In Vivo Photodynamic Therapy With a Lipophilic Zinc(II) Phthalocyanine Inhibits Colorectal Cancer and Induces a Th1/CD8 Antitumor Immune Response

Abstract

T cells and higher levels of interferon-γ and tumor necrosis factor-α were also found in PDT-treated tumors. Conclusions: Pc9-T1107 PDT treatment reduced tumor growth, inducing an apoptotic cell death and activating an immune response. Lasers Surg. Med.

Zinc Complexes with Nitrogen Donor Ligands as Anticancer Agents

“…Anyway, notwithstanding the promising IC 50 and SI values, none of the complexes reported in Table 13 were validated in in vivo tests. In our survey, only 2 papers [ 101 , 218 ] report some in vivo data. In particular, complex 5a , showing high antitumor activity against HepG2 and SMMC-7721 cell lines and low toxicity in ICR mice, might represent a potential new approach for the treatment of hepatocellular carcinoma.…”

“…Besides, 42a -T1107 ( Figure 23 ) induced an apoptotic cell death both in two- and three-dimensional colon carcinoma cell cultures [ 217 ]. In addition, the in vivo effect of photodynamic therapy (PDT) with 42a -T1107 in a CT26 murine colon carcinoma model was explored [ 218 ]. 42a -T1107 inhibited tumor growth and prolonged mice survival, without signs of tissue-specific or systemic toxicity, inducing an apoptotic tumor cell death [ 218 ].…”

Photodynamic diagnosis and photodynamic therapy of colorectal cancer in vitro and in vivo

“…95 Pc9-T1107 delayed CRC tumor growth with apoptotic cell death being noted, due to a decrease in the expression levels of Bcl-XL, Bcl-2, procaspase 3, full length Bid and a signicant increase in active caspase-3 and the detection of PARP-1 cleavage, as well as high levels of interferon-g and tumor necrosis factor-a being found, in comparison to Pc9 delivery alone. 95 Similarly, within a study performed by Obaid et al (2015) zinc phthalocyanine (C11Pc) PS was bound to PEG gold nanoparticles and further functionalized with monoclonal antibodies specic for the human epidermal growth factor receptor-2 (HER-2). 96 Subcellular localization studies within HT-29 CRC cells noted selective bioconjugate absorption in acidic organelles, which is typical of enhanced receptor-mediated endocytosis.…”

Structurally diverse zinc(ii) complexes containing tripodal tetradentate phenoxido-amines with promising antiproliferative effects

“…73,74 These findings motivate deeper and intensive studies of zinc complexes in connection with their possible anticancer activities. 22,[41][42][43][44][45][46][47][48][49][50][51][52][53][54][55]64,[73][74][75][76][77][78] Interestingly, the number of tested Zn compounds as potential anticancer agents was dramatically increased over the last two decades (Fig. 1).…”