In Vivo Platelet Activation in Critically Ill Patients With Primary 2009 Influenza A(H1N1)

Abstract

These findings, derived from a small but documented cohort of patients, demonstrate that platelet activation responses during A(H1N1) are enhanced-exceeding responses in patients with bacterial pneumonia-and provide new evidence that platelets may contribute to inflammatory responses during A(H1N1).

VTE Incidence and Risk Factors in Patients With Severe Sepsis and Septic Shock

“…Th ese dysregulated responses include cellular activation responses, deposition of platelet-fi brin thrombi within the vasculature, and the development of disseminated intravascular coagulation. 12,[17][18][19][20][21][22] Th ese and other factors lead to hypercoagulability and may explain, in part, the high incidence of VTE in patients with sepsis identifi ed in the current study.…”

Influenza virus H1N1 activates platelets through FcγRIIA signaling and thrombin generation

“…Platelets are an important source of inflammatory mediators, which are either stored or can be produced de novo upon activation. 3,4 Intrigued by the presence of activated platelets in the blood of critically ill influenza H 1 N 1 infected patients, [33][34][35]37 we aimed to study the activation of platelets by the H 1 N 1 IAV.…”

Emerging roles for platelets as immune and inflammatory cells

“…162 Platelet activation in H1N1A infection exceeded platelet activation noted in bacterial pneumonia. 163 Similar to HIV infection, platelet-monocyte aggregates are elevated in influenza infection suggesting that platelets affect viral immune responses. 163 Many of these important associations are only beginning to be identified.…”

“…163 Similar to HIV infection, platelet-monocyte aggregates are elevated in influenza infection suggesting that platelets affect viral immune responses. 163 Many of these important associations are only beginning to be identified. More basic science study is needed to better define mechanistic roles for platelets in driving influenzarelated infection complications.…”