In - vivo proton spin lattice relaxation times in normal and dystrophic muscles

Narayana, Ponnada A.; Delayre, Jean L.; Misra, Lalith K.

doi:10.1016/0730-725x(86)90903-3

Cited by 1 publication

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“…Measurements of relaxation times have been used to discriminate muscle in patients with Duchenne muscular dystrophy from muscle in healthy controls. 11,18 To our knowledge, the same study has not been undertaken in the brain of patients with Duchenne dystrophy. The T2 values in muscle change with progression of the disease in humans, indicating that they can be used to follow both progression and therapy.…”

Section: Discussionmentioning

confidence: 99%

“…The T1 relaxation time has been shown to be significantly higher in dystrophic chicken muscle than in the control. 17,18 In patients with Duchenne muscular dystrophy, T1 is initially higher than controls and decreases to a value lower than controls. The elevated T1 in younger individuals has been attributed to higher water content 16 and the reduction with age correlates with increased muscle fat content.…”

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confidence: 99%

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Quantitative magnetic resonance imaging of the mdx mouse model of Duchenne muscular dystrophy

Dunn

Wadghiri

1999

Muscle Nerve

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The mdx mouse has a genetically homologous disease to Duchenne muscular dystrophy in humans. The disease progression, however, is not accompanied by the same level of fatty infiltration and muscle degeneration as occurs in humans. Thus, the presence of histological/ pathological changes in living mdx mice has been difficult to monitor. We quantified proton density and the T2 relaxation time of protons with a resolution of 195 × 195 × 1000 µm using multiecho magnetic resonance (MR) imaging at 7 Tesla. These relaxation data were correlated with water content in both muscle and brain of mdx and controls. No differences were observed in brain. The mdx muscles had increased water content and proton density and decreased T2 relative to controls. These data indicate that there are intrinsic changes in T2 (opposite to that which would be induced by fatty infiltration) and suggest that T2 imaging could be used to monitor progression and treatment in this animal model.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%