In vivo reflectance-mode confocal microscopy provides insights in human skin microcirculation and histomorphology

Altintas, M.A.; Meyer-Marcotty, Max; Altıntaş, Ahmet; Guggenheim, Merlin; Gohritz, Andreas; Aust, Matthias; Vogt, Peter M.

doi:10.1016/j.compmedimag.2009.04.011

Cited by 8 publications

(9 citation statements)

References 20 publications

(33 reference statements)

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“…With regard to the lateral resolution, CLSM is superior to conventional OCT and HFUS scanners. However, its penetration depth is limited to the papillary dermis 10,11 …”

mentioning

confidence: 99%

“…However, its penetration depth is limited to the papillary dermis. 10,11 The use of the aforementioned noninvasive techniques allows the researcher to gain qualitative and quantitative information about the tissue in real-time, otherwise not available. [2][3][4][5][6][7][8][9][10][11] We wondered whether noninvasive high resolution imaging techniques are suitable for the visualization of morphological alterations in the skin of MDE patients.…”

mentioning

confidence: 99%

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Non-invasive imaging of mid-dermal elastolysis

Scola

Goulioumis

Gambichler

2011

Clinical and Experimental Dermatology

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Mid-dermal elastolysis (MDE) is a rare disease that is characterized histopathologically by selective loss of elastic tissue in the mid dermis. We aimed to assess MDE using noninvasive skin imaging techniques in vivo. We examined both the lesional and adjacent healthy skin of a woman with the reticular variant of MDE, using confocal scanning laser microscopy, optical coherence tomography (OCT) and high-frequency ultrasound (HFUS). The median diameter of blood vessels at the top of dermal papillae was significantly increased in erythematous lesional skin compared with healthy skin. The mid-dermal signal intensity detected by OCT was higher in healthy skin than in lesional skin. With HFUS, mid-dermal density values were significantly higher in healthy skin than in lesional skin. Our preliminary findings indicate that noninvasive skin imaging methods such as OCT and HFUS might be suitable techniques for the evaluation and monitoring of elastolytic skin disorders such as MDE.

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“…With regard to the lateral resolution, CLSM is superior to conventional OCT and HFUS scanners. However, its penetration depth is limited to the papillary dermis 10,11 …”

mentioning

confidence: 99%

mentioning

confidence: 99%

Non-invasive imaging of mid-dermal elastolysis

Scola

Goulioumis

Gambichler

2011

Clinical and Experimental Dermatology

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“…IVCM is a new in vivo transcutaneous imaging method to study cutaneous microcirculation. It is non‐invasive and allows observing the capillary flow and imaging the tissue under observation, evaluating parameters like skin thickness, epidermal cell size, number of capillaries/mm 2 , size, shape, and depth of the microvessels .…”

Section: Discussionmentioning

confidence: 99%

“…IVCM has a high resolution and allows imaging the skin and the dermal capillaries and observing blood flow in real time. Several studies demonstrate its utility to evaluate the cutaneous microcirculation such as in flap donor sites , in flap follow‐up after surgery , in burn shock patients , in human burn wound healing , in local superficial burns , and after temperature changes .…”

Section: Discussionmentioning

confidence: 99%

Quantification of capillary blood cell flow using reflectance confocal microscopy

Cinotti

Gergelé

Perrot

et al. 2014

Skin Research and Technology

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“…These changes reflect a significant improvement in the quality of the dermal–epidermal junction and are consistent with the results of other clinical studies based on conventional histology. They noted in addition an increased depth of the collagen refringence band (9.7 ± 5.0 [9.7%] at 3 months and 6.3 ± 8.6 [5.18%] at 9 months) a clear evidence to long‐term collagen remodeling …”

Section: Basic Science Researchmentioning

confidence: 99%

Painless, safe, and efficacious noninvasive skin tightening, body contouring, and cellulite reduction using multisource 3DEEP radiofrequency

Harth

2015

J of Cosmetic Dermatology

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In the last decade, Radiofrequency (RF) energy has proven to be safe and highly efficacious for face and neck skin tightening, body contouring, and cellulite reduction. In contrast to first-generation Monopolar/Bipolar and "X -Polar" RF systems which use one RF generator connected to one or more skin electrodes, multisource radiofrequency devices use six independent RF generators allowing efficient dermal heating to 52-55°C, with no pain or risk of other side effects. In this review, the basic science and clinical results of body contouring and cellulite treatment using multisource radiofrequency system (Endymed PRO, Endymed, Cesarea, Israel) will be discussed and analyzed.

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In vivo reflectance-mode confocal microscopy provides insights in human skin microcirculation and histomorphology

Cited by 8 publications

References 20 publications

Non-invasive imaging of mid-dermal elastolysis

Non-invasive imaging of mid-dermal elastolysis

Quantification of capillary blood cell flow using reflectance confocal microscopy

Painless, safe, and efficacious noninvasive skin tightening, body contouring, and cellulite reduction using multisource 3DEEP radiofrequency

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