In vivo real-time imaging of airway dynamics during bronchial challenge test

Hwang, Sang Seok; Chae, Yu-Gyeong; Oak, Chulho; Jung, Jae-Chul; Lee, Hae Young; Kim, Sung Won; Chun, Bong Kwon; Kim, Hee-Kyoo; Jung, Maan Hong; Ahn, Yeh‐Chan; Park, Hae‐Sim

doi:10.1002/lsm.22345

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…There may be other, more direct and until now unrecognized indices of peripheral airway function that are causally related to aerosol particle generation. Their determination might include high resolution or optical computer tomograms at different levels of lung inflation as performed, for example, for bronchial provocation testing 18 . It might also be of interest to include subjects with airway diseases in order to cover a broader range of function and dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Indices of airway resistance and reactance from impulse oscillometry correlate with aerosol particle emission in different age groups

Schumm,

Bremer,

Knödlseder

et al. 2024

Sci Rep

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Airborne transmission of pathogens plays a major role in the spread of infectious diseases. Aerosol particle production from the lung is thought to occur in the peripheral airways. In the present study we investigated eighty lung-healthy subjects of two age groups (20–39, 60–76 years) at rest and during exercise whether lung function parameters indicative of peripheral airway function were correlated with individual differences in aerosol particle emission. Lung function comprised spirometry and impulse oscillometry during quiet breathing and an expiratory vital capacity manoeuvre, using resistance (R5) and reactance at 5 Hz (X5) as indicators potentially related to peripheral airway function. The association between emission at different ventilation rates relative to maximum ventilation and lung function was assessed by regression analysis. In multiple regression analyses including age group, only vital capacity manoeuvre R5 at 15% to 50% of end-expiratory vital capacity as well as quiet breathing X5 were independently linked to particle emission at 20% to 50% of maximum ventilation, in addition to age group. The fact that age as predictive factor was still significant, although to a lower degree, points towards further effects of age, potentially involving surface properties not accounted for by impulse oscillometry parameters.

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Section: Discussionmentioning

confidence: 99%

Indices of airway resistance and reactance from impulse oscillometry correlate with aerosol particle emission in different age groups

Schumm,

Bremer,

Knödlseder

et al. 2024

Sci Rep

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show abstract

“…The higher resolution of aOCT imaging can provide smoother reconstructions of airway surfaces that avoid these limitations. In addition, aOCT scans can provide dynamic airway data [4], [12], [13] without radiation exposure. Such data are needed to characterize soft-tissue changes for the development of fluidstructure interaction models [44] that can predict airway wall collapse and assess potential treatment outcomes.…”

Section: Discussionmentioning

confidence: 99%

Geometric Validation of Continuous, Finely Sampled 3-D Reconstructions From aOCT and CT in Upper Airway Models

Price

Kimbell

et al. 2019

IEEE Trans. Med. Imaging

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Identification and treatment of obstructive airway disorders (OADs) are greatly aided by imaging of the geometry of the airway lumen. Anatomical optical coherence tomography (aOCT) is a promising high-speed and minimally invasive endoscopic imaging modality for providing micrometer-resolution scans of the upper airway. Resistance to airflow in OADs is directly caused by the reduction in luminal cross-sectional area (CSA). It is hypothesized that aOCT can produce airway CSA measurements as accurate as that from computed tomography (CT). Scans of machine hollowed cylindrical tubes were used to develop methods for segmentation and measurement of airway lumen in CT and aOCT. Simulated scans of virtual cones were used to validate 3-D resampling and reconstruction methods in aOCT. Then, measurements of two segments of a 3-D printed pediatric airway phantom from aOCT and CT independently were compared to ground truth CSA. In continuous unobstructed regions, the mean CSA difference for each phantom segment was 2.2 ± 3.5 and 1.5 ± 5.3 mm 2 for aOCT, and −3.4 ± 4.3 and −1.9 ± 1.2 mm 2 for CT. Because of the similar magnitude of these differences, these results support the hypotheses and underscore the potential for aOCT as a viable alternative to CT in airway imaging, while offering greater potential to capture respiratory dynamics.

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In vivo real-time imaging of airway dynamics during bronchial challenge test

Cited by 2 publications

References 19 publications

Indices of airway resistance and reactance from impulse oscillometry correlate with aerosol particle emission in different age groups

Indices of airway resistance and reactance from impulse oscillometry correlate with aerosol particle emission in different age groups

Geometric Validation of Continuous, Finely Sampled 3-D Reconstructions From aOCT and CT in Upper Airway Models

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