In vivo relation of intramyocardial blood volume to myocardial perfusion. Evidence supporting microvascular site for autoregulation.

Abstract

We conclude that the FMB/F relation reflects hemodynamic conductance at the microvascular level.

Noninvasive Assessment of Myocardial Perfusion

“…Methods for correcting for this effect have been applied. 86 In terms of safety, the major concern is contrast-induced nephropathy, especially in patients with reduced renal function (creatinine clearance Ͻ60). 87…”

A magnetization‐driven gradient echo pulse sequence for the study of myocardial perfusion

“…Thus, a pulse sequence for which myocardial image intensity is linearly related to 1/T 1 would allow estimation of contrast agent mean transit times directly from image intensities without actually calculating contrast concentration (4,13). Furthermore, if a similar linear relationship exists in blood, regional myocardial blood volume can also be estimated (13)(14)(15) and combined with the mean transit time to allow quantification of regional myocardial blood flow (4,13,15).…”

Assessment of Cardiac Computed TomographyMyocardial Perfusion Imaging

“…Given that iodinated contrast is a diffusible tracer and its concentration in the extracellular space is known to increase over a period of time, it is crucial to image myocardial perfusion early during the firstpass circulation or apply mathematical models that take into account the extravascular diffusion of tracer. 30, 31 The relationship between CT attenuation number and iodine concentration can be altered by a number of factors such as beam hardening, and motion and reconstruction artifacts. Advances in temporal resolution, beam hardening correction, and reconstruction methods are designed to overcome these problems.…”