In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B
Davia Prischich,
Rosalba Sortino,
Alexandre Gomila-Juaneda
et al.
Abstract:Orexinergic neurons are critically involved in regulating arousal, wakefulness, and appetite. Their dysfunction has been associated with sleeping disorders, and non-peptide drugs are currently being developed to treat insomnia and narcolepsy. Yet, no light-regulated agents are available to reversibly control their activity. To meet this need, a photoswitchable peptide analogue of the endogenous neuroexcitatory peptide orexin-B was designed, synthesized, and tested in vitro and in vivo. This compound (photorexi… Show more
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