In Vivo Response of Growth Plate to Biodegradable Mg-Ca-Zn Alloys Depending on the Surface Modification

Song, Mi Hyun; Yoo, Won Joon; Cho, Tae Joon; Park, Yong Koo; Lee, Wang Jae; Choi, In Ho

doi:10.3390/ijms20153761

Cited by 12 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The DRs calculated for both implantation sites accounted 0.23–0.75 mm/year. This lies within the range of DRs of different Mg alloys found in the literature [ 30 , 31 ]. Chaya et al .…”

Section: Discussionsupporting

confidence: 82%

Degradation behavior and osseointegration of Mg–Zn–Ca screws in different bone regions of growing sheep: a pilot study

Marek

Ćwieka

Donohue

et al. 2022

Regenerative Biomaterials

View full text Add to dashboard Cite

Magnesium (Mg)-based implants are highly attractive for the orthopedic field and may replace titanium (Ti) as support for fracture healing. To determine the implant-bone-interaction in different bony regions, we implanted Mg-based alloy ZX00 (Mg < 0.5 Zn < 0.5 Ca, in wt%) and Ti-screws into the distal epiphysis and distal metaphysis of sheep tibiae. The implant degradation and osseointegration were assessed in vivo and ex vivo after 4, 6 and 12 weeks, using a combination of clinical computed tomography (cCT), medium-resolution micro CT (µCT) and high-resolution synchrotron radiation µCT (SRµCT). Implant volume loss, gas formation, and bone growth were evaluated for both implantation sites and each bone region independently. Additionally, histological analysis of bone growth was performed on embedded hard-tissue samples. We demonstrate that in all cases, the degradation rate of ZX00-implants ranges between 0.23-0.75 mm/year. The highest degradation rates were found in the epiphysis. Bone-to-implant-contact varied between the time points and bone types for both materials. Mostly, bone-volume-to-total-volume was higher around Ti-implants. However, we found an increased cortical thickness around the ZX00-screws when compared to the Ti-screws. Our results showed the suitability of ZX00-screws for implantation into the distal meta- and epiphysis.

show abstract

“…The DRs calculated for both implantation sites accounted 0.23–0.75 mm/year. This lies within the range of DRs of different Mg alloys found in the literature [ 30 , 31 ]. Chaya et al .…”

Section: Discussionsupporting

confidence: 82%

Degradation behavior and osseointegration of Mg–Zn–Ca screws in different bone regions of growing sheep: a pilot study

Marek

Ćwieka

Donohue

et al. 2022

Regenerative Biomaterials

View full text Add to dashboard Cite

show abstract

“…29,76 Afterward, continuous surface modification of K-MET was further performed to achieve optimal degradation rates without damaging the growth plate. 77 3.3.3. In Japan.…”

Section: In South Koreamentioning

confidence: 99%

Application and Perspectives: Magnesium Materials in Bone Regeneration

Zhou,

Zhang,

et al. 2024

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

The field of bone regeneration has always been a hot and difficult research area, and there is no perfect strategy at present. As a new type of biodegradable material, magnesium alloys have excellent mechanical properties and bone promoting ability. Compared with other inert metals, magnesium alloys have significant advantages and broad application prospects in the field of bone regeneration. By searching the official Web sites and databases of various funds, this paper summarizes the research status of magnesium composites in the field of bone regeneration and introduces the latest scientific research achievements and clinical transformations of scholars in various countries and regions, such as improving the corrosion resistance of magnesium alloys by adding coatings. Finally, this paper points out the current problems and challenges, aiming to provide ideas and help for the development of new strategies for the treatment of bone defects and fractures.

show abstract

“…The concentrations of Mg 2 +, Ca 2 +, and Zn 2 + in local tissues were maintained within normal ranges during the degradation of Mg-Ca-Zn alloys. 162 In animal experiments, PEO-coated Mg-Ca-Zn alloy scaffold were implanted into the rabbit growth plate defects. The results showed that the implants did not cause significant immune response after implantation.…”

Section: Syntheticmentioning

confidence: 99%

Tissue engineering in growth plate cartilage regeneration: Mechanisms to therapeutic strategies

et al. 2023

View full text Add to dashboard Cite

The repair of growth plate injuries is a highly complex process that involves precise spatiotemporal regulation of multiple cell types. While significant progress has been made in understanding the pathological mechanisms underlying growth plate injuries, effectively regulating this process to regenerate the injured growth plate cartilage remains a challenge. Tissue engineering technology has emerged as a promising therapeutic approach for achieving tissue regeneration through the use of functional biological materials, seed cells and biological factors, and it is now widely applied to the regeneration of bone and cartilage. However, due to the unique structure and function of growth plate cartilage, distinct strategies are required for effective regeneration. Thus, this review provides an overview of current research on the application of tissue engineering to promote growth plate regeneration. It aims to elucidates the underlying mechanisms by which tissue engineering promotes growth plate regeneration and to provide novel insights and therapeutic strategies for future research on the regeneration of growth plate.

show abstract

In Vivo Response of Growth Plate to Biodegradable Mg-Ca-Zn Alloys Depending on the Surface Modification

Cited by 12 publications

References 33 publications

Degradation behavior and osseointegration of Mg–Zn–Ca screws in different bone regions of growing sheep: a pilot study

Degradation behavior and osseointegration of Mg–Zn–Ca screws in different bone regions of growing sheep: a pilot study

Application and Perspectives: Magnesium Materials in Bone Regeneration

Tissue engineering in growth plate cartilage regeneration: Mechanisms to therapeutic strategies

Contact Info

Product

Resources

About