In Vivo Pharmacokinetics Assessment of Indocyanine Green-Loaded Nanoparticles in Tumor Tissue with a Dynamic Diffuse Fluorescence Tomography System

Zhang, Yanqi; Zhang, Limin; Yin, Guoyan; Ma, Wenjuan; Li, Jiao; Zhou, Zhongxing; Gao, Feng

doi:10.1007/s11307-019-01340-7

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…Although traditional photothermal agents such as ICG have a good single heating effect, they are overall poor in stability and sustained performance. [ 36,37 ] The photothermal stability affects the sustained photothermal effect, and the photothermal conversion effect of our laser on‐off system did not fluctuate much after being repeated three times, which indicated that our EOH system had good photothermal stability (Figure S3, Supporting Information). The above results showed that the EOH system had far‐reaching clinical application value.…”

Section: Resultsmentioning

confidence: 94%

A Light‐Responsive Injectable Hydrogel with Remodeling Tumor Microenvironment for Light‐Activated Chemodynamic Therapy

Liu

Chen

Huang

et al. 2022

Macromolecular Bioscience

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Chemodynamic therapy (CDT) based on Fenton-like reaction is often limited by the tumor microenvironment (TME), which has insufficient hydrogen peroxide, and single CDT treatment is often less efficacious. To overcome these limitations, a hydrogel-based system is designed to enhance the redox stress (EOH) by loading the composite nanomaterial Cu-Hemin-Au, into the agarose hydrogels. The hydrogels can reach the tumor site upon intratumoral injection, and then coagulate and stay for extended period. Once irradiated with near-infrared light, the Cu-Hemin-Au act as a photothermal agent to convert the light energy into heat, and the EOH gradually heated up and softened, releasing the Cu-Hemin-Au residing in it to achieve photothermal therapy (PTT). Benefiting from the glucose oxidase (GOx)-like activity of the Au nanoparticles, glucose in the tumor cells is largely consumed, and hydrogen peroxide (H 2 O 2 ) is generated in situ, and then Cu-Hemin-Au react with sufficient H 2 O 2 to generate a large amount of reactive oxygen species, which promote the complete inhibition of tumor growth in mice during the treatment cycle. The hydrogel system for the synergistic enhancement of oxidative stress achieves good PTT/CDT synergy, providing a novel inspiration for the next generation of hydrogels for application in antitumor therapy.

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Section: Resultsmentioning

confidence: 94%

A Light‐Responsive Injectable Hydrogel with Remodeling Tumor Microenvironment for Light‐Activated Chemodynamic Therapy

Liu

Chen

Huang

et al. 2022

Macromolecular Bioscience

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“…Consider a tomography problem in which the medium under test has a dynamic and its scattering potential changes from measurement to measurement. An example of such a system is dynamic Fluorescence Diffuse Optical Tomography (dynamic FDOT) which tomographically captures the distribution of fluorescent bio-markers, and has applications in determining the liver function, 1,2 tumor detection, 3 and drug assessment. To achieve a high spatial resolution we need to increase the number of sources and detectors which results in larger number of measurements in conventional tomography protocols, e.g.…”

Section: Introductionmentioning

confidence: 99%

Optimal tomography of dynamically evolving objects using machine learning algorithms

Javidan¹,

Esfandi²,

Pashaie³

2023

Optical Tomography and Spectroscopy of Tissue XV

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In this article we introduce a systematic approach for optimal scanning of dynamically evolving objects, including cases where the dynamics is unknown. The method is specifically designed to optimize each measurement and engineer illumination patterns with the goal of reducing the uncertainty left in our estimation of the sample. Concurrently, the algorithm uses system identification techniques to develop a mathematical model for the dynamics under test based on the acquired data and it uses the model to predict changes in the distribution and optimize upcoming measurements. The theory is developed and simulations are provided to better display discussed concepts.

