In vivo rescue of genetic dilated cardiomyopathy by systemic delivery of nexilin
Yanjiao Shao,
Canzhao Liu,
Hsin-Kai Liao
et al.
Abstract:Background
Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Multiple identified mutations in nexilin (NEXN) have been suggested to be linked with severe DCM. However, the exact association between multiple mutations of Nexn and DCM remains unclear. Moreover, it is critical for the development of precise and effective therapeutics in treatments of DCM.
Results
In our study, Nexn global knockout mice and mice carrying h… Show more
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