In vivo Raman spectroscopic analysis of the influence of UV radiation on carotenoid antioxidant substance degradation of the human skin

Darvin, Maxim E.; Gersonde, Ingo; Albrecht, H.; Sterry, Wolfram; Lademann, Juergen

doi:10.1134/s1054660x06050148

Cited by 68 publications

(79 citation statements)

References 13 publications

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“…It has been widely reported that the irradiation of skin with UV light leads to the formation of free radicals, which can destroy the antioxidants of the skin, if the dosage is high enough [3,9,15,29] . Taking into consideration the energy of the UV photons, it is understandable that radical formation processes can be induced, although this it not the case for IR radiation.…”

Section: Discussionmentioning

confidence: 99%

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Radical Production by Infrared A Irradiation in Human Tissue

Darvin

Haag

Meinke

et al. 2010

Skin Pharmacol Physiol

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The influence of the ultraviolet (UV) irradiation of the sun on the formation of free radicals in human skin is well investigated. Up to now, only small amounts of data are available stating that infrared (IR) irradiation can produce free radicals in the skin. In the present study, the formation of free radicals in human skin, subsequent to IRA irradiation (600–1,500 nm), has been demonstrated by means of two different methods. Firstly, the radical formation was detected indirectly by the degradation of the cutaneous carotenoid antioxidants β-carotene and lycopene, which was investigated in vivo by resonance Raman spectroscopic measurements. Secondly, the direct observation of produced radicals subsequent to IRA irradiation of the skin was performed in vitro by electron paramagnetic resonance spectroscopy. Taking into account the results of the present study and previous UV light studies, it can be expected that also solar irradiation in the visible spectral range will produce free radicals in the human skin. Therefore, the current sun protection strategies should be reconsidered. Furthermore, it was shown in the present study that the side effect in the form of radical formation could be significantly reduced by increasing the protection system of the human organism in form of the antioxidant network.

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Section: Discussionmentioning

confidence: 99%

“…The observed degradation was explained by the interaction of the carotenoids with high amounts of free radicals produced in the skin, subsequent to UV irradiation [15] .…”

mentioning

confidence: 99%

Radical Production by Infrared A Irradiation in Human Tissue

Darvin

Haag

Meinke

et al. 2010

Skin Pharmacol Physiol

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“…14,15 The two most prominent carotenoids in the skin are beta-carotene and lycopene. 14 Studies have shown that ultraviolet radiation 16 and infrared radiation 17 reduce the concentration of carotenoids in the skin, presumably because the carotenoids are destroyed through their interaction with radiation-induced free radicals. Oxidative stress is associated with enhanced skin aging, 18 and conversely, skin with a high carotenoid concentration appears younger 14 and has fewer furrows and wrinkles than skin with a low carotenoid concentration.…”

Section: Introductionmentioning

confidence: 99%

Effect of beta-carotene supplementation on African skin

Coetzee

Perrett

2014

J. Biomed. Opt

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Abstract. The quantification of skin carotenoid levels has a range of applications in Caucasian populations, from serving as a versatile and noninvasive biomarker (e.g., of systemic carotenoid levels, carotenoid consumption, the antioxidative capacity of skin, and oxidative stress) to being used in appearance-based interventions. Yet, no study has investigated the quantitative effect of carotenoid supplementation on African skin. The aim of this study was to determine if beta-carotene supplementation produces a significant color change in three different regions of African skin. To do so we supplemented the diet of African participants with beta-carotene over an eight-week period. Reflectance spectrophotometry measurements were taken on a weekly basis for the duration of the supplementation study. Results show a significant increase in the carotenoid coloration of lightly pigmented skin (palm of the hand) and highly pigmented skin with low sun exposure (inner arm) after supplementation. The latter was no longer significant after Bonferroni correction. The carotenoid coloration of highly pigmented skin areas with high sun exposure did not increase significantly. Skin carotenoid measurements of the palm of the hand might, therefore, serve as a potential biomarker for systemic carotenoid concentrations in people of African descent.

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“…UV light leads to the formation of highly reactive free radicals in the skin [29,30,31] and sufficient amounts of antioxidants are required to neutralize these [32]. An adequate neutralization cannot be performed if the concentration of the antioxidants has already decreased on account of alcohol consumption.…”

Section: Introductionmentioning

confidence: 99%

Alcohol Consumption Decreases the Protection Efficiency of the Antioxidant Network and Increases the Risk of Sunburn in Human Skin

Darvin

Sterry

Lademann

et al. 2012

Skin Pharmacol Physiol

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In recent years, epidemiological data has demonstrated that alcohol consumption is a risk factor for sunburn, melanoma and nonmelanoma skin cancer. We hypothesized that if the concentration of the antioxidants in the skin has already decreased due to alcohol consumption, then an adequate neutralization of the free radicals induced by ultraviolet light cannot be performed. Based on this hypothesis, we determined the carotenoid concentration in the skin and the minimal erythema dose (MED) of 6 male human volunteers before and after consumption of alcohol or alcohol and orange juice combined. The results showed a significant decrease in the carotenoid concentration in the skin and the MED after alcohol consumption, but no significant decrease after a combined intake of alcohol and orange juice.

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In vivo Raman spectroscopic analysis of the influence of UV radiation on carotenoid antioxidant substance degradation of the human skin

Cited by 68 publications

References 13 publications

Radical Production by Infrared A Irradiation in Human Tissue

Radical Production by Infrared A Irradiation in Human Tissue

Effect of beta-carotene supplementation on African skin

Alcohol Consumption Decreases the Protection Efficiency of the Antioxidant Network and Increases the Risk of Sunburn in Human Skin

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