In vivo quantification of the limbic system using MRI: Effects of normal aging

LIM, K; Zipursky, Robert B.; MURPHYJR, G; Pfefferbaum, A.

doi:10.1016/s0165-1781(06)80004-1

Cited by 16 publications

(26 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is similar to what has been reported in some previous studies (Lim et al, 1990, Convit et al, 1995, De Leon et al, 1997, Jernigan et al, 2001, Scahill et al, 2003, Raz et al, 2004a, Raz et al, 2004b, Du et al, 2006. However, after normalization the relationships were no longer significant.…”

Section: Volumetric Losssupporting

confidence: 92%

“…One of the major factors associated with hippocampal changes is age. The age association has been demonstrated in several studies with cross-sectional (Lim et al, 1990, Coffey et al, 1992, Pfefferbaum et al, 1994, Sullivan et al, 1995, De Leon et al, 1997, Schuff et al, 1999, Jernigan et al, 2001, Scahill et al, 2003, Sullivan et al, 2005 and longitudinal (Jack et al, 1998, Scahill et al, 2003, Raz et al, 2004b, Du et al, 2006 designs. Recent research based on magnetic resonance imaging (MRI) has also demonstrated that a spatial mapping method could enhance the detection of the subtle changes in volumetric information and the understanding of age effects on specific regions of hippocampi (Janke et al, 2001, Wang et al, 2003, Thompson et al, 2004, Chetelat et al, 2005.…”

Section: Introductionmentioning

confidence: 84%

“…However, these findings in healthy subjects have been inconsistent. Some studies revealed that age was not significantly related to the volume reduction of the hippocampus (Sullivan et al, 1995, Sullivan et al, 2005; others obtained the opposite results (Lim et al, 1990, Convit et al, 1995, De Leon et al, 1997, Jernigan et al, 2001, Scahill et al, 2003, Raz et al, 2004a, Raz et al, 2004b, Du et al, 2006. The discrepancies in the results of these reports might be due to differences in the segmentation of anatomical regions, or in the age range of the subjects studied.…”

Section: Introductionmentioning

confidence: 92%

“…In addition to treating age as a matching factor, many studies have analyzed the effect of aging on the volume of the hippocampus (Lim et al, 1990, Convit et al, 1995, Sullivan et al, 1995, De Leon et al, 1997, Jernigan et al, 2001, Scahill et al, 2003, Raz et al, 2004a, Raz et al, 2004b, Sullivan et al, 2005, Du et al, 2006. However, these findings in healthy subjects have been inconsistent.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Age effects on hippocampal structural changes in old men: The HAAS

Valentino

Scher

et al. 2008

NeuroImage

View full text Add to dashboard Cite

Understanding the variability of the hippocampus in human brain research is essential. The effect of age on the hippocampus has been explored in several studies that have been focused on either normal aging or neural degeneration. Shape analysis of magnetic resonance imaging (MRI) provides morphological measures for brain structures. This study further investigates the age effects on hippocampal morphology in three groups (104 normal controls, 24 Alzheimer's disease (AD) and 14 vascular dementia (VaD) patients). By utilizing a parametric shape analysis of hippocampal MRI scans, each individual distance map is generated and analyzed statistically. Specifically, after eliminating similarity parameters (rotation, translation, and scaling) effects for each hippocampus, an individual distance map is generated from parametric hippocampal surfaces and medial axes. Then statistical methods, including regression, and permutation tests, are applied to detect the differences in hippocampal distance maps and volumes under the effect of age in each group. Statistical analyses reveal that the loss of hippocampal volume and changes in shape are more significantly related to aging in the control group than in AD/VaD. The results also show that the asymmetry of hippocampus in healthy subjects is greater than that in either of the disease groups. Our study shows that 3D statistical shape analysis could enhance the understanding of age effects on local areas of hippocampi. However, the sample sizes of disease groups are relatively low; further studies with more AD/VaD data are needed.

show abstract

Section: Volumetric Losssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Age effects on hippocampal structural changes in old men: The HAAS

Valentino

Scher

et al. 2008

NeuroImage

View full text Add to dashboard Cite

show abstract

“…Several authors have reported similar age-related volume decreases in these regions [8,9,12,18,26,31]. However, other authors have failed to find such a decline in medial temporal lobe volumes [24,31,37]. Linear increases with advancing age were found for the volume of the third ventricle (taken as an index for atrophy of the dorsomedial thalamus [19]).…”

Section: Normal Brain Agingmentioning

confidence: 92%

The relation between global and limbic brain volumes on MRI and cognitive performance in healthy individuals across the age range

Tisserand

Visser

Boxtel

et al. 2000

Neurobiology of Aging

118

View full text Add to dashboard Cite

The present study investigated the range of age-related changes in brain morphology and the relation with performance on memory and other cognitive tests in a healthy population. A group of 61 subjects (21 to 81 years old, mean ϭ 55.7), free from cognitive and medical deficits, underwent MRI scanning and neuropsychological assessment encompassing memory and other cognitive tests. Volumetry of the hippocampus, parahippocampal gyrus, mamillary bodies, third ventricle, and total brain matter was performed. The results indicate that in healthy individuals increases in ventricular volume and volume decreases in total brain matter, hippocampus and parahippocampal gyrus, but not mamillary bodies, are clearly apparent with increasing age. However, no relation could be established between the brain volumes and test performance when controlling for the effects of age. To conclude, variations in total and limbic brain volumes do not seem predictive for cognitive performance independent of age.

show abstract