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“…Generally, DFT systems can probe light by optical fibers combined with highly sensitive photoelectric sensors [photomultiplier tubes (PMT) or avalanche photodiodes], or alternatively by sensitive charge-coupled device (CCD) cameras. [13][14][15][16][17][18][19][20] Compared with CCD camera detection mode, fiber-based detection combining with high-sensitive photoelectric sensors and photoncounting technique allows higher detection sensitivity and larger dynamic measurement range, which is significantly beneficial to probing ICG suffering low quantum yield, especially after a period of metabolism in tissue. At present, the pharmacokinetics of ICG has been studied to assess tumor issues and mouse liver function with the support of fiber-based DFT systems.…”

Section: Introductionmentioning

confidence: 99%

“…Our group built a fiber-based DFT system with computed tomography (CT)-analogous scanning mode to study the metabolisms of ICG in healthy mouse liver as well as ICG-loaded nanoparticles in mouse tumor tissue. [18][19][20] Fiber-based DFT systems were commonly configured with 16 source and detection positions distributed around a circular holder at equal separations. When one source was illuminated, 16 detection data were collected on boundary simultaneously or sequentially by optical switching according to the detector number.…”

Section: Introductionmentioning

confidence: 99%

“…By rotating the object from 0 deg to 360 deg with an interval of 22.5 deg analogous to CT scan, the acquisition time for collecting one complete frame of the projection data (16 × 8) was ∼1.1 min under the consideration of the rotating object (2 s), photon counting (1 s), and optical switching time (0.02 s), which is equal to the measurement time of the system proposed by Liu et al, 13 and is longer than that proposed by Alacam et al 16 (8.8 s) without optical switch and with shorter photon-counting time (0.5 s). 19 In this work, to further improve the capability of dynamic measurement under the consideration of cost and efficiency, a unique designing scheme was proposed by adopting digital lock-in photon-counting technique for realizing simultaneous irradiation of multiple light sources and parallel detection of multiple detectors. To validate the effectiveness of the proposed system, a series of static and dynamic phantom experiments, as well as in vivo experiments were conducted.…”

Section: Introductionmentioning

confidence: 99%

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High-sensitivity dynamic diffuse fluorescence tomography system for fluorescence pharmacokinetics

et al. 2022

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Significance: Dynamic diffuse fluorescence tomography (DFT) can recover the static distribution of fluorophores and track dynamic temporal events related to physiological and disease progression. Dynamic imaging indocyanine green (ICG) approved by the food and drug administration is still under-exploited because of its characteristics of low quantum yield and relatively rapid tissue metabolism.Aim: In order to acquire the ICG tomographic image sequences for pharmacokinetic analysis, a dynamic DFT system was proposed.Approach: A fiber-based dynamic DFT system adopts square-wave modulation lock-in photoncounting scheme and series-parallel measurement mode, which possesses high sensitivity, large dynamic range, high anti-ambient light ability in common knowledge, as well as good cost performance. In order to investigate the effectiveness of the proposed system, the measurement stability and the anti-crosstalk-a crucial factor affecting the system parallelization-were assessed firstly, then a series of static phantoms, dynamic phantoms and in vivo mice experiments were conducted to verify the imaging capability. Results:The system has the limited dynamic range of 100 dB, the fluctuation of photon counting within 3%, and channel-to-channel crosstalk ratio better than 1.35. Under the condition of a sufficient signal-to-noise ratio, a complete measurement time for one frame image was 10.08 s. The experimental results of static phantoms with a single target and three targets showed that this system can accurately obtain the positions, sizes, and shapes of the targets and the reconstructed images exhibited a high quantitativeness. Further, the self-designed dynamic phantom experiments demonstrated the capability of the system to capture fast changing fluorescence signals. Finally, the in vivo experiments validated the practical capability of the system to effectively track the ICG metabolism in living mice.Conclusions: These results demonstrate that our proposed system can be utilized for assessing ICG pharmacokinetics, which may provide a valuable tool for tumor detection, drug assessment, and liver function evaluation.

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In Vivo Pharmacokinetics Assessment of Indocyanine Green-Loaded Nanoparticles in Tumor Tissue with a Dynamic Diffuse Fluorescence Tomography System

Cited by 9 publications

References 36 publications

A Light‐Responsive Injectable Hydrogel with Remodeling Tumor Microenvironment for Light‐Activated Chemodynamic Therapy

A Light‐Responsive Injectable Hydrogel with Remodeling Tumor Microenvironment for Light‐Activated Chemodynamic Therapy

Optimal tomography of dynamically evolving objects using machine learning algorithms

High-sensitivity dynamic diffuse fluorescence tomography system for fluorescence pharmacokinetics

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