyroid-Associated Orbitopathy

Dirim¹,

Sendul²,

Akarsu³

et al. 2017

World Clin J Med Sci

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Utility of Optical Coherence Tomography in the Diagnosis and Management of Optic Neuropathy in Patients with Fibrous Dysplasia

Pan

FitzGibbon

Vitale

et al. 2020

Journal of Bone and Mineral Research

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Optic neuropathy (ON) is a highly disabling complication of fibrous dysplasia (FD). The optimal test for identifying and monitoring ON in FD is unknown. Optical coherence tomography (OCT) is an imaging modality that detects retinal nerve fiber layer (RNFL) thinning, a sign of optic nerve atrophy. The purpose of this study was to (i) assess the ability of OCT RNFL thickness measurements to identify ON in FD; (ii) compare the performance of RNFL thickness to computed tomography measurements; and (iii) examine changes in RNFL thickness over time to assess disease progression. A retrospective cohort study was performed to assess subjects (n = 70) who underwent neuro-ophthalmologic examination, including OCT. The diagnostic utility of RNFL thickness was determined using receiver operator characteristic (ROC) curve analysis, and the accuracy was compared with computed tomography measurements. The relationship between RNFL thickness and age was assessed cross-sectionally, using generalized estimating equation methodology, and longitudinally, using a generalized mixed model. Eleven subjects were identified with ON. RNFL thickness identified ON (area under curve = 0.997, p < 0.0001) with sensitivity and specificity of 100% and 95%, respectively, when using the diagnostic criterion of ≤71 μm. RNFL thickness outperformed computed tomography measurements of optic canal narrowing and optic nerve stretch. Subjects with ON exhibited a greater decrease in RNFL thickness with each year of age (−0.70 μm/year, p < 0.001) than subjects with normal vision (−0.16 μm/year, p < 0.05). When assessed longitudinally, subjects with normal vision demonstrated an increase in RNFL thickness until approximately age 20 years that decreased thereafter. In contrast, subjects with ON exhibited an earlier decrease in RNFL thickness during adolescence. In conclusion, RNFL thickness of ≤71 μm accurately identified ON in this population. By establishing the difference in rate of RNFL thinning in patients with and without ON, clinicians may distinguish between patients at risk for ON and intervene before irreversible damage.

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In Vivo Retinal Nerve Fiber Layer Thickness Measured by Optical Coherence Tomography Predicts Visual Recovery after Surgery for Parachiasmal Tumors

Abstract: Patients who have objectively measurable RNFL loss at the time of surgery for chiasmal compressive lesions are less likely to have return of VA or VF after surgery.

Cited by 190 publications

References 32 publications

Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

Comparison of Retinal Nerve Fiber Layer and Ganglion Cell Complex with Optical Coherence Tomography in Thyroid-Associated Orbitopathy

Utility of Optical Coherence Tomography in the Diagnosis and Management of Optic Neuropathy in Patients with Fibrous Dysplasia

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