In vivo quantification of lumbar disc degeneration: assessment of ADC value using a degenerative scoring system based on Pfirrmann framework

Yu, Hua; Bahri, Shadfar; Gardner, Vance O.; Muftuler, L. Tugan

doi:10.1007/s00586-014-3721-0

Cited by 26 publications

(22 citation statements)

References 20 publications

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“…Third, although results of some advanced imaging techniques such as T1ρ, chemical exchange saturation transfer, ultra-short TE, or apparent diffusion coefficient, were not compared with those of T2 ∗ relaxation time, several studies verified the usefulness of this technique alone to diagnose IVDD. [18,26–28] Fourth, the sample size in the present study, especially after further grade or age classification, was not adequate. Multicenter studies with larger sample sizes, more rigorous designs, and evidence-based reviews should be conducted.…”

Section: Discussionmentioning

confidence: 78%

Correlation between T2* (T2 star) relaxation time and cervical intervertebral disc degeneration

Huang

Guo

et al. 2016

Medicine

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Purpose:To demonstrate the potential benefits of T2∗ relaxation time of intervertebral discs (IVDs) regarding the detection and grading of degenerative disc disease using 3.0-T magnetic resonance imaging (MRI) in a clinical setting.Materials and Methods:Cervical sagittal T2-weighted, T2∗ relaxation MRI was performed at 3.0-T in 61 subjects, covering discs C2–3 to C6–7. All discs were morphologically assessed based on the Pfirrmann grade, and regions of interests (ROIs) were drawn over the T2∗ mapping. Receiver operating characteristic (ROC) analysis was performed among grades to determine the cut-off values.Results:Cervical intervertebral discs (IVDs) of patients were commonly determined to be at Pfirrmann grades III to V. The nucleus pulposus (NP) values did not differ significantly between sexes at the same anatomic level (P > 0.05). In the NP, the T2∗ values tended to decrease with increasing grade (P < 0.000), and a significant difference was found in the T2 values between grades I to V (P < 0.05). T2∗ values based on disc degeneration level classification were as follows: grade I (>30 milliseconds), grade II (24.55–29.99 milliseconds), grade III (21.65–24.54 milliseconds), grade IV (18.35–21.64 milliseconds), and grade V (<18.34 milliseconds).Conclusion:Our standardized method of region-specific quantitative T2∗ relaxation time evaluation seems capable of characterizing different degrees of disc degeneration quantitatively. The T2∗ values obtained in these cervical IVDs may serve as baseline values for future T2∗ measurements in both healthy and degenerated cervical discs.

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Section: Discussionmentioning

confidence: 78%

Correlation between T2* (T2 star) relaxation time and cervical intervertebral disc degeneration

Huang

Guo

et al. 2016

Medicine

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“…In connection with this, a detailed preoperative examination of patients is necessary, taking into account modern neuroimaging methods of examination. 21,22 When analyzing the specialized literature, we did not observe any fundamental differences in the clinical outcomes of VAS and ODI in each of the surgical correction groups. 3,7,8 At the same time, in this study, lower indicators for the level of pain in the lumbar and lower limbs and quality of life by ODI were determined in a group of patients operated with the application of artificial IVD M-6.…”

Section: Discussionmentioning

confidence: 75%

Analysis of Postoperative Outcomes of Degenerative Diseases of the Lumbosacral Junction

et al. 2018

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Objective: The article presents an analysis of the clinical efficacy and causes of unsatisfactory outcomes of surgical treatment in patients with degenerative diseases of the lumbosacral junction of the spine. Methods: Patients were allocated to one of three groups, depending on the method of surgical intervention on the lumbosacral junction: 1) (n=352) - operated by the method of microsurgical discectomy; 2) (n=83) - operated with the use of artificial IVD prostheses; 3) (n = 183) - operated with the use of interbody fusion and posterior rigid stabilization. To investigate the causes of unsatisfactory outcomes, a correlation analysis was conducted of long-term clinical outcomes with preoperative instrumental parameters in the operated segment, surgical tactics used, and the development of complications. Results: It is determined that long-term “good” clinical outcomes are associated with individual preoperative parameters of the lumbosacral junction of the spine - linear displacement, sagittal angulation, height of the interbody space, degree of IVD degeneration by ADC. Conclusion: In degenerative diseases of the lumbosacral junction of the spine, the detailed analysis of long-term clinical outcomes enable the identification of the causes that affect the development of unsatisfactory outcomes, which are individual morphostructural changes in the lower lumbar segment: the amplitude of the segmental angle, the angle of the lumbar lordosis, the degree of linear displacement of the vertebrae, the height of the interbody space, and ADC. Complex clinical and instrumental analysis enabled us to determine possible surgical tactics. Level of Evidence II; Prognostic Studies— Investigating the Effect of a Patient Characteristic on the Disease Outcome.

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“…One of the primary causes for low back and neck pain is intervertebral disc degeneration . In an effort to reduce these societal costs, research is focusing on techniques to identify early signs of disc degeneration so preventative treatments can be initiated before symptoms become disabling and costly.…”

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confidence: 99%

Dynamic functional nucleus is a potential biomarker for structural degeneration in cervical spine discs

LeVasseur

Wawrose

Pitcairn

et al. 2019

Journal Orthopaedic Research

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If intervertebral disc degeneration can be identified early, preventative treatments may be initiated before symptoms become disabling and costly. Changes in disc mechanics, such as the decrease in the compressive modulus of the nucleus, are some of the earliest signs of degeneration. Therefore, in vivo changes in the disc response to compressive load may serve as a biomarker for pending or early disc degeneration. The aim of this study was to assess the potential for using in vivo dynamic disc deformation to identify pathologic structural degeneration of the intervertebral disc. A validated model‐based tracking technique determined vertebral motion from biplane radiographs collected during dynamic flexion/extension and axial rotation of the cervical spine. A computational model of the subaxial intervertebral discs was developed to identify the dynamic functional nucleus of each disc, that is, the disc region that underwent little to no additional compression during dynamic movements. The size and location of the dynamic functional nucleus was determined for 10 C5/C6 spondylosis patients, 10 C5/C6/C7 spondylosis patients, and 10 asymptomatic controls. The dynamic functional nucleus size was sensitive (significantly smaller than controls in 5 of 6 measurements at the diseased disc) and specific (no difference from controls in 9 of 10 measurements at non‐diseased discs) to pathologic disc degeneration. These results provide evidence to suggest that structural disc degeneration, manifested by changes in the disc response to functional loading, may be identified in vivo from dynamic imaging collected during functional movements. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 9999:1–7, 2019.

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In vivo quantification of lumbar disc degeneration: assessment of ADC value using a degenerative scoring system based on Pfirrmann framework

Cited by 26 publications

References 20 publications

Correlation between T2* (T2 star) relaxation time and cervical intervertebral disc degeneration

Correlation between T2* (T2 star) relaxation time and cervical intervertebral disc degeneration

Analysis of Postoperative Outcomes of Degenerative Diseases of the Lumbosacral Junction

Dynamic functional nucleus is a potential biomarker for structural degeneration in cervical spine discs

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