In Vivo Proton Relaxation Times Analysis of the Skin Layers by Magnetic Resonance Imaging

Richard, Stéphanie; Querleux, Bernard; Bittoun, J.; Idy-Peretti, I.; Jolivet, Odile; Čermáková, Eva; Lévêque, Jean-Luc

doi:10.1111/1523-1747.ep12478540

Cited by 106 publications

(85 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, other report showed that a fast repetition caused saturation but provided high T1 contrast [10].…”

Section: Discussionmentioning

confidence: 91%

“…In clinical imaging, the main challenge is still how to distinguish different characteristics of skin components such as semisolid glycolipids, hair root, oil-rich sebaceous glands and active epidermis viable layer with limited success using different clinical MRI techniques as listed in Table 1 [2][3][4][5][6][7][8][9][10][11][12].…”

Section: Skin Mri Imagingmentioning

confidence: 99%

“…In vivo proton relaxation times analysis by MRI (skin layers) 1.5 [9] 9. In vivo high-resolution MRI (skin in a whole-body system) 1.5 [10] 10. In vivo MR microscopy by customized 3D gradient and partial flip-angle using spin-echo pulse sequences and very small transmit/receive coils (human skin structures) 1.5 [11] 11.…”

Section: Phantom Imagingmentioning

confidence: 99%

“…However, total imaging time was reduced by a factor of 10 to achieve steady-state condition. The total imaging time in the previous study was 60 min using TR=4000 ms [10].…”

Section: Mri-histology Comparisonmentioning

confidence: 99%

See 3 more Smart Citations

Microimaging of hairless rat skin by magnetic resonance at 900 MHz

Sharma

2009

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Purpose: Quantitative imaging of the rat skin was performed using magnetic resonance imaging (MRI) at 900 MHz. Materials and methods: A number of imaging techniques utilized for multiple contrast included magnetization transfer contrast, spin-lattice relaxation constant (T1-weighting), combination of T2-weighting with magnetic field inhomogeneity (T2*-weighting), magnetization transfer weighting and diffusion tensor weighting. These were used to obtain 2D slices and 3D multislice-multiecho images with high magnetic resonance contrast. These 2D and 3D imaging techniques were combined to achieve high-resolution MRI. Results: Oil-water phantom showed distinct fat-water contrast. The dermis and epidermis, including the stratum corneum remnants, of nude rat skin were distinct due to their proton magnetic resonance as a result of proton interactions with the skin interstitial tissue. Combined details obtained from high-resolution, high-quality ex vivo skin images with different multicontrast characteristics generated better differentiation of skin layers, sublayers and significant correlation (r 2 =0.4927 for MRI area, r 2 =0.3068 for histology area; Pb.0148) of MR data with co-registered histological areas of the epidermis as well as the hair follicle. Conclusion: The multiple contrast approach provided a noninvasive ex vivo MRI visualization with semi-quantitative assessment of the major skin structures including the stratum corneum remnants, epidermis, hair, papillary dermis, reticular dermis and hypodermis.

show abstract

“…However, other report showed that a fast repetition caused saturation but provided high T1 contrast [10].…”

Section: Discussionmentioning

confidence: 91%

Section: Skin Mri Imagingmentioning

confidence: 99%

Section: Phantom Imagingmentioning

confidence: 99%

“…However, total imaging time was reduced by a factor of 10 to achieve steady-state condition. The total imaging time in the previous study was 60 min using TR=4000 ms [10].…”

Section: Mri-histology Comparisonmentioning

confidence: 99%

See 2 more Smart Citations

Microimaging of hairless rat skin by magnetic resonance at 900 MHz

Sharma

2009

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…The first MR microimages of skin layers-epidermis, dermis, and hypodermis-were published by Bittoun et al (1). Their success was accomplished thanks to the home-made construction of a high-resolution imaging module consisting of a small radiofrequency (RF) coil and gradient surface coils (3)(4)(5). With standard two-or three-dimensional (2D, 3D) gradient or spin-echo pulse sequences, they were able to achieve an in vivo resolution of 59 ϫ 118 ϫ 600 m 3 (8).…”

mentioning

confidence: 99%