In vivo pulsatile LHRH release into the anterior pituitary of the male rat: effects of castration

Phelps, Christopher; Kalra, Satya P.; Kalra, Pushpa S.

doi:10.1016/0006-8993(92)90384-l

Cited by 11 publications

(2 citation statements)

References 19 publications

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“…Castration has been reported to increase both the frequency and the amplitude of GnRH pulses Grattan et al, 1995) (Fig. 6), to increase the frequency but not the amplitude (Meredith and Levine, 1992), or to have no significant effect on GnRH secretion (Phelps et al, 1992). The substantial technical demands of these methods (animal and assay), particularly in a small mammal like the rat, is a likely cause for these literature discrepancies.…”

Section: Do Gnrh Mrna Levels Reflect Gnrh Biosynthesis And/or Releasementioning

confidence: 97%

Hormonal and neurotransmitter regulation of GnRH gene expression and related reproductive behaviors

et al. 1996

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Gonadotropin-releasing hormone (GnRH), having a highly conserved structure across mammalian species, plays a pivotal role in the control of the neuroendocrine events and the inherent sexual behaviors essential for reproductive function. Recent advances in molecular genetic technology have contributed greatly to the investigation of several aspects of GnRH physiology, particularly steroid hormone and neurotransmitter regulation of GnRH gene expression. Behavioral studies have focused on the actions of GnRH in steroid-sensitive brain regions to understand better its role in the facilitation of mating behavior. To date, however, there are no published reports which directly correlate GnRH gene expression and reproductive behavior. The intent of this article is to review the current understanding of the way in which changes in GnRH gene expression, and modifications of GnRH neuronal activity, may ultimately influence reproductive behavior.

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Section: Do Gnrh Mrna Levels Reflect Gnrh Biosynthesis And/or Releasementioning

confidence: 97%

Hormonal and neurotransmitter regulation of GnRH gene expression and related reproductive behaviors

et al. 1996

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“…GnRH release (Caraty and Locatelli, 1988; Clarke et al, 1987; Gore et al, 2004; Grattan et al, 1995; Levine and Ramirez, 1982; Meredith and Levine, 1992; Moenter et al, 1991; Phelps et al, 1992; Ramirez et al, 1991) and LH (Alexander and Irvine, 1987; Ar, 1985; Backstrom et al, 1982; Ben Jebara et al, 1994; Caraty and Locatelli, 1988; Czieselsky et al, 2016; Ellis and Desjardins, 1984; Evans et al, 1979; Ginther et al, 1998; Hodges, 1978; Irvine and Alexander, 1994; Jain et al, 2007; Joustra et al, 2016; Levine and Ramirez, 1982; Luboshitzky et al, 1996; Matsumoto and Bremner, 1984; Mulligan et al, 1995; Nordéus et al, 2012; Rossmanith et al, 1990b; Sisk and Desjardins, 1986; Soules et al, 1988, 1989; Steiner et al, 1982; Urban et al, 1988; van Leckwyck et al, 2016; Veldhuis et al, 1988; Vugt et al, 1984; Wu et al, 1996) oscillates with τ = ~ 1 to 4 h in both sexes, and these pulses are consistently coupled, within minutes within individuals (Alexander and Irvine, 1987; Bergendahl et al, 1996; Caraty et al, 1992; Caraty and Locatelli, 1988; Chandolia et al, 1997; Gazal et al, 1998; Irvine and Alexander, 1994; Levine and Ramirez, 1982). FSH exhibits low-amplitude URs that are often concomitant with LH (Booth et al, 1996; Genazzani et al, 1993; Joustra et al, 2016; Lockwo...…”

Section: Urs and Coupling Within Endocrine Axesmentioning

confidence: 99%

Evidence for a Coupled Oscillator Model of Endocrine Ultradian Rhythms

et al. 2018

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Whereas long-period temporal structures in endocrine dynamics have been well studied, endocrine rhythms on the scale of hours are relatively unexplored. The study of these ultradian rhythms (URs) has remained nascent, in part, because a theoretical framework unifying ultradian patterns across systems has not been established. The present overview proposes a conceptual coupled oscillator network model of URs in which oscillating hormonal outputs, or nodes, are connected by edges representing the strength of node-node coupling. We propose that variable-strength coupling exists both within and across classic hormonal axes. Because coupled oscillators synchronize, such a model implies that changes across hormonal systems could be inferred by surveying accessible nodes in the network. This implication would at once simplify the study of URs and open new avenues of exploration into conditions affecting coupling. In support of this proposed framework, we review mammalian evidence for (1) URs of the gut-brain axis and the hypothalamo-pituitary-thyroid, -adrenal, and -gonadal axes, (2) UR coupling within and across these axes; and (3) the relation of these URs to body temperature. URs across these systems exhibit behavior broadly consistent with a coupled oscillator network, maintaining both consistent URs and coupling within and across axes. This model may aid the exploration of mammalian physiology at high temporal resolution and improve the understanding of endocrine system dynamics within individuals.

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Molecular biology of the regulation of hypothalamic hormones

Rondeel

Jackson

1993

J Endocrinol Invest

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In vivo pulsatile LHRH release into the anterior pituitary of the male rat: effects of castration

Cited by 11 publications

References 19 publications

Hormonal and neurotransmitter regulation of GnRH gene expression and related reproductive behaviors

Hormonal and neurotransmitter regulation of GnRH gene expression and related reproductive behaviors

Evidence for a Coupled Oscillator Model of Endocrine Ultradian Rhythms

Molecular biology of the regulation of hypothalamic hormones

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